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| 1 | Incidence and risk factors for early renal dysfunction after liver transplantation显示文摘AIM: To determine renal dysfunction post liver transplantation, its incidence and risk factors in patients from a Belgian University Hospital.METHODS: Orthotopic liver transplantations performed from January 2006 until September 2012 were retrospectively reviewed(n = 187). Patients with no renal replacement therapy(RRT) before transplantation were classified into four groups according to their highest creatinine plasma level during the first postoperative week. The first group had a peak creatinine level below 12 mg/L, the second group between 12 and 20 mg/L, the third group between 20 and 35 mg/L, and the fourth above 35 mg/L. In addition, patients who needed RRT during the first week after transplantation were also classified into the fourth group. Perioperative parameters were recorded as risk factors, namely age, sex, bodymass index(BMI), length of preoperative hospital stay, prior bacterial infection within one month, preoperative ascites, preoperative treatment with β-blocker, angiotensin-converting enzyme inhibitor or non steroidal anti-inflammatory drugs, preoperative creatinine and bilirubin levels, donor status(cardiac death or brain death), postoperative lactate level, need for intraoperative vasopressive drugs, surgical revision, mechanical ventilation for more than 24 h, postoperative bilirubin and transaminase peak levels, postoperative hemoglobin level, amount of perioperative blood transfusions and type of immunosuppression. Univariate and multivariate analysis were performed using logistic ordinal regression method. Post hoc analysis of the hemostatic agent used was also done.RESULTS: There were 78 patients in group 1(41.7%), 46 in group 2(24.6%), 38 in group 3(20.3%) and 25 in group 4(13.4%). Twenty patients required RRT: 13(7%) during the first week after transplantation. Using univariate analysis, the severity of renal dysfunction was correlated with presence of ascites and prior bacterial infection, preoperative bilirubin, urea and creatinine level, need for surgical revision, use of vasopressor, postoperative mechanical ventilation, postoperative bilirubin and urea, aspartate aminotransferase(ASAT), and hemoglobin levels and the need for transfusion. The multivariate analysis showed that BMI(OR = 1.1, P = 0.004), preoperative creatinine level(OR = 11.1, P < 0.0001), use of vasopressor(OR = 3.31, P = 0.0002), maximal postoperative bilirubin level(OR = 1.44, P = 0.044) and minimal postoperative hemoglobin level(OR = 0.059, P = 0.0005) were independent predictors of early post-liver transplantation renal dysfunction. Neither donor status nor ASAT levels had significant impact on early postoperative renal dysfunction in multivariate analysis. Absence of renal dysfunction(group 1) was also predicted by the intraoperative hemostatic agent used, independently of the extent of bleeding and of the preoperative creatinine level.CONCLUSION: More than half of receivers experienced some degree of early renal dysfunction after liver transplantation. Main predictors were preoperative renal dysfunction, postoperative anemia and vasopressor requirement. | Patricia Wiesen Paul B Massion Jean Joris Olivier Detry Pierre Damas | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Exploiting Intrinsic Nanoparticle Toxicity:The Pros and Cons of Nanoparticle- Induced Autophagy in Biomedical Research显示文摘 | Peynshaert K Manshian B B Joris F | 2014 | Chem Rev2014，114，15： | 1 |
| 3 | Characteristics and applications of fast-wave gyrodevices显示文摘 | Felch K L Danly B G Jory H R | 1999 | Proc of the IEEE1999，87，5： | 1 |
| 4 | Determinants of symptom severity and weight loss in functional dyspepsia显示文摘 | Van Oudenhove L Joris V Geeraerts B | 2008 | Gut2008，57，12： | 1 |
| 5 | Bacterialpepfidoglycan (murein) hydrolases 显示文摘 | VOLLMER W JORIS B CHARLIER P | 2008 | FEMS Microbiology Reviews2008，32，： | 1 |
| 6 | Intimate justice: Confronting issues of accountability, respect, and freedom in treatment for abuse and violence 显示文摘 | Jory B Anderson D G-reer C | 1997 | J Marital Fam Ther1997，23，4： | 1 |
| 7 | Determinants of symptom severity and weight loss in functional dyspepsia显示文摘 | Van Oudenhove L Joris V Geeraerts B | 2006 | Gastroenterology2006，130，42： | 1 |
| 8 | Determinants of symptom severity and weight loss in functional dyspepsia显示文摘 | Van Oudenhove L Joris V Geeraerts B | 2006 | Gastroenterology2006，130，42： | 1 |
| 9 | Method for estimation of low outer membrane permeability to β-lactam antibiotics 显示文摘 | Lakaye B Dubus A Joris B | 2002 | Antimicrob Agents Chemother2002，46，9： | 1 |
| 10 | The diversity structure and regulation of beta-lactamases显示文摘 | Philippon A Dusart J Joris B | 1998 | Cell Mol Life Sci1998，54，6： | 1 |
| 11 | Quantitative relationship between sensitivity to β-laetam antibiotics and β-laetamaees production gram-negative bacteria-Ⅱ non-steadstate treatment and progress curves显示文摘 | Frere JM Joris B | 1989 | Biochem Pharmacol1989，38，： | 1 |
| 12 | Investigation of impact stress induced in laboratory dynamic compaction of sift int显示文摘 | Thilakasiri H S Gunaratne M Mullins G Stinnette P Jory B | 1996 | Numer Anal methods geomech1996，20，10： | 1 |
| 13 | Determinants of symptom severity and weight loss in functional dyspepsia 显示文摘 | Van Ouderhove L Joris V Geerates B | 2006 | Gastroenterology2006，130，2： | 1 |
| 14 | Modification of polymer light emission by lateral microstructure 显示文摘 | Safonov A N Jory M Matterson B K | 2001 | Synthetic Metals2001，116，： | 1 |
| 15 | Modification of polymer light emission by lateral microstructure显示文摘 | Safonov A N Jory M Matterson B J | 2001 | Synthetic Metals2001，116，1： | 1 |
| 16 | The diversity, structure and regulation of beta - 1actamases 显示文摘 | Phrlippon A Dusart J Joris B | 1998 | Cell Mol Life Sci1998，54，4： | 1 |
| 17 | Determinants of symptoms severity and Weightloss infunctional dyspepsia 显示文摘 | Van Oudenhove L Joris V Geeraerts B | 2006 | Gastroen terology2006，130，42： | 1 |
| 18 | Characteristics and Application of fast-Wavegyrodevices 显示文摘 | Felch K L Danly B G Jory H R etal | 1999 | Porc IEEE1999，87，5： | 1 |
| 19 | Su-35s to have Over the Shoulder' ability 显示文摘 | CHARLES B JORIS J L PAUL B | 1993 | JDW1993，，2： | 1 |
| 20 | Determinants of symp- tom severity and weight loss in functional dyspensia显示文摘 | Van Ouderhove L Joris V Geeraerts B | 2006 | Gastroenter- ology2006，130，2： | 1 |
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