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| 1 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 2 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 3 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 4 | Understanding bottom-up continuous hydrothermal synthesis of nanoparticles using empirical measurement and computational simulation显示文摘连续热水的合成为 nanoparticles 的生产作为一种创新技术在最近的评论被加亮。在最近的年里,是大量 nanomaterials 的合成的合适的反应媒介被显示了。许多单个、复杂的 nanomaterials 象金属,金属氧化物,做的氧化物,碳酸盐,硫化物,氢氧化物,磷酸盐,和金属那样器官的框架能用连续热水的合成技术被形成。这个工作介绍方法论试验性地并且数字地描绘连续热水的流动系统,并且为大规模生产决定一个相反当前的 supercritical 水反应堆的可伸缩性(> 1,000 T 敳 ? 潰整瑮慩??? ?? 湯敳 ? 猯'T? 漠 ?? 代嘠愠摮挠瑡污瑹捩挠牵敲瑮搠湥楳祴漠 ????? 湡 ? | Jose Sierra-Pallarest Thomas Huddle Juan Garcia-Serna Esther Alonso Fidel Mato Igor Shvets Olaf Luebben Maria Jose Cocero Edward Lester | 2016 | Nano Research2016，9，11： | 2 |
| 5 | Biomolecular functionalization for enhanced cell–material interactions of poly(methyl methacrylate)surfaces 5th China-Europe Symposium on Biomaterials in Regenerative Medicine(CESB 2015)Hangzhou,China April 7–10,2015显示文摘The integration of implants or medical devices into the body tissues requires of good cell–material interactions.However,most polymeric materials used for these applications lack on biological cues,which enhanced mid-and long-term implant failure due to weak integration with the surrounding tissue.Commonly used strategies for tissue–material integration focus on functionalization of the material surface by means of natural proteins or short peptides.However,the use of these biomolecules involves major drawbacks such as immunogenic problems and oversimplification of the constructs.Here,designed elastin-like recombinamers(ELRs)are used to enhance poly(methyl methacrylate)surface properties and compared against the use of short peptides.In this study,cell response has been analysed for different functionalization conditions in the presence and absence of a competing protein,which interferes on surface–cell interaction by unspecific adsorption on the interface.The study has shown that ELRs can induce higher rates of cell attachment and stronger cell anchorages than short peptides,being a better choice for surface functionalization. | Xavier Punet Rodolphe Mauchauffe´ Jose´C.Rodrı´guez-Cabello Matilde Alonso Elisabeth Engel Miguel A.Mateos-Timoneda | 2015 | Regenerative Biomaterials2015，2，3： | 2 |
| 6 | Enhanced WiFi localization system based on soft computing techniques to deal with small-scale variations in wireless sensors 显示文摘 | Jose M Alonso Manuel Ocana Noelia Hernandez | 2011 | Applied Soft Computing Journal2011，11，8： | 1 |
| 7 | A rapid, direct method for assessing chlorine effect on filamentous bacteria in activated sludge显示文摘 | Goar W Ramirez Jose L Alonso Adelina Villanueva | 2000 | Water Research2000，34，15： | 1 |
| 8 | Immunogenic properties of rabbit haemorrhagic disease virus structural protein VP60 expressed by a recombinat baculovirus: an efficient vaccine显示文摘 | Soledad Marin Jose M Martin Alonso Luis I | 1995 | Virus Research1995，39，： | 1 |
| 9 | Visualization of the African swine fever virus infection in living cells by incorporation into the virus particle of green fluorescent protein-p54 membrane protein chimera显示文摘 | Bruno Hernaez Jose M. Escribano Covadonga Alonso | 2006 | Virology2006，，1： | 1 |
| 10 | Leishmania infantum: Gene Cloning of the GRP94 Homologue, Its Expression as Recombinant Protein, and Analysis of Antigenicity显示文摘 | Ruth Larreta Manuel Soto Carlos Alonso Jose M. Requena | 2000 | Experimental Parasitology2000，，2： | 1 |
| 11 | Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation 显示文摘 | Jose Rodrigo David Alonso Ana Patricia Fernandez | 2001 | Brain Res2001，909，12： | 1 |
| 12 | 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture显示文摘 | Carlos Guijarro Luis Miguel Blanco-Colio Monica Ortego Covadonga Alonso Alberto Ortiz Juan Jose Plaza Cristina Diaz Gonzalo Hernandez Jesus Egido | 1998 | Circulation Research1998，，5： | 1 |
| 13 | Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles显示文摘 | Rocío Fernández-Urrusuno Pilar Calvo Carmen Remu?án-López Jose Luis Vila-Jato María José Alonso | 1999 | Pharmaceutical Research1999，，10： | 1 |
| 14 | Enhanced WiF i localization system based on Soft Computing techniques to deal with small-scale variations in wireless sensors显示文摘 | Jose M Alonso Manuel Ocana Noelia Hernandez | 2011 | Applied Soft Computing2011，，11： | 1 |
| 15 | Optical Encoder Based on the Lau Effect 显示文摘 | DANIEL CRESPO JOSE'ALONSO TOMA'S MORLANES | 2000 | Society of Photo-Optical Instrumentation Engineers2000，39，3： | 1 |
| 16 | Simulation model of an indirect evaporative cooler 显示文摘 | J F SAN JOSE ALONSO | 1998 | Energy and Buildings1998，，29： | 1 |
| 17 | Arabidopsis RIN4 Is a Target of the Type III Virulence Effector AvrRpt2 and Modulates RPS2-Mediated Resistance显示文摘 | David Mackey Youssef Belkhadir Jose M. Alonso Joseph R. Ecker Jeffery L. Dangl | 2003 | Cell2003，，3： | 1 |
| 18 | Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines显示文摘 | Pilar Calvo Carmen Remu?an-López Jose Luis Vila-Jato María José Alonso | 1997 | Pharmaceutical Research1997，，10： | 1 |
| 19 | Prepartion and in vitro evaluation of chitosan nanoparticles containing a caspase inhibitor显示文摘 | Yesim Aktas Karine Andrieux Maria Jose Alonso | 2005 | Int J Phann2005，298，： | 1 |
| 20 | Systematic method for the exact synthesis of ultra-wideband filtering responses using high-pass and low-pass sections 显示文摘 | ROBERTO G JOSE I ALONSO | 2006 | IEEE Transactions on Microwave Theory and Techniques2006，54，10： | 1 |
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