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| 1 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 2 | 中国成人糖尿病、血糖与结直肠癌发病率:针对50万人的前瞻性研究显示文摘背景糖尿病可致结直肠癌(CRC)的发病风险升高。糖尿病病程和非糖尿病患者的血糖与CRC发病风险之间的相关性仍不清楚。方法2004至2008年前瞻性中国Kadoofe Biobank研究从10个不同地区纳入了512 713名受试者。在10年随访期间,在基线无癌症史的510 136名受试者中共记录有3 024例新发CRC病例(1 745例结肠癌,1 716例直肠癌)。应用Cox回归分析对糖尿病(入组前诊断或筛查发现的)或无糖尿病病史者随机血糖(RPG)水平与CRC发病相关性的校正风险比(HR)进行估计。结果基线时,共有5.8%的受试者患有糖尿病。糖尿病患者发生CRC的校正HR为1.18(95%可信区间1.04~1.33),且发生结肠癌与直肠癌的风险相当[1.19(1.01~1.39)比1.14(0.96~1135)]。这些患者发生CRC的HR随糖尿病病程的延长而下降(趋势P值为0.03)。在入组前无糖尿病的受试者中,其RPG水平与CRC发病呈正相关,基线RPG每升高1 mmol/L其发生CRC的校正HR为1.04(1.02~1.05),且发生结肠癌与直肠癌的风险亦相当[1.03(1.01~1.05)比1.04(1.02~1.06)]。在男性中,糖尿病和RPG与CRC发病风险的相关性高于女性,但其差异无统计学意义(异质性检验的P值分别为0.3和0.2)。讨论在中国成年人中,未诊断糖尿病者其糖尿病和升高的血糖水平与CRC发病风险升高相关。 | Yuanjie Pang Christiana Kartsonak yu Guo Yiping Chen Ling Yang Zheng Bian Fiona Bragg Iona Y Millwood Leijia Shen Songgen Zhou Jiben Liu Junshi Chen Liming Li Michael V Holmes Zhengming Ghen 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，1： | 6 |
| 3 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 4 | Optimization of HMM Parameters Based on Chaos and Genetic Algorithm for Hand Gesture Recognition显示文摘In order to prevent standard genetic algorithm (SGA) from being premature, chaos is introduced into GA,thus forming chaotic anneal genetic algorithm (CAGA). Chaos' ergodicity is used to initialize the population, and chaoticanneal mutation operator is used as the substitute for the mutation operator in SGA. CAGA is a unified framework of theexisting chaotic mutation methods. To validate the proposed algorithm, three algorithms, i.e. Baum-Welch, SGA andCAGA, are compared on training hidden Markov model (HMM) to recognize the hand gestures. Experiments on twenty-six alphabetical gestures show the CAGA's validity. | Liu Jianghua , Cheng Junshi & Chen Jiapin Information Storage and Research Center, Shanghai Jiaotong University, Shanghai 200030, P. R. China | 2002 | Journal of Systems Engineering and Electronics2002，13，4： | 3 |
| 5 | Cue-triggered activity replay in human early visual cortex显示文摘The recall of learned temporal sequences by a visual cue is an important form of experience-based neural plasticity.Here we observed such reactivation in awake human visual cortex using intracranial recording.After repeated exposure to a moving dot,a flash of the dot was able to trigger neural reactivation in the downstream receptive field along the motion path.This effect was observed only when the cue appeared near the receptive field.The estimated traveling speed was faster compared to the activation induced by the real motion.We suggest a range-limited,time-compressed reactivation as a result of repeated visual exposure in awake human visual cortex. | Junshi Lu Lu Luo Qian Wang Fang Fang Nihong Chen | 2021 | Science China(Life Sciences)2021，64，1： | 2 |
| 6 | Associations of muscle mass,strength,and quality with all-cause mortality in China:a population-based cohort study显示文摘Background It remains unclear about the association of muscle mass,strength,and quality with death in the general Chinese population of diverse economical and geographical backgrounds.The present study aimed to comprehensively examine such associations across different regions in China.Methods Based on the China Kadoorie Biobank study,the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or cancer.Muscle mass and grip strength were measured using calibrated instruments.Arm muscle quality was defined as the ratio of grip strength to arm muscle mass.Low muscle mass,grip strength,and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index,grip strength,and arm muscle quality,respectively.Cox proportional hazards models yielded hazard ratios(HRs)and 95%confidence intervals(CIs)for risks of all-cause mortality in relation to muscle mass,strength,and quality.Results During a median follow-up of 3.98 years,739 participants died.The HR(95%CI)of all-cause mortality risk was 1.28(1.08–1.51)for low appendicular muscle mass index,1.38(1.16–1.62)for low total muscle mass index,1.68(1.41–2.00)for low grip strength,and 1.41(1.20–1.66)for low arm muscle quality in models adjusted for sociodemographic characteristics,lifestyle factors,and medical histories.Conclusion Low muscle mass,grip strength,and arm muscle quality are all associated with short-term increased risks of mortality,indicating the importance of maintaining normal muscle mass,strength,and quality for general Chinese adults. | Man Wu Yuxia Wei Jun Lv Yu Guo Pei Pei Jiachen Li Huaidong Du Ling Yang Yiping Chen Xiaohui Sun Hua Zhang Junshi Chen Zhengming Chen Canqing Yu Liming Li 无 | 2022 | Chinese Medical Journal2022，，11： | 2 |
