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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 3 | Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma显示文摘AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related 'epigenetic clock' genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture sequencing.RESULTS Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P < 0.05, ?β≥ 10%). In the adenoma vs normal comparison, 70 CpG sites differed significantly, including hypermethylated DKK3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased SFRP1 m RNA levels in children compared to normal adult samples(P < 0.05). In CRC tissue the mR NA expression of 117 agerelated genes were changed, while in adenoma samples 102 genes showed differential expression compared with normal colonic tissue(P < 0.05, logF C > 0.5). The change of expression for several genes including SYNE1, CLEC3 B, LTBP3 and SFRP1, followed the same pattern in aging and carcinogenesis, though not for all genes(e.g., MGP). CONCLUSION Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the m RNA expression of certain CRC- and adenoma-related key control genes. | Orsolya Galamb Alexandra Kalmár Barbara Kinga Barták árpád V Patai Katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 4 | Prediction of Dynamic and Aerodynamic Characteristics of the Centrifugal Fan with Forward Curved Blades显示文摘The main aim of this paper is determine the centrifugal fan with forward curved blades aerodynamic characteristics based on numerical modeling. Three variants of geometry were investigated. The first, basic 'A' variant contains 12 blades. The geometry of second 'B' variant contains 12 blades and 12 semi-blades with optimal length[1]. The third, control variant 'C' contains 24 blades without semi-blades. Numerical calculations were performed by CFD Ansys. Another aim of this paper is to compare results of the numerical simulation with results of approximate numerical procedure. Applied approximate numerical procedure [2] is designated to determine characteristics of the turbulent flow in the bladed space of a centrifugal-flow fan impeller. This numerical method is an extension of the hydro-dynamical cascade theory for incompressible and inviscid fluid flow. Paper also partially compares results from the numerical simulation and results from the experimental investigation. Acoustic phenomena observed during experiment, during numerical simulation manifested as deterioration of the calculation stability, residuals oscillation and thus also as a flow field oscillation. Pressure pulsations are evaluated by using frequency analysis for each variant and working condition. | Jií Polansky László Kalmár Roman Gápár | 2013 | Journal of Thermal Science2013，22，6： | 2 |
| 5 | Nutritional and life-quality consequences of aboral pouch construction after total gastrectomy:a randomized,controlled study显示文摘 | Horváth OP Kalmár K Cseke L | 2001 | Eur J Surg Oncol2001，27，6： | 1 |
| 6 | Metastatic prostate cancercomplicated with chronic disseminated intravascular coagulopa-thy causing acute renal failure,mimicking thrombotic thrombo-cytopenic purpura and hemolytic uremic syndrome:pathomech-anism,differential diagnosis and therapy related to a case显示文摘 | Deme D Ragán M Kalmár K | 2010 | Magy Onkol2010，54，4： | 1 |
| 7 | A simple and efficient method for PCR amplication DNA extraction from ancient bones显示文摘 | Kalmár T Bachati C Z Marcsik A | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 8 | Clinical pathways:experiences,expectations,and perspectives显示文摘 | Lohfert C Kalmár P | 2006 | Intemist (Berl)2006，47，67： | 1 |
| 9 | Causes of iusulin resistance 显示文摘 | Kalm C R | 1995 | Nature1995，373，： | 1 |
| 10 | Clinical pathways:experiences,expectations,and perspectives显示文摘 | Lohfert C Kalmár P | 2006 | Der Internist2006，47，67： | 1 |
| 11 | Personal use of hair dyes and risk of bladder cancer: A meta-analysis of epidemiologic data显示文摘 | Kelsh M A Alexander D D Kalmes R M | 2008 | Cancer Causes Control2008，19，6： | 1 |
| 12 | Nutritional and life-quality consequences of aboral pouch construction after total gastrectomy: a randomized, controlled study显示文摘 | Horv 6 th OP Kalm 6 r K Cseke L | 2001 | Eur J Surg Oncol2001，27，6： | 1 |
| 13 | The value of screening for retinopathy and microalbuminuria in patients with type 2 diabetes in primary health care显示文摘 | kalm H Blohme G | 1993 | Scand J Prim Health Care1993，11，2： | 1 |
| 14 | The values of screening for reti- nopatby and microalbuminuria in patients with type II diabetes in primary health care显示文摘 | Eggertsen R Kalm H Blohme G | 1993 | Scan J Prim Health Care1993，11，2： | 1 |
| 15 | Postprandial gastrointestinal hormone production is different, depending on the type of construction following total gastrectomy显示文摘 | Kalm 6 r K N 6 meth J Kelemen D etal | 2006 | Ann Surg2006，243，4： | 1 |
| 16 | 4'-OH-JH-Ⅲ: an additional hydroxylated juvenile hormoneproduced by locust corpora allata in vitro显示文摘 | BERNARD MAUCHAMP ERIC DABROUZET KALMES R | 1999 | Insect Biochemistry and Molecular Biology1999，29，： | 1 |
| 17 | Personal use of hair dyes and risk of bladder cancer: A meta-analysis of epidemiologic data 显示文摘 | Kelsh M A Alexander D D Kalmes R M | 2008 | Cancer Cauls and Control2008，19，6： | 1 |
| 18 | A simple and efficient method for PCR amplifiable DNA extraction from ancient bones显示文摘 | KALMáR T BACHRATI C Z MARCSIKA | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 19 | Estradiol increases the production of sex hormone-binding globulin but not insulin-like growth factor binding protein-1 in cultured human hepatoma cells 显示文摘 | Kalme T Loukovaara M Koistinen R | 1999 | Fertil Steril1999，72，2： | 1 |
| 20 | Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor显示文摘 | Kalmes A Vesti B R Daum G | 2000 | Circ Res2000，87，： | 1 |
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