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| 1 | DOG1是一种敏感和特异性的胃肠道间质瘤的标记物显示文摘 | Espinosa I Lee C H Kim M K 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 117 |
| 2 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 3 | 具有极性反转的乳头状肾肿瘤:形态学、免疫组化和分子学研究显示文摘作者评估了特殊类型乳头状肾肿瘤的临床病理和染色体特征,并将其与1型和2型乳头状肾细胞癌进行比较。18例中,9例男性,9例女性;年龄范围46~80岁(平均64岁,中位年龄66岁);肿瘤直径0.6~3 cm(平均1.63 cm,中位直径1.4 cm);其中14例WHO/ISUP 2级,4例WHO/ISUP 1级,肿瘤分期均为pT1期。这类肿瘤具有细小纤维血管轴心的分支状乳头,被覆立方/柱状细胞,胞质颗粒状嗜酸性,管腔边缘光滑,核规则且多位于细胞顶端,偶尔核仁明显或不明显。5例形成小管状结构,9例有明显的胞质空泡,10例具有假包膜。18例肿瘤均无砂粒体、坏死、核分裂象和细胞内含铁血黄素沉积。相比之下,1型乳头状肾细胞癌具有纤细的乳头状结构,被覆单层细胞,胞质稀少,细胞核通常位于乳头状结构基底部呈单层排列,而2型乳头状肾细胞癌具有较宽的乳头状结构,表面被覆细胞呈假复层排列,胞质嗜酸性,核无规则分布。1型和2型乳头状肾细胞癌可见砂粒体、泡沫样巨噬细胞以及细胞内含铁血黄素沉积。免疫组化结果显示,18例肿瘤中CK(AE1/AE3)、EMA、MUC1、CD10、GATA3和L1CAM均阳性。 | 魏建国(摘译) 方三高(审校) Al-Obaidy K I Eble J N Cheng L | 2019 | 临床与实验病理学杂志2019，35，8： | 15 |
| 4 | 药物不良反应:定义、诊断与管理显示文摘我们将药物不良反应定义为'药物用于防治疾病而引起可以觉察到的有害的或不利的反应,这预示着继续给药会有危险,需要预防或特定治疗措施,或减少剂量,乃至停药',这样一些反应现今以世界卫生组织不良反应术语(WHO-ART)进行报告,后者终将成为国际疾病分类(ICD)的一个组成部分. | I Ralph Edwards Jeffrey K Aronson | 2001 | 药物不良反应杂志2001，3，2： | 14 |
| 5 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 6 | 基因表达分析表明p63是骨巨细胞瘤的一种诊断用标记显示文摘 | Lee C H Espinosa I Jensen K C 饶秋(摘译) | 2008 | 临床与实验病理学杂志2008，24，4： | 13 |
| 7 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 8 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘 | M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz | 2006 | Cytotherapy2006，，4： | 11 |
| 9 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 10 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，6： | 11 |
| 11 | 玉米种子大小和播深对出苗和幼苗活力的影响显示文摘林波波河省小农户主要以玉米为主粮来生产,播种时常因翻耕翻埋种子而造成植株个体生长差。本研究目的就是要确定种子大小和播种深度对玉米出苗和生长的影响。实验处理包括两种不同大小的种子(大粒种子和小粒种子)和4个播种深度(5cm、10cm、15cm、20cm)。种子大小对出苗率无显著影响,但不同播深对出苗率有显著影响。种子大小和播种深度均对幼苗高度有显著影响。种子大小对幼苗干重和叶片数没有影响。随播种深度增加,幼苗干重减少。结果显示,播深在5cm和10cm时,种子大小对出苗和幼苗活力没有影响,但播种深度在15cm和20cm时,对出苗和种子活力有不良影响。 | Molatudi R L Mariga I K 马志强 | 2010 | 中国种业2010，，7： | 11 |
| 12 | Stereotactic body radiation therapy for non-small cell lung cancer:A review显示文摘Stereotactic body radiation therapy(SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC. Patient eligibility,prescription dose and delivery, and follow up duration varied widely. Threeyears overall survival ranged from 43% to 95% with loco-regional control of up to 98% at 3 years. Up to 33% of patients failed distantly after SBRT at 3 years. SBRT was generally well tolerated with 10%-30% grade 3-4 toxicities and a few treatment-related deaths. No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT, central and peripheral lung tumors, or inoperable and operable patients. SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC. SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery. Decreasing fractionation schedules have been consistently shown to be both safe and effective. Distant failure is common, and chemotherapy may be considered for select patients. However, the survival benefit of additional interventions, such as chemotherapy, for early stage NSCLC treated with SBRT remains unclear. | Kavitha M Prezzano Sung Jun Ma Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 10 |
