|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells显示文摘 | ANGELO D M GIUSEPPE F KATIA A | 2006 | Journal of Nutritional Biochemistry2006，17，： | 1 |
| 2 | Effect of graphite crystal structure on lithium electrochemical intercalation 显示文摘 | KATIA G ANNIE F B SERGE F | 1999 | J Electrochemical Society1999，146，10： | 1 |
| 3 | Addition of the microchromosome GGA25 to the chicken genome sequence assembly through radiation hybrid and genetic mapping 显示文摘 | MARINE D KATIA F MARIE G | 2008 | BMC Genomics2008，9，： | 1 |
| 4 | Effect of graphite crystal structure on lithium electrochemical intercalation显示文摘 | Katia G Annie F B Serge F | 1999 | Journal of the Electrochemical Society1999，146，10： | 1 |
| 5 | Analysirtof the deterministic unsteady flow in a low-speed axialfan with inlet guide vanes 显示文摘 | Jesus M F 0 Katia MAD Carlos S M | 2008 | Journal of Fluids Kngi-neering2008，130，3： | 1 |
| 6 | Presence of necrotic strains of Potato virus Y in Mexican potatoes显示文摘 | Victoriano R R Katia A Gustavo F | 2009 | Virology Journal2009，6，： | 1 |
| 7 | Effect of graphite crystal structure on lithium electrochemical intercalation 显示文摘 | ANNIE F B SERGE F | 1999 | J Electrochem Soc1999，146，10： | 1 |
| 8 | Involvement of mitogen-activated protein kinases in Group B Streptococcus-induced macrophage apoptosis 显示文摘 | Katia F Ilaria F Andrea B | 2003 | Pharmacological Research2003，47，4： | 1 |
| 9 | OWLS-MX: A hyb,'id semantic web service matchmaker for OWI,-S services显示文摘 | MATFHIAS K BENEDIKT F KATIA S | 2009 | Web Semantics: Science Services and A- gents on the World Wide Web2009，7，2： | 1 |
| 10 | Epigenetic regulation of mammalian genomic imprinting显示文摘 | Katia D Robert F | 2004 | Cur Opinion in Genet & Dev2004，14，： | 1 |
| 11 | Association Between the CfxA Gene and Transposon Tn4555 in Bacteroides distasonis Strains and Other Bacteroides Species显示文摘 | LIVIAQ F KATIA E S A JESSICA M B D | 2007 | Current microbiology vol2007，54，： | 1 |
| 12 | The efficacy of drags for the treatment of LUTS/BPH,A study in 6 european countries 显示文摘 | ANNIE H RICHARD F KATIA V | 2006 | Eur Urol2006，49，6： | 1 |
| 13 | Poly (Vinylaleo- hol)-based Film Potentially Suitable for Antimierobial Pack- aging Applications显示文摘 | ALESSANDRO M KATIA P PAOLA F | 2014 | Journal of Food Science2014，79，4： | 1 |
| 14 | Epigenetic regulation of mammalian genomic imprinting显示文摘 | Katia D Robert F | 2004 | Current Opinion Gene Dev2004，14，2： | 1 |
| 15 | Drug-induced hepatic injury in children: a case/non-case study of suspected adverse drug reactions in VigiBase显示文摘 | CARMEN F ANNALlSA C KATIA M C | 2010 | Br J Clin Pharmacol2010，70，5： | 1 |
| 16 | Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease显示文摘BACKGROUND 1,3-beta-D-glucan(BG)is a ubiquitous cell wall component of gut microorganisms.We hypothesized that the serum levels of BG could reflect active intestinal inflammation in patients with inflammatory bowel disease.AIM To determine whether the serum BG concentrations correlate with intestinal inflammation.METHODS A prospective observational study was performed in a tertiary referral center,from 2016 to 2019,in which serum BG was determined in 115 patients with Crohn’s disease(CD),51 with ulcerative colitis(UC),and 82 controls using a photometric detection kit.Inflammatory activity was determined by ileocolonoscopy,histopathology,magnetic resonance enterography,and