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| 1 | The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8显示文摘 | Sophie Clément Stéphanie Pascarella Stéphanie Conzelmann Carmen Gonelle-Gispert Kévin Guilloux Francesco Negro | 2010 | Journal of Hepatology2010，，5： | 1 |
| 2 | The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8显示文摘 | Sophie Clément Stéphanie Pascarella Stéphanie Conzelmann Carmen Gonelle-Gispert Kévin Guilloux Francesco Negro | 2010 | Journal of Hepatology2010，，5： | 2 |
| 3 | Intraspecific maternal competition in insect parasitoids induces summer diapause in insect parasitoids显示文摘Organisms often live in unpredictable environments and have to adopt life history strategies that optimize their fitness under these conditions.According to bet-hedging theory,individuals can reduce variation in fitness outcomes by investing in different strategies at the same time.For arthropods,facultative summer diapause enables survival during dry and hot periods of the year,and can be triggered by a decrease in resource abundance. However,the effect of resource depletion on diapause induction has never been disentangled from the effect of the perception of the presence of competitors.Using two solitary parasitoid species of cereal aphids as a model system,Aphidius avenae (Haliday)and Aphidius rhopalosiphi (De Stefani-Perez)(Hymenoptera:Braconidae),we tested whether (i)low absolute host density and/or (ii)high levels of parasitoid females'competition lead to maternal-induced summer diapause in parasitoid offspring.Under summer-like climatic conditions,emerging parasitoid females were (i)reared alone and exposed to different host densities (from 5 to 130 aphids),or (ii)reared together with competing females (from 2 to 20 females)and then exposed individually to 50 aphids.For both parasitoid species, low aphid densities did not induce summer diapause.However,the incidence of summer diapause increased up to a maximum of 11% with increasing levels of competition expe rienced by female parasitoids.More than 60% of the females produced both diapausing and nondiapausing offspring after being kept at the two highest competition densities. Such a 'spreading-the-risk'strategy has likely evolved to optimize parasitoid fitness by preventing the following generation from exposure to low populations of suitable hosts and high mortality from superparasitism.These results provide the first experimental evidence of direct maternal competition-induced diapause in insects,and may change the way we apprehend the evolution of arthropod seasonal ecology,by considering intraspecific competition. | Kévin Tougeron George Hraoui Cécile Le Lann Joan van Baaren Jacques Brodeur | 2018 | Insect Science2018，25，6： | 0 |
| 4 | sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3]. | Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive | 2021 | Cellular & Molecular Immunology2021，18，8： | 8 |
| 5 | Positive effect of spring advance on the diet quality of an alpine herbivore显示文摘Changes in vegetation phenology related to global warming are having alarming effects on the life history traits of many herbivore species.Such changes are particularly critical in alpine ecosystems,where strong climate limitations on plant growth make seasonal synchronization imperative for the growth,reproduction and survival of herbivores.However,despite the pivotal role of resource-use strategies on the performances of such species,few studies have explicitly assessed the mechanistic impact of climate change on their diets.We aimed to fill this gap by studying the effect of spring onset on the dietary composition and quality of a medium-size alpine herbivore while considering density-dependent processes and age-and sex-specific differences in foraging behavior.Using an exceptional,long-term(24 years)direct individual-based dietary monitoring of a Pyrenean chamois population(Rupicapra pyrenaica pyrenaica),we showed that ongoing earlier onsets of spring are leading to an earlier access to high-quality forage and therefore a higher diet quality at a fixed date,without apparent changes in diet composition.We also showed that at high densities,intraspecific competition reduced diet quality by driving animals to feed more on woody plants and less on nutritious forbs and graminoids.By assessing the mechanistic effects of global warming on the dietary patterns of species at the center of trophic networks,this study is an essential step for predictive models aiming at understanding the ongoing ecosystem consequences of the global climatic crisis. | Johan ESPUNYES Emmanuel SERRANO Sara CHAVES Jordi BARTOLOMÉ Pierre MENAUT Elena ALBANELL Pascal MARCHAND Kévin FOULCHÉ Mathieu GAREL | 2022 | Integrative Zoology2022，17，1： | 1 |
| 6 | Targeting liver X receptors in human health: deadlock or promising trail?显示文摘 | Emilie Viennois Auré lien JC Pommier Ké vin Mouzat Abdelkader Oumeddour Fatim-Zohra El Hajjaji Julie Dufour Fran? oise Caira David H Volle Silvè re Baron Jean-Marc A Lobaccaro | 2011 | Expert Opinion on Therapeutic Targets2011，，2： | 1 |
