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| 1 | The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility显示文摘Objective: To examine the effect of pSer9-GSK-3β on breast cancer and to determine whether the underlying metabolic and immunological mechanism is associated with ROS/eIF2B and natural killer(NK) cells.Methods: We employed TWS119 to inactivate GSK-3β by phosphorylating Ser9 and explored its effect on breast cancer and NK cells. The expression of GSK-3β, natural killer group 2 member D(NKG2D) ligands, eIF2B was quantified by PCR and Western blot. We measured intracellular reactive oxygen species(ROS) and mitochondrial ROS using DCFH-DA and MitoSOX^(TM) probe,respectively, and conducted quantitative analysis of cellular respiration on 4T1 cells with mitochondrial respiratory chain complex Ⅰ/Ⅲ kits.Results: Our investigation revealed that TWS119 downregulated NKG2D ligands(H60 a and Rae1), suppressed the cytotoxicity of NK cells, and promoted the migration of 4T1 murine breast cancer cells. Nevertheless, LY290042, which attenuates p-GSK-3β formation by inhibiting the PI3K/Akt pathway, reversed these effects. We also found that higher expression of p Ser9-GSK-3β induced higher levels of ROS, and observed that abnormality of mitochondrial respiratory chain complex Ⅰ/Ⅲ function induced the dysfunction of GSK-3β-induced electron transport chain, naturally disturbing the ROS level. In addition, the expression of NOX3 and NOX4 was significantly up-regulated, which affected the generation of ROS and associated with the metastasis of breast cancer. Furthermore, we found that the expression of pSer535-eIF2B promoted the expression of NKG2D ligands(Mult-1 and Rae1) following by expression of pSer9-GSK-3β and generation of ROS.Conclusions: The PI3K/Akt/GSK-3β/ROS/eIF2B pathway could regulate NK cell activity and sensitivity of tumor cells to NK cells,which resulted in breast cancer growth and lung metastasis. Thus, GSK-3β is a promising target of anti-tumor therapy. | Fengjiao Jin Zhaozhen Wu Xiao Hu Jiahui Zhang Zihe Gao Xiao Han Junfang Qin Chen Li Yue Wang | 2019 | Cancer Biology & Medicine2019，16，1： | 20 |
| 2 | I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘 | Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han | 2014 | Cellular & Molecular Immunology2014，11，2： | 14 |
| 3 | Value of magnetic resonance imaging including dynamic contrast-enhanced magnetic resonance imaging in differentiation between inverted papilloma and malignant tumors in the nasal cavity显示文摘 | Wang Xinyan Zhang Zhengyu Chen Xiaoli Li Jing Xian Junfang | 2014 | Chinese Medical Journal2014，，9： | 13 |
| 4 | Two-photon-excited near-infrared emissive carbon dotsas multifunctional agents for fluorescence imaging andphotothermal therapy显示文摘C dots (CDs) have shown great potential in bioimaging and phototherapy.However, it is challenging to manipulate their fluorescent properties andtherapeutic efficacy to satisfy the requirements for clinic applications. In thisstudy, we prepared S, Se-codoped CDs via a hydrothermal method anddemonstrated that the doping resulted in excitation wavelength-independentnear-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm.Significantly, the CDs exhibited a photothermal conversion efficiency of -58.2%,which is the highest reported value for C nanostructures and is comparable tothat of Au nanostructures. Moreover, the CDs had a large two-photon absorptioncross section (-30,045 GM), which allowed NIR emissions and the photothermalconversion of the CDs through the two-photon excitation (TPE) mechanism. Invitro and in vivo tests suggested that CDs can function as new multi functionalphototheranostic agents for the TPE fluorescence imaging and photothermaltheraov of cancer cells. | Minhuan Lan Shaojing Zhao Zhenyu Zhang Li Yan Liang Guo Guangle Niu Jinfeng Zhang Junfang Zhao Hongyan Zhang Pengfei Wang Guangyu Zhu Chun-Sing Lee Wenjun Zhang | 2017 | Nano Research2017，10，9： | 9 |
| 5 | Heavy metal(loid) pollution in mine wastes of a Carlin-type gold mine in southwestern Guizhou, China and its environmental impacts显示文摘Mercury pollution resulting from artisanal gold mining is a serious environmental problem in many developing countries. In this study, we analyzed heavy metal(loid) contamination in mine wastes from a Carlin-type gold mine in southwestern Guizhou, China. Highly elevated levels of As, Hg, Tl, Sb, and Cd—up to 5844, 28,29, 581 and 3.0 mg/kg, respectively—were observed in the mine wastes, but no significant accumulation of Cr, Ni, Cu,Zn, and Pb was found. The smelting process of gold ores had significant impacts on the enrichment of As, Tl, and Hg in the mine wastes. Due to the significant metal(loid)pollution in this gold mine, the ecological risks are classified as ‘‘very high.'' Hg and As are the major pollutants with a relative contribution of 55.9 % and 24.2 % to the risk index, respectively. Phytoremediation could be used to reduce heavy metal contamination and recycle the gold simultaneously. Hg–As–Tl pollution should be considered in gold extraction at Carlin-type gold mines. | Ping Li Junfang Zhang Jianxu Wang Zhonggen Li | 2015 | Chinese Journal Of Geochemistry2015，34，3： | 9 |