biomarkers,including fecal calprotectin(FC),C-reactive protein,and a panel of cytokines.The ability of BG to detect active vs inactive disease was assessed using the area under the receiver operating characteristic curve.In subgroup analysis,serial BG was used to assess the response to therapeutic interventions.RESULTS The serum BG levels were higher in CD patients than in controls(P=0.0001).The BG levels paralleled the endoscopic activity in CD patients and histologic activity and combined endoscopic and histologic activity in both CD and UC patients.The area under the curve(AUC)in receiver operating characteristic analysis to predict endoscopic activity was 0.694[95%confidence interval(CI):0.60-0.79;P=0.001]in CD,and 0.662(95%CI:0.51-0.81;P=0.066)in UC patients.The AUC in receiver operating characteristic analysis to predict histologic activity was 0.860(95%CI:0.77-0.95;P<0.001)in CD,and 0.786(95%CI:0.57-0.99;P=0.015)in UC patients.The cut-off values of BG for both endoscopic and histologic activity were 60μg/mL in CD,and 40μg/mL in UC patients.Performance analysis showed that the results based on BG of 40 and 60μg/mL were more specific for predicting endoscopic activity(71.8%and 87.2%for CD;and 87.5%and 87.5%for UC,respectively)than FC(53.3%and 66.7%for CD;and 20%and 80%for UC,respectively);and also histologic activity(60.5%and 76.3%for CD;and 90.0%and 95.0%for UC,respectively)than FC(41.7%and 50.0%for CD;and 25%and 50%for UC,respectively).Regarding the clinical,endoscopic,and histologic activities,the BG levels were reduced following therapeutic intervention in patients with CD(P<0.0001)and UC(P=0.003).Compared with endoscopic(AUC:0.693;P=0.002)and histologic(AUC:0.868;P<0.001)activity,no significant correlation was found between serum BG and transmural healing based on magnetic resonance enterography(AUC:0.576;P=0.192).Positive correlations were detected between BG and IL-17 in the CD(r:0.737;P=0.001)and the UC group(r:0.574;P=0.005),and between BG and interferon-gamma in the CD group(r:0.597;P=0.015).CONCLUSION Serum BG may represent an important novel noninvasive approach for detecting mucosal inflammation and therapeutically monitoring inflammatory bowel diseases,particularly in CD. | Katia Farias e Silva Hayandra F Nanini Cynthia Machado Cascabulho Siane L B Rosas Patricia T Santana Antonio Joséde V Carneiro Elias Anaissie Marcio Nucci Heitor Siffert Pereira de Souza | 2021 | World Journal of Gastroenterology2021，27，9： | 1 |
| 17 | Cold-set whey protein-flaxseed gum gels induced by mono or divalent salt addition显示文摘 | Katia R K Angelo L F C Rosiane L C | 2011 | Food Hydrocolloids2011，25，5： | 1 |
| 18 | 前列腺癌MDM2的异常表达显示文摘在局限性前列腺癌中p53突变很少见,癌蛋白MDM2(其基因有一个p53应答元件)可以促进p53降解并抑制p53激活以及细胞周期停滞与凋亡有关基因的转录,形成一个负反馈调控。我们对118例根治性切除的局限性前列腺癌病例。用免疫组织化学检测p53和MDM2的表达,并用聚合酶链反应-单链构象多态性检测p53外显子5至8的突变情况,对其中28例,用Ki-67抗体免疫组织化学方法检测细胞增生情况,用脱氧核苷酸转移酶介导的生物素dUTP末端标记法检测凋亡。尽管未发现p53突变,我们在31.4%病例中检出p53蛋白,这些病例的Gleason评分较高(P=0.03),且属于较晚期的肿瘤阶段(P=0.02),MDM2在40.7%的病例中超量表达,这些病例的肿瘤体积较大(P=0.001),p53和MDM2均阳性的肿瘤体积较大(P=0.003),且处于较晚期阶段(P=0.03),在上述28例中,MDM2阳性肿瘤的增生指数较高(P=0.046),而p53阳性肿瘤的凋亡指数较高(P=0.01),我们得出结论:尽管p53突变在前列腺癌发生中少见,而通过免疫组织化学方法常可检测到p53蛋白阳性,并与凋亡减少及肿瘤分期分级增高相关。我们还得出结论,MDM2超量表达在前列腺癌发生中具有作用,它常被检出并与肿瘤增生及肿瘤体积的增长有关,最后,我们推测MDM2阳性/p53阳性表型标志前列腺癌具有侵袭性行为。 | Katia R M Leite Marcello F Franco 等 | 2001 | 世界医学杂志2001，5，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员