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| 1 | WJBC 5^(th) Anniversary Special Issues(2): Proteomics In 2014, can we do better than CA125 in the early detection of ovarian cancer?显示文摘Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years with the five-year overall survival remaining between 20% and 40% for stage Ⅲ and Ⅳ disease. In contrast patients with stage Ⅰ disease have a greater than 90% five-year overall survival. Detection of ovarian cancer at an early stage would likely have significant impact on mortality rate. Screening biomarkers discovered at the bench have not translated to success in clinical trials. Existing screening modalities have not demonstrated survival benefit in completed prospective trials. Advances in high throughput screening are making it possible to evaluate the development of ovarian cancer in ways never before imagined. Data in the form of human '-omes' including the proteome, genome, metabolome, and transcriptome are now available in various packaged forms. With the correct pooling of resources including prospective collection of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies. | Joshua G Cohen Matthew White Ana Cruz Robin Farias-Eisner | 2014 | World Journal of Biological Chemistry2014，5，3： | 18 |
| 2 | 应用Models-3/CMAQ研究长三角区域大气污染及输送显示文摘选用美国国家环保局第3代空气质量模式(Models-3,/CMAQ),配合中尺度气象模式(MM5)进行研究,模拟了2001年1、7月份长江三角洲区域冬夏季典型天气条件下大气层二次污染物臭氧及颗粒物的浓度分布及输送状况。采用2001年冬.夏季各10d的小时监测数据对模式验证。结果表明,Models-3/CMAQ对O3、PM10的模拟相关系数分别为0.77和052;一致性指数分别达到081和0.99。模型对于O3略微低估,标准偏差为-31%,而对于PM10则有所高估,标准偏差为46%。对长三角7月份O3浓度及1月份PM10的模拟结果显示,7月份长三角区域16个主要城市O3日均浓度集中在0.043~0.086mg/m^3之间,其中,泰州、扬州.湖州、镇江O3月日均浓度相对较高,均超过0.064mg/m3o模拟时段内O3最高小时浓度达0.276mg/m^3。1月份整个模拟区域PM10月日均浓度为O056mg/m^3,其中,南京市PM10日均浓度最高,达0.080mg/m^3模拟时段内PM10最高小时浓度达0.432mg/m^3研究表明,长三角地区存在明显的污染物输送现象,大气污染已经从局地污染转化为区域污染。 | 李莉 陈长虹 黄海英 黄成 李作攀 Joshua S Fu Carey J Jang David G Streets | 2007 | 上海环境科学2007，26，4： | 11 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 5 | Frequency of esophageal stenosis after simultaneous modulated accelerated radiation therapy and chemotherapy for head and neck cancer 显示文摘 | JOSHUA DL KRISTEN O WILLIAM G | 2008 | American Journal of Otolaryngology2008，29，1： | 1 |
| 6 | Catadioptric stereo using planar mirrors显示文摘 | JOSHUA G SHREE K N | 2001 | International Journal of Computer Vision2001，44，65： | 1 |
| 7 | Therapeutic potentialof mood stabilizers lithium and valproic acid : beyond bipolar disorder显示文摘 | Chi-Tso Chiu Zhifei Wang Joshua G | 2013 | Pharmacol Rev2013，65，1： | 1 |
| 8 | Thermal Conductivity Reduction and Thermoelectric Figure of Merit Increase by Embedding Nan- oparticles in Crystalline Semiconductors 显示文摘 | Woochul K Joshua Z Arthur G | 2006 | Physical Review Letters2006，96，04： | 1 |
| 9 | Control of green and red upconversion in NaYF4:Yb3+,Er3+ nanoparticles by excitation modulation显示文摘 | Gainer C F Joshua G S de Silva C R | | 0，，46： | 1 |
| 10 | Air quality during the 2008 Bering Olympic Games显示文摘 | Streets D G Joshua S F Carey J J | 2007 | Atmospheric Environment2007，41，3： | 1 |
| 11 | 显示文摘 | Joshua P Sade G | 2004 | J Appl Phys2004，91，： | 1 |
| 12 | Inhibition of protein kinase C-beta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans显示文摘 | Joshua A B Allison B G Mary B G | 2002 | Circ Res2002，90，： | 1 |
| 13 | 100 Million-voxel volumetric display 显示文摘 | Favalora G E Napoli Joshua Hall Deirdre M | 2002 | Proceedings of SPIE2002，4712，： | 1 |
| 14 | Diffusion barrier properties of amorphous TiB2 for application in Cu metallization显示文摘 | Pelleg Joshua Sade G | 2002 | J Appl Phys2002，91，9： | 1 |
| 15 | Moisture effect on microbial activity and community structure in decomposing birch litter in the Alaskan taiga显示文摘 | Joshua P S Jay M G Joy S C C etal | 1999 | Soil Biology and Biochemistry1999，31，6： | 1 |
| 16 | Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches显示文摘 | Robert Machold Shigemi Hayashi Michael Rutlin Mandar D Muzumdar Susana Nery Joshua G Corbin Amel Gritli-Linde Tammy Dellovade Jeffery A Porter Lee L Rubin Henryk Dudek Andrew P McMahon Gord Fishell | 2003 | Neuron2003，，1： | 1 |
| 17 | Bio-absorbable soy protein plastic composites:Effect of polyphosphate fillers on biodegradability显示文摘 | ALAN H T JOSHUA U O KAI-LAI G H | 2001 | Journal of Polymers and the Environment2001，，1： | 1 |
| 18 | Allelic variation in the hemolymph juvenile hormonebinding protein gene of Manduca sexta显示文摘 | JOSHUA K YOUNG A WALTER G | 2003 | Molecular and Cellular Endocrinology2003，208，： | 1 |
| 19 | Hyperfunetion- ing intrathyroid parathyroid gland:a potential cause of failure in parathy-roidectomy 显示文摘 | Bahar G Feinmesser R Joshua BZ | 2006 | Surgery2006，139，6： | 1 |
| 20 | Effcient and color -tunable oxyfluoride solid solution phosphors for solid - state white lighting 显示文摘 | Won B I Nathan G Joshua K | 2011 | Adv Mater2011，23，20： | 1 |
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