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| 1 | The association between the genetic polymorphisms of LMP2/LMP7 and the outcomes of HCV infection among drug users显示文摘Objective:To investigate a possible association of LMP2/LMP7 genes with chronic hepatitis C virus(HCV) infection,and to assess whether LMP2/LMP7 genes could influence the outcomes of HCV infection among drug users.Methods:Genomic DNAs of 362 anti-HCV sero-positive drug users and 225 control drug users were extracted from the peripheral blood leukocytes.The sero-positive patients were divided into those who had persistent infection and those who had spontaneously cleared the infection.Polymorphisms of LMP genes were determined by PCR combined with restriction fragment length polymorphism(RFLP).Results:The distribution of LMP2 genotypes among the control,persistent infection and spontaneous clearance groups were not different.However,the LMP7 codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in control group(OR=1.75,95%CI=1.06~2.90;OR=3.16,95%CI=1.23-8.12;OR=1.94,95%CI=1.21-3.12,respectively).Similarly,the frequencies of the codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in the spontaneous clearance group(OR=1.64,95%CI=1.04-2.57;OR=2.40,95%CI=1.09-5.28;OR=1.76,95%CI=1.152.69,respectively).Stratified analysis indicated that combined genotype Gln/Lys+Lys/Lys of the LMP7 gene was related to an increasing susceptibility to HCV infection(OR=1.91,95%CI=1.02-3.55;OR=2.19,95%CI=1.243.89;OR=1.91,95%CI=1.05-3.48,OR=2.86,95%CI=1.41-5.78,respectively)and the risk of persistent HCV infection(OR=1.94,95%CI=1.12-3.34;OR=2.02,95%CI=1.21-3.38;OR=1.78,95%CI=1.12-2.85,OR=2.23,95%CI=1.09-4.58,respectively)among>30-year-old,males,the injection drug user(IDU)subjects and/or the shorter duration drug users(≤5 y).Conclusion:These results suggest that polymorphism of the LMP7 gene may have an influence on the outcomes of HCV infection,and is one of the factors accounting for the genetic susceptibility to HCV infection among drug users. | Qian Cui Yongxiang Zhang Jing Su Chao Shi Na Lei Keqin Ding Jun Li Rongbin Yu L u Wang Ning Wang | 2010 | The Journal of Biomedical Research2010，24，5： | 6 |
| 2 | Automated Sequencing and Subassembly Detection in Automobile Body Assembly Planning显示文摘The choice of the sequence in which parts or subass em blies are put together in the mechanical assembly of a product can drastical ly affect the efficiency of the assembly process. Unlike metal cutting operation s where computer aided system have been available for some 15 to 25 years to hel p manufacturing engineers in generating cutting sequences and NC programs, the m ajority of assembly planning tasks in automobile body design is still manually p erformed by assembly designers according to their past experiences. This has prolonged the production lead time and time to market. This paper describes a p rocedure to automatically derive all the feasible assembly sequences for automob ile body assembly. The procedure is based on a mathematical model of the automob ile body, obtained through the definitions of the connection matrix and contract ed matrix. These two matrices represent the precedence constraint knowledge amon g components and subassemblies. The possible subassemblies are automatically det ected by satisfying some mathematical conditions applicable to these matrices. F or each subassembly and the whole product, all the possible assembly sequences a re generated by rearranging the initial connection sub-matrix and the contracte d matrix. The procedure is applicable to compliant component assemblies, suc h as the automobile body assembly, aircraft frame assembly, and can solve the 'combinatorial explosion' problem efficiently. | ZHANG Yi-zhu 1, NI Jun 2, LIN Zhong-qin 1, LAI Xin-min 1 (1. Institute of Mechanics and Engineering, Shanghai Jiaotong Universit y, Shanghai 200030, China 2. Department of Mechanical Engineering, The University of Michigan, Michigan, U SA) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 3 |