| 13 | NKX3-1是诊断EWSR1-NFATC2肉瘤和间叶性软骨肉瘤有用的免疫组化标志物显示文摘目前,NKX3-1被普遍认为是前列腺腺癌的高度敏感和特异性标志物。NKX3-1转录组数据提示其mRNA在EWSR1-NFATC2肉瘤中表达上调,为此作者探讨NKX3-1免疫组化在肉瘤诊断中的应用。作者采用免疫组化检测11例EWSR1-NFATC2肉瘤和168例组织学形态相似肿瘤的全组织切片中NKX3-1的表达。11例EWSR1-NFATC2肉瘤均由小圆形或卵圆形细胞构成,除1例外其余至少局部表现为纤维化或黏液样背景下呈典型的巢状、条索状或小梁状生长模式。 | Yoshida K Machado I Motoi T 王婷(摘译) 余英豪(审校) | 2020 | 临床与实验病理学杂志2020，36，11： | 9 |
| 14 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘 | M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz | 2006 | Cytotherapy2006，，4： | 9 |
| 15 | Cranial base chordoma——long term outcome and review of the literature显示文摘BACKGROUND: The purpose of this study is to clarify the latest long-term therapeutic result for cranial base chordomas.We are seeking an improvement of long term therapeutic outcome through a review of cranial base chordomas treated in | Yoneoka Y Tsumanuma I Fukuda M Tamura T Morii K Tanaka R Fujii Y | 2008 | 中国神经肿瘤杂志2008，6，3： | 9 |
| 16 | Primary biliary cirrhosis in HBV and HCV patients:Clinical characteristics and outcome显示文摘AIM: To present the characteristics, management and outcome of patients with hepatitis B virus(HBV) or hepatitis C virus(HCV) infections concurrent with primary biliary cirrhosis(PBC).METHODS: Since January 2001 to September 2009,we retrospectively evaluated the medical records of all HBV(n = 1493) and HCV patients(n = 526) who are followed in our center for the presence of concurrent PBC. Seventeen patients identified with concurrent viral hepatitis and PBC(8 HCV and PBC; follow-up: 61 ± 37 mo and 9 HBV and PBC; follow-up: 57 ± 38 mo). PBC diagnosis was established if the patients met at least two of the following criteria: positivity for antimitochondrial antibody, elevated cholestatic enzymes and histological lesions of PBC.RESULTS: HCV or HBV diagnosis preceded that of PBC in most patients by many years. PBC diagnosis was based on the presence of antimitochondrial antibody and elevated cholestatic enzymes in all 17 patients,while one third(5/17; 29.4%) experienced severe pruritus many years before diagnosis. Patients with PBC and HBV were significantly younger at diagnosis of PBC compared to patients with PBC and HCV(56.1 ± 11.2vs 68.5 ± 10.3, respectively, P < 0.05). At initial clinical and histological assessment the majority of patients were cirrhotics(10/17; 58.8%) with the group of PBC and HCV carrying the highest frequency(87.5% vs33.3% in PBC and HBV; P < 0.05). The patients with HBV and concomitant PBC seem to have better outcome compared to those with HCV and PBC since none of the 6 non-cirrhotics with HBV and PBC developed cirrhosis during follow-up.CONCLUSION: PBC diagnosis in HBV or HCV patients is very difficult and usually delayed. Therefore, in any case, cholestasis should alert physicians to further search for PBC. | Eirini I Rigopoulou Kalliopi Zachou Nikolaos K Gatselis Georgia Papadamou George K Koukoulis George N Dalekos | 2013 | World Journal of Hepatology2013，5，10： | 7 |