| 7 | Spatial distribution and impacts of climate change on Milicia excelsa in Benin,West Africa显示文摘African teak(Milicia excelsa(Welw.)C.C.Berg)is an endangered multi-use species.Understanding the impact of climate change on the distribution of this species may improve the ability to anticipate or recognize its decline or expansion and to take appropriate conservation measures if necessary.Ecological niche modeling was projected in geographical space to study the current and future distribution of M.excelsa in Bénin.MaxEnt was used to estimate the potential geographic distribution of the species under two Representative Concentration Pathways(RCP).Miroc 5 summaries and two RCP 4.5 and RCP 8.5 scenarios were used as predictor variables for projections of the geographic potential of this species.The performance of the model was assessed by the area under the curve(AUC),true skill statistics(TSS)and partial receiver operating characteristics(Partial ROC).From the results,M.excelsa was more a secondary species in the Guinean climatic zone and part of the Sudanian-Guinean and Sudanian climatic zone.The projections show a signifi cant decrease in suitable habitats for the species from the two RCP scenarios.Only a part of the Guinean climatic zone remained suitable and few protected areas will conserve in situ M.excelsa.For the sustainable conservation of M.excelsa,it is essential to strengthen the protection of sacred forests located in the Guinean climatic zone. | Sunday Berlioz Kakpo Augustin Kossi Nounangnon Aoudji Denis Gnanguènon-Guéssè Alain Jaures Gbètoho Kourouma Koura Géoff roy Kévin Djotan Jean Cossi Ganglo | 2021 | Journal of Forestry Research2021，32，1： | 0 |
| 8 | Research Article Focusing Properties of High-Order Harmonics显示文摘Many applications of the extreme ultraviolet(XUV)radiation obtained by high-order harmonic generation(HHG)in gases require a small focus area in order to enable attosecond pulses to reach a high intensity.Here,high-order harmonics generated in Ar with a multiterawatt laser system in a loose focusing geometry are focused to a few micrometers using two toroidal mirrors in a Wolter configuration with a high demagnification factor.Using a knife-edge measurement technique,we determine the position and size of the XUV foci as a function of harmonic order.We show that the focus properties vary with harmonic order and the generation conditions.Simulations,based on a classical description of the harmonic dipole phase and assuming that the individual harmonics can be described as Gaussian beams,reproduce the experimental behavior.We discuss how the generation geometry affects the intensity and duration of the focused attosecond pulses. | Maria Hoflund Jasper Peschel Marius Plach Hugo Dacasa Kévin Veyrinas Eric Constant Peter Smorenburg Hampus Wikmark Sylvain Maclot Chen Guo Cord Arnold Anne L'Huillier Per Eng-Johnsson | 2021 | Ultrafast Science2021，，1： | 1 |
| 9 | 大喇叭显示文摘这个建筑装置是由Brendeland和Kristoffersen指导,由来自挪威科技大学的一群国际硕士研究生建造完成的.它是一个纪念碑、雕塑、运动场、城市扩音器、扬声器、声音接收器、舞台、电影放映台、遮蔽物、共鸣箱、乐器、一种数学公式、一个感性经验和科学实验的工具、一个再利用的机械零件.这是挪威科技大学送给特隆赫姆市的建校100周年的纪念礼物.地段位于特隆赫姆市历史中心的一个小公园里,旁边是一个中世纪教堂.百年纪念活动结束之后,它将会搬到峡湾一个美丽的、永久的地点,作为大学的百年纪念碑.这个由柱形钢结构支撑的截锥型构筑物,厚3mm,长18m,高6.5m,重达12吨. | Einar Bye Cyril Chabaud Pablo Fernndez Federica Frangipane Styrkaar Hustveit Fanny Jacquet Christian O' Riordan Larsen Quentin Leroy Mélanie Mathevet Runar Nedregàrd Ines Rakow Kévin Sanouiller Valentina Serra Bergur Porsteinsson Martin Bergsmark Vodde Henning Aschim Wien Geir Brendeland Bergur Briem Stig Arne Heltorp | 2014 | 住区2014，，6： | 0 |
| 10 | Torsion of the spermatic cord in adults:a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion显示文摘Acute scrotal pain(AsP)requiring surgical exploration is common in the pediatric population,but little has been reported on this subject with regard to the adult population.The aim of this study was to investigate the demographic and clinical characteristics and outcomes of scrotal explorations performed on adult patients.Patients over 21 years of age who underwent surgical exploration for ASP with suspected testicular torsion(TT)at 14 French hospitals between January 2005 and December 2019 were included in this study.The main outcome measures were demographic characteristics,pathology found during scrotal exploration,and perioperative outcomes.Logistic regression was used to perform univariate and multivariate analyses to identify predictors of TT.Data for 1329 men were analyzed.The median age was 30(interquartile range[IQR]:25-35;range:21-89)years.Regarding the clinical examination,867(65.2%)patients presented with an elevation of the testicle,613(46.1%)patients with scrotal edema or erythema,and 211(15.9%)patients with nausea or vomiting.Operative findings identified TT in only 684(51.5%)patients,epididymo-orchitis in 112(8.4%)patients,a tumor in 16(1.2%)patients,and no causes in 475(35.7%)patients.Orchiectomy for nonviable testes was required in 101(7.6%)patients.In multivariate analysis,an elevation of the testicle,erythema/swelling,and the presence of nausea/vomiting were found to be associated with the occurrence of TT.Testicular torsion is not exclusive to children and adolescents,so must be considered in males of any age with acute scrotal findings.However,one-third of scrotal explorations in adults did not lead to a diagnosis. | Van Thi Dang Benjamin Pradere Anne Mauger de Varennes Nadia Ali Benali Maxime Vallee William Berchiche Bastien Gondran-Tellier Gaelle Margue Clement Michiels Charles Gaillard Tristan Grevez Florian Bardet Maud Hulin Anthony Manuguerra Ugo Pinar Caroline Plassais Margeux Felber William Wandoren Kévin Kaulanjan Ines Dominique Marc Sbizerra Emilien Seizilles de Mazancourt Xavier Matillon Igor Duquesne Maxime Chabenes Victor Gallard Lucas Freton Francois Lannes Zine-Eddine Khene | 2022 | Asian Journal of Andrology2022，24，6： | 1 |
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