| 6 | Synthesis,luminescent properties,and theoretical study of novel Sm^(3+) and Dy^(3+) complexes containing β-diketone and 1,10-phenanthroline显示文摘Two new ternary complexes of 1-(2-thienyl)-3-(p-phenylethynylphenyl)-1,3-propanedione(HTPP) and 1,10-phenanthroline(phen) with Sm3+ and Dy3+ were synthesized.The composition of the ternary complexes was characterized as Sm(TPP)3phen and Dy(TPP)3phen,respectively,by infrared(IR) spectra,chemical analysis,elemental analysis,and thermodynamic analysis.At room temperature,under UV light excitation,the Sm3+ and Dy3+ complexes exhibit characteristic emissions of the central ions.It is found that the fluorescence intensity of Sm(TPP)3phen is stronger than that of Dy(TPP)3phen.In order to explain this phenomenon,an accurate quantum chemistry calculation was carried out,and the result is in good agreement with the experiment data. | LIU Xingwang GAO Saishengtai WANG Li SHEN Leijun JIANG Jiadong GAO Junfang | 2011 | Rare Metals2011，30，1： | 7 |
| 7 | Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies显示文摘 | Liu Yuhe Xue Junfang Zhao Danhua Chen Li Yuan Yun Wang Zhaoxia | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 8 | SOA-based RFID public services infrastructure:architecture and its core services显示文摘Radio frequency identification(RFID)has prominent advantages compared with other autoidentification technologies.Combining RFID with network technology,physical object tracking and information sharing can possibly be carried out in an innovative way.Regarding open-loop RFID applications,RFID public services infrastructure(PSI)is presented,PSI architecture is designed,and service modules are implemented,and a demonstrative application system,blood management and traceability system,is studied to verify PSI.Experimental results show the feasibility of the proposed architecture and the usability of PSI framework software. | Zeng Junfang Li Ran Luo Jin Liu Yu | 2009 | Journal of Systems Engineering and Electronics2009，20，3： | 5 |
| 9 | Synthesis and facet-dependent photocatalytic activity of strontium titanate polyhedron nanocrystals显示文摘Cubic-perovskite (SrTiO 3) 有一个大潜力在大量应用被利用。然而,当前,很,很少在他们的物理化学的性质上对形状和 SrTiO 3 的方面效果被知道。这大部分由于在在合成期间控制方面的形态学的困难。此处,我们为 singlecrystalline SrTiO 3 的控制方面、控制尺寸的制造描述一条灵巧的线路三角形的棱柱与高度暴露了 { 101 } 方面脸并且 { 111 } 结束脸。他们的 photocatalytic 表演的理论、试验性的研究证明了三角形的棱柱比 nanocubes 展出优异 photocatalytic 活动与暴露( 001 )为器官的沾染物的降级面对,它可以首先被归因于高得多的表面精力{ 101 }方面( 2.97 J/m 2)并且{ 111 }方面( 2.80 J/m 2)比的{ 001 }方面( 0.98 J/m 2)。 | Junfang Li Hua Bai Wencai Yi Jingyao Liu Yahui Li Qing Zhang Haifeng Yang Guangcheng Xi | 2016 | Nano Research2016，9，5： | 4 |
| 10 | Growth,Nitrogen Uptake and Flow in Maize Plants Affected by Root Growth Restriction显示文摘The objective of the present study was to investigate the influence of a reduced maize root-system size on root growth and nitrogen(N) uptake and flow within plants.Restriction of shoot-borne root growth caused a strong decrease in the absorption of root:shoot dry weight ratio and a reduction in shoot growth.On the other hand,compensatory growth and an increased N uptake rate in the remaining roots were observed.Despite the limited long-distance transport pathway in the mesocotyl with restriction of shoot-borne root growth,N cycling within these plants was higher than those in control plants,implying that xylem and phloem flow velocities via the mesocotyl were considerably higher than in plants with an intact root system.The removal of the seminal roots in addition to restricting shoot-borne root development did not affect whole plant growth and N uptake,except for the stronger compensatory growth of the primary roots.Our results suggest that an adequate N supply to maize plant is maintained by compensatory growth of the remaining roots,increased N uptake rate and flow velocities within the xylem and phloem via the mesocotyl,and reduction in the shoot growth rate. | Liangzheng Xu Junfang Niu Chunjian Li Fusuo Zhang | 2009 | Journal of Integrative Plant Biology2009，51，7： | 4 |