| 3 | Serum Contents of the Free Forms of α1-Microglobulin and Ulinastatin: Relation to Diseased States in Patients with Mood Disorders 显示文摘 | Tadahiro S Koichi K Jun U | 2001 | Neuropsychobiolgy2001，43，： | 1 |
| 4 | NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter显示文摘 | JUN C H LEE T S SOHN U D | 2003 | Auton Autacoid Pharmacol2003，23，3： | 1 |
| 5 | Analytic thermogravimetry to determine the effect of surface modification on dispersion of NdFeB fillers 显示文摘 | Joshua U O | 1999 | J Mater Res1999，14，7： | 1 |
| 6 | Measurement of human hepatic and splenic perfusion using dynamic computed tomography:a preliminary report显示文摘 | Yoshito T Yasushi U Jun K | 1998 | Computer Methods and Programs in Biomedicine1998，57，2： | 1 |
| 7 | Modeling of magnetic properties of polymer bonded Nd-Fe-B magnets with surface modifications 显示文摘 | Joshua U O David C J | 2000 | Journal of Magnetism and Magnetic Materials2000，218，： | 1 |
| 8 | Synthesis and characterization of copper sulfide nanocrystallites with low sintering temperatures显示文摘 | Shan Jun Pulkkinen P Vainio U | 2008 | J Mater Chem2008，18，27： | 1 |
| 9 | Hemicellulose extraction from aspen chips prior to kraft pulping utilizing kraft white liquor显示文摘 | Jun A Tschirner U W Tauer Z | 2012 | Biomass and Bioenergy2012，37，： | 1 |
| 10 | 显示文摘 | Meng C L Jun Y U | 2005 | Materials Transactions2005，46，6： | 1 |
| 11 | A nonrational Bspline profiled horn with high displacement amplification for ultrasonic welding显示文摘 | HUU T N HAI D N JUN Y U | 2014 | Ultrasonics2014，54，8： | 1 |
| 12 | Neopeptins A, B, C, Inhibitors of fungal cell wall glucan synthasls 显示文摘 | Makoto U Masakazu J Jun U | 1986 | Agr Biol Chem1986，5，2： | 1 |
| 13 | The effects of a selective inhibitor of C- Fos/activator protein- 1 on endotoxin-indueed acute kidney injury in mice显示文摘 | Hiroyuki M Jun M Masaaki U | 2012 | BMC Nephrology2012，13，1： | 1 |
| 14 | Diagnostic and molec- ularevaluation of three iridoviruassociated salamander mortality events显示文摘 | Douglas E D Carol U M Jun W | 2003 | J Wildl Dis2003，39，3： | 1 |
| 15 | Comparison of effects of alendronate and raloxifene on lumbar bone mineral mdensity,boneturnover,and lipid metabolism in elderly women with osteoporosis显示文摘 | Jun I Yoshihiro S Mitsuyoshi U | 2008 | Yonsei Med J2008，49，： | 1 |
| 16 | A comparison of three cell types as potential candidates for intervertebral disc thera- py: annulus fibrosus cells, chondrocytes, and bonemarrow de- rived cells显示文摘 | SUNG U K YERUN Z JUN L | 2009 | Joint Bone Spine2009，76，： | 1 |
| 17 | Gas sorption and transport in coals:a poroelastic medium approach显示文摘 | JUN Y Y(U)CEL A I (O)ZGEN K C | 2009 | International Journal of Coal Geology2009，77，12： | 1 |
| 18 | Metabolomic profiling of a modified alcohol liquid diet model for liver injmy in the mouse uncovers new markers of disease显示文摘 | Gltfir U Bradford Tlmmas M O'Connell Jun ttan el M | 2008 | Toxicology and Applied Pharmacology2008，232，： | 1 |
| 19 | Quantitation of neonicotinoid metabolites in human urine using GC-MS显示文摘 | Hiroshi N Jun U Takaaki K | 2013 | J Chromatogr B2013，941，： | 1 |
| 20 | Robust H non-fragile control design for descriptor delay systems 显示文摘 | Yu S Yu Z U Jun Y | 2012 | Applied Mathematical Sciences2012，6，28： | 1 |
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