| 7 | Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis显示文摘 | Xiaoyu Zhang Junshi Yazaki Ambika Sundaresan Shawn Cokus Simon W.-L. Chan Huaming Chen Ian R. Henderson Paul Shinn Matteo Pellegrini Steve E. Jacobsen Joseph R. Ecker | 2006 | Cell2006，，6： | 2 |
| 8 | Studied on the effectiveness of NaFeEDTA fortified soy sauce in con- trolling iron deficiency : a population - based intervention trial显示文摘 | CHEN Junshi ZHAO Xianfeng ZHANG Xin | 2005 | Food Nutr Bull2005，26，2： | 1 |
| 9 | High‑Performance Flexible Microneedle Array as a Low‑Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography显示文摘Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications.Existing schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider applications.Here,we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface,robustness of microneedles to penetrate the skin without fracture,and a simplified process to allow mass production.The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording.The normalized electrode–skin contact impedance reaches 0.98 kΩcm^(2)at 1 kHz and 1.50 kΩcm^(2)at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard electrodes.The morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized.The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes. | Junshi Li Yundong Ma Dong Huang Zhongyan Wang Zhitong Zhang Yingjie Ren Mengyue Hong Yufeng Chen Tingyu Li Xiaoyi Shi Lu Cao Jiayan Zhang Bingli Jiao Junhua Liu Hongqiang Sun Zhihong Li | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 10 | Dietary Changes and Disease Transition in China显示文摘 | JUNSHI CHEN | 2002 | Nutrition2002，15，4： | 1 |
| 11 | Essential role of medicine and food homology in health and wellness显示文摘Traditional Chinese medicine(TCM)is an ancient healing system that has been practiced for thousands of years in China and other East Asian countries.According to the TCM theory,medicine and food share the same origin and may have the same functions in the prevention and treatment of various health conditions.This is how the concept of medicine and food homology is developed and popularized. | Junshi Chen | 2023 | Chinese Herbal Medicines2023，15，3： | 1 |
| 12 | A novel remote sensing image classification scheme based on data fusion, multiple features and ensemble learning显示文摘 | Du Peijun Chen Yu Xia Junshi | 2013 | J Indian Soc Remote sensing2013，41，2： | 1 |
| 13 | A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats显示文摘 | JIA Xudong LINing CHEN Junshi | 2005 | Life Sci2005，76，17： | 1 |
| 14 | Studied on the effectiveness of NaFeEDTA aified soy sauce in controlling iron deficiency : a population - based intervention trial 显示文摘 | CHEN Junshi ZHAO Xianfeng ZHANG Xin | 2005 | Food Nutr Bull2005，26，2： | 1 |
| 15 | Preparation and application of TiO2 photocatalytic sensor for chemical oxygen demand determination in water research显示文摘 | Litong Jin Junshi Chen Jidong Zhang | 2005 | Water Research2005，39，： | 1 |
| 16 | Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank显示文摘 | Sarah Lewington Liming Li Paul Sherliker Yu Guo Iona Millwood Zheng Bian Gary Whitlock Ling Yang Rory Collins Junshi Chen Xianping Wu Shaojie Wang Yihe Hu Li Jiang Liqiu Yang Ben Lacey Richard Peto Zhengming Chen | 2012 | Journal of Hypertension2012，，7： | 1 |
| 17 | Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis显示文摘 | Xiaoyu Zhang Junshi Yazaki Ambika Sundaresan Shawn Cokus Simon W.-L. Chan Huaming Chen Ian R. Henderson Paul Shinn Matteo Pellegrini Steve E. Jacobsen Joseph R. Ecker | 2006 | Cell2006，，6： | 1 |
| 18 | Studied on the effectiveness of NaFeEDTA-fortified soy sauce in controlling iron defieiency: a population-based intervention trial 显示文摘 | CHEN Junshi ZHAO Xianfeng ZHANG Xin | 2005 | Food Nutr Bull2005，26，2： | 1 |
| 19 | Hybrid Genetic Algorithm Based Optimization of Coupled HMM for Complex Interacting Processes Recognition显示文摘Coupled Hidden Markov Model (CHMM) is the extension of traditional HMM, which is mainly used for complex interactive process modeling such as two-hand gestures. However, the problems of finding optimal model parameter are still of great interest to the researches in this area. This paper proposes a hybrid genetic algorithm (HGA) for the CHMM training. Chaos is used to initialize GA and used as mutation operator. Experiments on Chinese TaiChi gestures show that standard GA (SGA) based CHMM training is superior to Maximum Likelihood (ML) HMM training. HGA approach has the highest recognition rate of 98.0769%, then 96.1538% for SGA. The last one is ML method, only with a recognition rate of 69.2308%. | 刘江华 Chen Jiapin Cheng Junshi | 2004 | High Technology Letters2004，10，3： | 1 |
| 20 | Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters 显示文摘 | Li Ning Han chi Chen Junshi | 1999 | Nutr Cancer1999，35，1： | 1 |
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