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您的检索式：作者名="Joseph M. Tobin"
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| 1 | Binding of hard and soft metal ions to Rhizopus arrhizus biomass显示文摘 | Joseph M. Brady John M. Tobin | 1995 | Enzyme and Microbial Technology1995，，9： | 1 |
| 2 | Enhancing the dissolution of phenylbutazone using Syloid based mesoporous silicas for oral equine applications显示文摘Three mesoporous silica excipients(Syloid? silicass AL-1 FP, XDP 3050 and XDP 3150) were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although other forms of mesoporous silica have been investigated in previous studies, the effect of inclusion with these specific Syloid? silicas based excipients and more interestingly, with phenylbutazone, is unknown. This work reports a significant enhancement for both the extent and rate of drug release for all three forms of Syloid? silicas at a 1:1 drug:silica ratio over a period of 30 min. An explanation for this increase was determined to be conversion to the amorphous form and an enhanced drug loading ability within the pores. Differences between the release profiles of the three silicas were concluded to be a consequence of the physicochemical differences between the three forms. Overall, this study confirms that Syloid? silicas based excipients can be used to enhance dissolution, and potentially therefore bioavailability, for compounds with poor aqueous solubility such as phenylbutazone. In addition, it has been confirmed that drug release can be carefully tailored based on the choice of Syloid? silicas and desired release profile. | Laura J. Waters John P. Hanrahan Joseph M. Tobin Catherine V. Finch Gareth M.B. Parkes Shamsuddeen A. Ahmad Faraj Mohammad Maria Saleem | 2018 | Journal of Pharmaceutical Analysis2018，8，3： | 1 |
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