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| 1 | Evaluation of the string test for the detection of Helicobacter pylori显示文摘AIM: Helicobacter pylori can be diagnosed by invasive ornon-invasive tests but to obtain bacteria for culture andantibiotic susceptibility testing, an upper GI endoscopy isoften required. The string test may be a minimally-invasivealternative method of obtaining H. pylori samples. This studyevaluates the sensitivity and specificity of the string test inthe diagnosis of H. pylori in comparison with endoscopicmeans of diagnosis.METHODS: This was a prospective open comparative studyof patients with dyspepsia with endoscopy-based tests asgold standard (defined as a positive CLO test and antralhistology). Fasting patients swallowed the encapsulated-string(Entero-test Hp), which was withdrawn after 1 hour. Thegastric juice from the string was plated onto H. pylori-selectivemedia for culture. Helicobacter pylori was identified by typicalcolony morphology, gram stain and biochemical test results.RESULTS: Thirty dyspeptic patients were recruited of whom21 (70 %) were positive for H. pylori according to the goldstandard. The sensitivity, specificity, positive predictive value,and negative predictive value for the string test were 38 %,100 %, 100 % and 41% respectively, and for endoscopicbiopsies 81%, 100 %, 100 %, 69 % respectively (P=0.004).Logistic regression showed that only abundant growthdensity from endoscopic biopsy cultures to be a predictor ofa positive string test (P=0.018).CONCLUSION: The string test is an alternative method toendoscopy in obtaining H. pylori but has a low sensitivitycompared to endoscopic biopsies. | Rupert WL Leong Ching C Lee Thomas KW Ling WaiK Leung Joseph JY Sung | 2003 | World Journal of Gastroenterology2003，9，2： | 3 |
| 2 | Development of a novel ERCP mechanical simulator显示文摘 | Joseph WL John GL Micha Rojany | 2007 | Gastrointestinal Endoscopy2007，65，7： | 1 |
| 3 | Surgical resection and adjunctive immunotherapy for selected patients with multiple pumonary metastases显示文摘 | Morton DL Joseph WL Ketcham AS | 1973 | Ann Surg1973，178，： | 1 |
| 4 | The determination of glycogen in liver and muscle by use of anthrone reagent显示文摘 | Robert WL Joseph HR | 1956 | Biochem J1956，59，11： | 1 |
| 5 | A histomorphogenic analysis of bone grafts augmented with adult stem cells显示文摘 | Dennis S Muna S Joseph WL | 2007 | Implant Dent2007，16，1： | 1 |
| 6 | Primary aorto-duodenal fistula:A case report and review of the literature显示文摘 | David WL Joseph DR Carlton M | 2003 | J Vase Stag2003，37，3： | 1 |
| 7 | Molecular structure and function of the glycine receptor chloride channel显示文摘 | Joseph WL | 2004 | Physiol Rev2004，84，4： | 1 |
| 8 | Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate proteomic changes in spinal cord and dorsal root ganglia (DRG) of rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. METHODS: The colonic myeloperoxidase (MPO) activity and tumor necrosis factor-(TNF- ) level were determined. A two-dimensional electrophoresis (2-DE)-based proteomic technique was used to profile the global protein expression changes in the DRG and spinal cord of the rats with acute colitis induced by intracolonic injection of TNBS. RESULTS: TNBS group showed significantly elevated colonic MPO activity and increased TNF-level. The proteins derived from lumbosacral enlargement of the spinal cord and DRG were resolved by 2-DE; and 26 and 19 proteins that displayed significantly different expression levels in the DRG and spinal cord were identified respectively. Altered proteins were found to be involved in a number of biological functions, such as inflammation/immunity, cell signaling, redox regulation, sulfate transport and cellular metabolism. The over-expression of the protein similar to potassium channel tetramerisation domain containing protein 12 (Kctd 12) and low expression of proteasome subunit type-1 (psma) were validated by Western blotting analysis. CONCLUSION: TNBS-induced colitis has a profound impact on protein profiling in the nervous system. This result helps understand the neurological pathogenesis of inflammatory bowel disease. | Xiao-Jun Zhang Feung Ping Leung Wendy WL Hsiao Shun Tan Shao Li Hong-Xi Xu Joseph JY Sung Zhao-Xiang Bian | 2012 | World Journal of Gastroenterology2012，18，23： | 0 |
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