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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Isolation and diagnosis of Helicobacter pylori by a new method: Microcapillary culture显示文摘AIM:To investigate the performance of the microcapillary culture method(MCM) in Helicobacter pylori(H.pylori) isolation and diagnosis.METHODS:Microcapillary culture(MC),classical culture(CC),rapid urease(CLO) test,and histopathologic examination(HE) were performed with biopsy samples.Homogenized biopsy samples were loaded into capillary tubes and incubated for 48 h at 37 ℃ without providing a microaerophilic environment.Additionally,three or four loops of the homogenized sample were inoculated in a ready-to-use selective medium(Becton Dickinson,Helicobacter Agar,Modified) specific for the isolation of H.pylori and incubated at 37 ℃ in a microaerophilic atmosphere provided by Campy Gen(Becton Dickinson,Gas Pack).Bacteria reproducing in microcapillary tubes were evaluated in an inverted microscope and also were evaluated after performing a CC with the content.Results obtained by CC,CLO test,and HE were compared with those of MC.The diagnostic performances of the methods used in this study were evaluated for specificity,sensitivity,positive predictive value(PPV),negative predictive value(NPV),and CI.RESULTS:H.pylori was found positive by CLO test +HE and/or CC culture in 26 patient antrum and corpus biopsy samples.In 25(25/26) patient biopsy samples,H.pylori was isolated by MCM,whereas in only 14(14/26) patient biopsy samples,H.pylori was isolatedby CC.CLO test and HE were found positive in 17(17/26) patient biopsy samples.Comparing the results of the isolation of H.pylori by MCM,CC,CLO test,and HE,the sensitivity of the MCM was found as 96%,the specificity as 80%,the PPV as 83%,the NPV as 95%,and the 95%CI as 0.76(χ2 =31.51,P < 0.01) whereas the sensitivity of the CC was found as 54%(χ2 =19.15,P < 0.01),and the sensitivity of the CLO test and HE were found as 65%(χ2 =25.26,P < 0.01).CONCLUSION:This new microcapillary cultivation method for H.pylori has high diagnostic sensitivity compared with CC,HE,and CLO tests. | Adil M Allahverdiyev Melahat Bagirova Reyhan Caliskan Hrisi Bahar Tokman Hayat Aliyeva Gokce Unal Olga Nehir Oztel Emrah Sefik Abamor Hilal Toptas Pelin Yuksel Fatma Kalayci Mustafa Aslan Yusuf Erzin Kadir Bal Bekir S Kocazeybek | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 3 | Neurochemical metabolites in the medial prefrontal cortex in bipolar disorder A proton magnetic resonance spectroscopy study显示文摘The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type Ⅰ and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity. | Osman zdel Demet Kalayci Gülfizar Szeri-Varma Yilmaz Kiroglu Selim Tümkaya Tuge Toker-Ugurlu | 2012 | Neural Regeneration Research2012，7，36： | 2 |
| 4 | Trend analysis of streamflow in Turkey显示文摘 | Kahya E Kalayci S | 2004 | J Hydrol2004，289，： | 1 |
| 5 | Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats显示文摘 | Gul S Celik SE Kalayci M | 2005 | Surg Neurol2005，64，4： | 1 |
| 6 | Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology显示文摘 | Aydin S Kobat MA Kalayci M | 2014 | Peptides2014，56，： | 1 |
| 7 | Giant malignantgastrointestinal stromal tumor presenting as anintraabdomi-hal abscess显示文摘 | Altaca G Demiralay E Kalayci S A | 2009 | J Gastrointestin Liver Dis2009，18，4： | 1 |
| 8 | Trend analysis of streamflow in Turkey 显示文摘 | Kahya E Kalayci S | 2004 | Journal of Hydrology2004，289，： | 1 |
| 9 | Construction tolerances and design parameters for NSM FRP reinforcement in concrete beams 显示文摘 | Kalayci A S Yalim B Mirmiran | 2010 | Construction and Building Materials2010，24，10： | 1 |
| 10 | Effect of coenzyme Q10 on ischemia and neuronal damage in an experimental traumatic brain-injury model in rats显示文摘 | Kalayci M Unal MM Gul S | 2011 | BMC Neurosci2011，12，： | 1 |
| 11 | Trend Analysis of Streamflow inTurkey显示文摘 | KAHYA E KALAYCI S | 2004 | Journal of Hydrology2004，289，1： | 1 |
| 12 | Decreased saliva/serum irisin concentrations in the acute myocardial infarction premising for being a new candidate biomarker for diagnosis of this patholo- gy显示文摘 | Aydin S Kobat MA Kalayci M | 2014 | Peptides2014，56，： | 1 |
| 13 | A comparison of the in vitro cytotoxicity of two root canal sealers显示文摘 | Oztan MD Yilmaz S Kalayci A | | 0，，04： | 1 |
| 14 | Trend Analysis of Stream Flow inTurkey显示文摘 | KAHYA E KALAYCI S | 2004 | Journal of Hydrology2004，289，12： | 1 |
| 15 | Equilibrium, kinetics and thermodynamic studies on the adsorption of phenol onto chitin 显示文摘 | DURSUN A Y KALAYCI C S | 2005 | Journal of Hazardous Materials B2005，123，123： | 1 |
| 16 | Evaluation of apical sealing ability and adap- tation to dentine of two resin- based sealers显示文摘 | Sevimay S Kalayci A | 2005 | J Oral Rehabil2005，32，2： | 1 |
| 17 | Distraction osteogenesis of basal mandibular bone for reconstruction of the alveolar ridge显示文摘 | Uckan S Dolanmaz D Kalayci A | 2002 | Br J Oral Maxillofac Surg2002，40，5： | 1 |
| 18 | A rare complication of spinal surger- y : cerebellar hemorrhage 显示文摘 | Gul S Kalayci M Acikgoz B | 2010 | Turk Neurosurg2010，20，3： | 1 |
| 19 | A rare complication of spinal surgery:cere-bellar hemorrhage显示文摘 | Gul S Kalayci M Acikgoz B | 2010 | Turk Neurosurg2010，20，3： | 1 |
| 20 | A tabu search algorithm for balan- cing a sequence-dependent disassembly line显示文摘 | Kalayci C B Gupta S M | 2014 | Production Planning & Control2014，25，2： | 1 |
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