| 1 | TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer显示文摘Gastric can cer is one of the most comm on cancers worldwide and is the third leadi ng cause of cancer-related deaths globally. Although significant progress has been made in the diagnosis and treatment for the cancer, less improvement has been made in overall survival rate. Thus, there is an urgent need for a better understanding of the biological aspects of the cancer. The transcription factor transcription factor 7-like 1 (TCF7L1) is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in gastric cancer has seldom been discussed. In the present study, by using the Cancer Genome Atlas dataset analysis, we demonstrated that patients with higher expression of TCF7L1 could be used to reflect prognosis. An examination of the mechanisms demonstrated that TCF7L1 could positively regulate antioxidant response in gastric cancer cells by positively regulating Keap1/NRF2 [Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2] pathway. Collectively, our data demonstrated that TCF7L1 is a novel marker for predicting overall survival of gastric cancer and provided the possible underlying molecular mechanism. | Beili Zhang Jugang Wu Yantao Cai Meng Luo Bing Wang Yan Gu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员