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| 1 | Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection显示文摘The role of IL-17A is important in protection against lung infection with Chlamydiae,an obligate intracellular bacterial pathogen.In this study,we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity.We found thatγδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection,respectively.Depletion ofγδT cells in vivo at the early postinfection(p.i.)stage,when mostγδT cells produce IL-17A,failed to alter Th1 responses and bacterial clearance.In contrast,the blockade of IL-17A at the time when IL-17A was mainly produced by Th17(day 7 p.i.)markedly reduced the Th1 response and increased chlamydial growth.The data suggest that theγδT cell is the highest producer of IL-17A in the very early stages of infection,but the protection conferred by IL-17A is mainly mediated by Th17 cells.In addition,we found that depletion ofγδT cells reduced IL-1αproduction by dendritic cells,which was associated with a reduced Th17 response.This finding is helpful to understand the variable role of IL-17A in different infections and to develop preventive and therapeutic approaches against infectious diseases by targeting IL-17A. | Hong Bai Xiaoling Gao Lei Zhao Ying Peng Jie Yang Sai Qiao Huili Zhao Shuhe Wang YiJun Fan Antony George Joyee Zhi Yao Xi Yang | 2017 | Cellular & Molecular Immunology2017，14，10： | 7 |
| 2 | Vacuum electronic high power terahertz sources显示文摘 | BOOSKE J DOBBS R JOYE C | | 0，，01： | 3 |
| 3 | Induction of replication in human corneal endothelial cells by E2F2 transcription factor eDNA transfer显示文摘 | McAlister JC Joyee NC Harris DL | 2005 | Invest Ophthalmol Vis Sci2005，46，： | 1 |
| 4 | Estimating the carbon footprint of telecommunications products: a heuris- tic approach显示文摘 | JOYEE T OKRASINSKI T A SCHAEFFER W | 2010 | Jorunal of Mechanical Design2010，132，9： | 1 |
| 5 | Effects of l-methyleyclopropene alone and in combination with polyethylene bags on the postharvest life of mango fruit显示文摘 | Jiang Y Joyee D C | 2000 | Annals of Applied Biology2000，137，3： | 1 |
| 6 | Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure显示文摘 | Letavemier E Perez J Joye E | | 0，，08： | 1 |
| 7 | National Pressure Ulcer Advi-sory Panel, Updated Pressure Ulcer Staging System 显示文摘 | Joyee B Laura E Ceoree T | 2007 | UrolNurs2007，27，4： | 1 |
| 8 | Diffuse proliferative lupus nephritis : identification of specific pathologic features affect- ing renal outcome显示文摘 | Austin H A Muenz L R Joyee K M | 1984 | Kidney Int1984，25，4： | 1 |
| 9 | Effect of L-Carnitine on nucleic acid status of aged rat brain显示文摘 | PACKIASAMY A R JULIT A G JOYEE | 2004 | Experimental Neurology2004，，191： | 1 |
| 10 | Best practices in second stage labor care: r~atemal beating down and positioning 显示文摘 | Joyee Roberts Lisa Hanson | 2007 | J Midwifery Womens Health2007，52，3： | 1 |
| 11 | Spermicidal and anti - Trichomonas vaginalis activity of Brazilian Sapindus saponaria 显示文摘 | Edilson Damke Joyee K Tsuzuki Francieli Chassot | 2013 | Complementary and Altemative Medicine2013，13，7： | 1 |
| 12 | Human recombinant activated C in meningococcal sepsis显示文摘 | Wcisel G Joyee D Gudmundsdottir C | 2002 | Chest2002，121，1： | 1 |
| 13 | Distinct NKT cell subsets are induced by different chlamydia species leading to differential adaptive immunity and host resistance to the infections显示文摘 | Joyee AG Qiu H Wang S | 2007 | J Immnol2007，178，2： | 1 |
| 14 | Staging and defining characteristics of pressure ulcers using photographs by staff nurses in acute care settings显示文摘 | Elizabeth CJ Joan IW Joyee EJ | 2013 | J Wound Ostomy Continence Nurs2013，40，2： | 1 |
| 15 | Plasmacytoid dendritic cells mediate the regulation of inflammatory type T cell response for optimal immunity against respiratory Chlamydia pneumoniae infection显示文摘 | Joyee AG Yang X | 2013 | PLo S One2013，8，83： | 1 |
| 16 | Type I IFNs en- hance susceptibility to Chlamydia muridarum lung in- fection by enhancing apoptosis of local macrophages 显示文摘 | QIU H FAN Y JOYEE A G | 2008 | J Immunol2008，181，： | 1 |
| 17 | The Job Satisfaction-Job Performance Relationship:A Qualitative and Quantitative Review显示文摘 | Timothy Judge Carl Thoresen Joyee Bono Gregory Patton | | 0，，： | 1 |
| 18 | Invariant NKT cells preferentially modulate the function of CD8 alpha + den- dritic cell subset in inducing type 1 immunity against in- fection显示文摘 | Joyee A G Uzonna J Yang X | 2010 | J Immunol2010，184，4： | 1 |
| 19 | Extension the sheff life of banana fruit by the 1-MCP in combination with polyethylene bags显示文摘 | Jiang Y M Joyee D C Macnish A J | 1999 | Postharv Biol Technol1999，16，： | 1 |
| 20 | A DNA enzyme with N - glycosylase activity显示文摘 | Sheppard TL Joyee GF | 2000 | Proc Natl Acad Sci USA2000，97，14： | 1 |
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