| 11 | Farmland mercury contamination in the vicinity of an organic chemical factory in Guizhou,China显示文摘This study assesses the level of contamination of Hg in farmland soils along the irrigating channel down-stream from Guizhou Organic Chemical Factory (GOCF),where metallic mercury is used as a catalyst to produce acetic acid. The total input of mercury into the environment,as announced by GOCF,is 140 t in the past 30 years (1971-2000). Sampling sites were chosen based on the distance from the source of pollution—the chemical factory. A total of 39 samples were collected from the study area and analyzed for total mercury concentrations and methyl mercury concentrations. The characteristics of vertical and horizontal distributions of total mercury and methyl mer-cury in the study area (farmland) are described in this paper. Much attention was paid to the transformation of inor-ganic Hg into organic mercury species in soils as well. The results showed that the farmland has been heavily con-taminated by Hg. Land cultivation activity,land utilization style and distance from the pollution source could be the dominant factors controlling the distribution of THg and MeHg. It is observed that active transformation of inorganic Hg into organic mercury species (MeHg) usually takes place in paddy soils. | ZHANG Junfang QU Liya FENG Xinbin ZHANG Wei GUO Yanna LIN Kai LI Mei | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 3 |
| 12 | 用高压氧治疗高原脱习服症的效果分析显示文摘目的:探讨用高压氧治疗高原脱习服症的临床效果。方法:对近期结束高原防守任务后赴临潼疗养院进行疗养治疗的31例高原官兵的临床资料进行回顾性研究。我们将这31例患者分为高压氧组和康复疗养组,其中,高压氧组有18例患者,康复疗养组有13例患者。我院对康复疗养组的患者进行康复疗养,在此基础上,对高压氧组的患者进行高压氧治疗。我们在患者入院时、进行治疗后的15天及30天记录其临床症状,并对其临床症状的改善情况进行评分,比较两组患者的评分结果。结果:在治疗后15天后,高压氧组患者的高原脱习服症状评分明显低于康复疗养组的患者,二者相比差异有显著性(P<0.05)。结论:在进行康复疗养的基础上用高压氧治疗高原脱习服症可明显地改善患者的症状。但该方法的治疗效果及成熟的治疗方案尚待进一步的研究。 | 哈振德 Xu Li Shi Runze Guo Guanghui Song Wei Wang Junfang Zhang Quan | 2014 | 当代医药论丛2014，12，14： | 3 |
| 13 | Cyclopalladated ferrocenylimines as efficient catalysts for homogeneous catalysis:A brief introduction to our preliminary achievements显示文摘Cyclopalladated ferrocenylimines as a novel kind of highly efficient palladium catalyst precursors, which are air-stable and easy to handle, have been successfully applied in a wide variety of catalytic reactions ranging from classical reactions, such as Heck, Suzuki, Sonogashira and Buchwald-Hartwig couplings, to cyanation, addition reactions of arylboronic acids, and coupling reactions involving terminal alkynes. The preliminary achievements regarding their applications to homogeneous catalysis are concisely described herein. | WU YangJie YANG Fan ZHANG JinLi CUI XiuLing GONG JunFang SONG MaoPing LI TieSheng | 2010 | Chinese Science Bulletin2010，55，25： | 2 |
| 14 | Hepatitis C and Alcohol Exacerbate Liver Injury by Suppression of FOXO3显示文摘 | Batbayar Tumurbaatar Irina Tikhanovich Zhuan Li Jinyu Ren Robert Ralston Sudhakiranmayi Kuravi Roosevelt Campbell Gaurav Chaturvedi Ting-Ting Huang Jie Zhao Junfang Hao Maura O’Neil Steven A. Weinman | 2013 | The American Journal of Pathology2013，，6： | 2 |
| 15 | Analyzing Asymmetric City Connectivity by Toponym on Social Media in China显示文摘The connectedness between cities has become one of the most widely discussed topics in urban and regional research in the mobile and big data era. One problem identified is the asymmetric city connectivity, partially due to data availability. We present a data-driven approach based on location and toponym(place name) extracted from social media data, to assess the asymmetric connectivity between cities. The assumption is that a higher frequency of occurrences of the name of city i in posts located in city j would imply that the city i is more influential than other cities upon city j. In addition, we’ve developed a group of measurements such as the relatedness index, impact index, link strength index, dependence index, and structure similar index to characterize such interactions. This framework of connectivity measurements can also be used to support smart planning taking into account the evolving interplay among cities. The space-time structure of urban systems in China is examined as the case study. | YE Xinyue GONG Junfang LI Shengwen | 2021 | Chinese Geographical Science2021，31，1： | 2 |