| 17 | 温度对甜菜种子萌发速率和线粒体活性的影响(英文)显示文摘研究了不同温度对甜菜种子萌发速率和线粒体活性的影响。在 7,14和 2 0℃中甜菜种子萌发 5 0 %需要的时间分别是 7,3和 2 3d ;萌发 5 0 %的热时间大约是 46℃·d。在 7,14和 2 0℃萌发的种子和幼苗的线粒体中 ,总蛋白含量以及细胞色素氧化酶 (CCO)和苹果酸脱氢酶 (MDH)的活性随着萌发进程增加 ;相对分子质量大约为 1880 0 ,35 0 0 0和 36 0 0 0的蛋白质随着萌发进程降低 ;相对分子质量大约为 2 2 0 0 0的蛋白质在 7℃中逐渐增加 ,在 14和 2 0℃中则先少量增加然后下降。 2 0℃中萌发的种子和幼苗的线粒体的CCO和MDH的比活性和总活性比在 7和 14℃中高。这些结果表明 ,萌发温度显著地影响种子的萌发速率、线粒体的CCO和MDH活性以及较小相对分子质量热休克蛋白 2 | 宋松泉 FREDLUND K M MΦLLER I M | 2002 | 中山大学学报(自然科学版)2002，41，1： | 7 |
| 18 | Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers显示文摘AIM: To elucidate the differences in somatic, psycho-logical and biochemical pattern between the subtypes of irritable bowel syndrome (IBS). METHODS: Eighty IBS patients, 30 diarrhoea pre-dominant (D-IBS), 16 constipation predominant (C-IBS) and 34 alternating IBS (A-IBS) underwent physi-otherapeutic examinations for dysfunctions in body movements and awareness and were compared to an apparently healthy control group (AHC). All groups an-swered questionnaires for gastrointestinal and psycho-logical symptoms. Biochemical variables were analysed in blood. RESULTS: The D-IBS group showed less body aware-ness, less psychological symptoms, a more normal sense of coherence and psychosocial rating as well as higher C-peptide values. C-IBS had a higher degree of body dysfunction and psychological symptoms, as well as the lowest sense of coherence compared to controls and D-IBS. They also demonstrated the most elevated prolactin levels. A-IBS had the lowest degree of body disturbance, deteriorated quality of life and affected bi-ochemical pattern. All subtypes had higher pain scores compared to controls. In addition they all had signifi -cantly increased triglycerides and elevated morning cortisol levels, however, without statistical signifi cance compared with the controls.CONCLUSION: IBS subtypes showed different pro-files in body awareness, somatic and psychological symptoms and in biochemical variables. D-IBS differed compared to the other groups by lowered body aware-ness, less psychological symptoms and a higher sense of coherence and elevated C-peptide values. C-IBS and A-IBS subtypes suffered more from depression and anxiety, associated with a lower quality of life. These differences may be important and will be taken into account in our treatment of these patients. | Elsa M Eriksson Kristina I Andrén Henry T Eriksson Gran K Kurlberg | 2008 | World Journal of Gastroenterology2008，14，31： | 7 |
| 19 | 液态二氧化碳对俄罗斯某油藏稠油的膨胀与萃取作用实验显示文摘利用俄罗斯某油藏稠油样品,通过实验分析稠油与液态CO_2混合后两者之间的质量传递作用以及混合物中重相(稠油和CO_2的混合物)和轻相(纯CO_2)的特性变化。研究表明,当混合物中CO_2浓度为10%时,稠油基本上不发生膨胀;当混合物中CO_2浓度高于26%时,由于稠油轻质组分的萃取量超过了CO_2在稠油中的饱和量导致重相体积减少,重相黏度呈指数增长,混合物中CO_2的浓度为26%时,有效降低重相黏度的作用最强;重相和轻相密度、体积系数、气体溶解度和闪蒸重相黏度均随着混合物中CO_2浓度的增加而变大;混合物中最佳的CO_2浓度是26%,此时稠油膨胀最大、重相的黏度值最小;混合物中CO_2的浓度为10%~26%时,轻相的体积最小,驱油效果最好。 | LOBANOV A A SHHEKOLDIN K A STRUCHKOV I A ZVONKOV M A HLAN M V PUSTOVA E J KOVALENKO V A ZOLOTUKHIN A B | 2018 | 石油勘探与开发2018，45，5： | 6 |
| 20 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
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