| 16 | Control of static unstable airframes显示文摘The challenge and control problems of static unstable missiles are presented. The steady-state benefits of static instability are illustrated, while the corresponding control challenge is described both by the characteristic lag of airframe and the increment of necessary control usage. Control limitation led by unstable zero-pole pair is analyzed for preliminary design and evaluation. Linear control strategy is examined wherein two and three loop acceleration autopilots with different control usages are developed using an optimal control approach combined with frequency domain constraint. The weights selection and relation with system performance are detailed. Then the nonlinear backstepping recursive method is detailed to determine how well it is able to follow command and its engineering feasibility. The results show that a static unstable missile is controllable, while the actuator bandwidth is the crucial limited factor. There should be a compromise between overall performance and actuator payment. | Junfang Fan Defu Lin Zhong Su Qing Li | 2010 | Journal of Systems Engineering and Electronics2010，21，6： | 2 |
| 17 | Wire-in-Wire TiO_(2)/C Nanofibers Free-Standing Anodes for Li-Ion and K-Ion Batteries with Long Cycling Stability and High Capacity显示文摘Wearable and portable mobile phones play a critical role in the market, and one of the key technologies is the flexible electrode with high specific capacity and excellent mechanical flexibility. Herein, a wire-in-wire TiO_(2)/C nanofibers (TiO_(2) ww/CN) film is synthesized via electrospinning with selenium as a structural inducer. The interconnected carbon network and unique wire- in-wire nanostructure cannot only improve electronic conductivity and induce effective charge transports, but also bring a superior mechanic flexibility. Ulti-mately, TiO_(2) ww/CN film shows outstanding electrochemical performance as free-standing electrodes in Li/K ion batteries. It shows a discharge capacity as high as 303 mAh g^(−1) at 5 A g^(−1) after 6000 cycles in Li half-cells, and the unique structure is well-reserved after long-term cycling. Moreover, even TiO_(2) has a large diffusion barrier of K^(+), TiO_(2) ww/CN film demonstrates excellent perfor-mance (259 mAh g^(−1) at 0.05 A g^(−1) after 1000 cycles) in K half-cells owing to extraordinary pseudocapacitive contribution. The Li/K full cells consisted of TiO_(2) ww/CN film anode and LiFePO_(4)/Perylene-3,4,9,10-tetracarboxylic dianhydride cathode possess outstanding cycling stability and demonstrate practical application from lighting at least 19 LEDs. It is, therefore, expected that this material will find broad applications in portable and wearable Li/K-ion batteries. | Die Su Yi Pei Li Liu Zhixiao Liu Junfang Liu Min Yang Jiaxing Wen Jing Dai Huiqiu Deng Guozhong Cao | 2021 | Nano-Micro Letters2021，13，7： | 2 |
| 18 | A New Growth Model of Fault Attributes in a Strike-Slip Fault System in the Tarim Basin显示文摘Fault attributes generally display a consistent power–law-scaling relationship.Based on new 3 D seismic data,however,we found some exceptional fault attribute relationships of lengths(L)–throw(T)(vertical component of displacement),overlap zone length(Lo)–width(Wo)from a strike-slip fault system of the Ordovician carbonates in the Tarim Basin.The L–T relationship shows two linear segments with breakup at^40 km in fault length.This presents an exceptional throw increase in the second stage,which is attributed to a localization of vertical displacement and deformation in overlapping zones other than the different fault scales in a mature fault zone.The Lo–Wo relationship in the overlapping zones shows multiply stepped-shape patterns,suggesting multiple fault differential growth and periodic increase in fault size.Therefore,we propose a new alternative growth model of fault attributes in strike-slip fault zones,in which the overlapping zones accumulated localized displacement and deformation in the intracratonic strike-slip fault zone. | ZHANG Yintao WU Guanghui WANG Junfang LI Guohui WAN Xiaoguo YANG Tianyi | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 19 | Application Status and Prospects of Biogas Fertilizer in Modern Agricultural Production显示文摘On the basis of introducing the nutrient composition and biogas fertilizer,the effects of biogas fertilizer on soil,crops and environment are summarized. Biogas fertilizer can improve soil structure,increase soil organic matter,available nutrient contents and enzyme activity,increase crop yield,quality and resistance,and relieve the non-point source pollution effectively. The harmlessness,application technology and risk are analyzed. Some suggestions are put forward to control the source pollution,strengthen the research of fermentation technology,define the standard of biogas fertilizer,and carry out large and medium-sized biogas engineering. | Jianshuo SHI Junfang YANG Liying WANG Li GUO Yanli REN Ruonan LI Fengzhi ZHAI Xuan SUN | 2018 | Asian Agricultural Research2018，10，7： | 1 |
| 20 | Electronic and elastic properties of LisN under different pressure显示文摘 | Li Wei Chen Junfang Wang Teng | 2010 | Physica B2010，405，1： | 1 |
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