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| 1 | Non-pharmacological cognitive intervention for aging and dementia:Current perspectives显示文摘In recent years, cognitive difficulties associated with normal aging and dementia have been receiving increased attention from both public and scientific communities. With an increase in overall lifespan, promoting healthy cognition has become a priority and a necessity for minimizing and preventing individual and societal burdens associated with cognitive dysfunctions in the elderly. The general awareness concerning the efficacy of preventive(e.g., lifestyles) and palliative treatment strategies of cognitive impairments, related to either healthy or unhealthy trajectories in cognitive aging, is continuously rising. There are several therapeutic strategies which can be broadly classified as either pharmacological or non-pharmacological/psychosocial. In face of the modest evidence for success of pharmacological treatments, especially for dementia related impairments, psychosocial interventions are progressively considered as a complementary treatment. Despite the relative spread of psychosocial interventions in clinical settings, research in this area is rather scarce with evidence for success of these therapies remaining controversial. In this work we provide an evidence based perspective on cognitive intervention(s) for healthy aging, pre-dementia(mild cognitive impairment), and dementia populations. Current evidence and future directions for improving cognitive functions in the elderly are discussed as well. | Jorge Alves Rosana Magalh?es álvaro Machado óscar F Gon?alves Adriana Sampaio Agavni Petrosyan | 2013 | World Journal of Clinical Cases2013，1，8： | 8 |
| 2 | Diagnosis and Objective Pain Assessment of Traditional Chinese Medicine May Be Useful to Demonstrate Specific Effects of Acupuncture in Low Back Pain: A Prospective, Randomized, Controlled and Single Blinded Pre-study显示文摘Objective: To prove specific effects of acupuncture on chronic pain. It was speculated that the potential specific effectiveness of acupuncture could be better shown in more properly designed studies. Therefore, diagnoses of both Western medicine and traditional Chinese medicine (TCM) were used as inclusion criteria to allocate acupoints more precisely to the complaints of the patients. Secondly, objectively measurable parameters of pain relief in addition to usual Visual Analogue Scale (VAS) were chosen to quantify the effects of acupuncture. Methods: The study was prospective, randomized, controlled and single-blinded. Eighteen patients with chronic back pain and TCM diagnosis of a Taiyang/Yangming syndrome received one single session of acupuncture chosen according to TCM diagnosis or acupuncture on points outside the meridian system (controls). We evaluated pain via VAS and increased mobility via inclinometry of the back. Results: Although the sample size was small, there was a statistically significant improvement in pain and mobility in the intervention group (n=13), but not in the control group (n=5). The calculated sample size adequate power was lower for inclinometry than for VAS, indicating that VAS is less probable to discriminate acupuncture effects. Conclusion: Objectively measurable physical parameters such as the angle of flexion before and after acupuncture (inclinometry) may be more suitable to measure pain relief than subjective assessment by VAS in acupuncture studies. TCM diagnosis may be a helpful inclusion criterion in studies on acupuncture, so as to potentially allocate interventions better to the complaints of patients. | Susana Seca Paula Capelo Thomas Efferth Christoph Alexander Doenitz Sven Schroeder Ana Anjos Jorge Machado Henry Johannes Greten | 2013 | Journal of Acupuncture and Tuina Science2013，11，3： | 2 |
| 3 | 氮素改变辣椒初级代谢和薄壁组织厚度调控比叶面积研究显示文摘比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinense)SLA的影响,研究对两个中国辣椒商品种(Biquinho和Habanero)的初级代谢产物和形态特征进行了分析。两种基因型辣椒的SLA随着遮阴而增加,但随氮供应量的增加而下降;在氮素供应由缺乏到充足的范围内Habanero品种的SLA表现稳定。相关分析表明,高氮供应导致SLA降低是因为氨基酸、蛋白质和淀粉含量的调节,从而影响叶片密度。此外,在中度缺氮到充足供氮范围内,两种基因型辣椒的SLA表现出响应差异,Biquinho和Habanero分别在栅栏和海绵状薄壁组织上表现出差异。总之,结果表明,SLA对氮供应的反应是由某些代谢物含量和依赖于基因型的影响叶片厚度及密度的薄壁组织变化平衡调节的。 | Lucas de ávila Silva Rebeca P.Omena-Garcia Jorge A.Condori-Apfata Paulo Mafra de Almeida Costa Natália Machado Silva Fábio M.Da Matta Agustin Zsogon Wagner L.Araújo Edgard A.de Toledo Picoli Ronan Sulpice Adriano Nunes-Nesi 沈凌峰 吉雪花(译) | 2021 | 辣椒杂志2021，，3： | 2 |
| 4 | Rheological behavior of compatibilized and non-compatibilized PA6/EPM blends显示文摘 | Jorge Silva Ana Vera Machado Jo?o Maia | 2007 | Rheologica Acta2007，，8： | 1 |
| 5 | Rheologi-cal behavior of compatibilized and non-compatibilizedPA6/EPM blends显示文摘 | Jorge Silva Ana Vera Machado Joao Maia | 2007 | Rheol Acta2007，46，8： | 1 |
| 6 | 气功对学习横笛儿童焦虑和心理应激功能的影响(英文)显示文摘目的:基于病例治疗,对气功疗效是否可以用生理测量指标和心理评分量化这一命题进行研究。方法:研究设计为前瞻性干预对照研究。气功组纳入8名儿童,接受为期7周的'白球'气功训练,每周2次,每次30min。对照组纳入8名儿童不接受气功训练。使用针对儿童的'抑郁、焦虑和压力量表'衡量焦虑的主观感受。此外,在研究开始和结束时分别测量两组儿童的唾液中皮质醇水平、心率变化、血压、斜方肌肌电图、反应时间等指标。结果:与对照组比较,气功组在心率指标方面显著降低。虽然在其他指标方面两组之间无显著差异,但是气功组在唾液中皮质醇水平、斜方肌肌电图及血压等指标方面的效应量更大。在焦虑主观感受、唾液中皮质醇水平和心率指标方面,气功组相对较低。结论:'白球'气功可以显著降低学习乐器表演的儿童的心率。基于本研究8/8的样本量,气功也有减轻焦虑和降低血压的作用。对于今后将要开展的量化气功疗效的研究,可以增大样本量,研究其他焦虑感增加的环境下年轻人的情况,设置合理的对照干预措施,解决设盲的问题,测量其他可能会受到气功治疗影响的指标,以及比较气功与其他可以降低焦虑的方法的疗效。 | Claudia Maria Sousa Mario Gonalves Jorge Machado Thomas Efferth Tobias Greten Petra Froeschen Henry J. Greten | 2012 | 中西医结合学报2012，10，8： | 1 |
| 7 | Mycorrhizal synthesis between Pisolithus arhizus and adult clones of Arbutus unedo in vitro and in nursery显示文摘Arbutoid mycorrhizae were synthesized between adult selected clones of Arbutus unedo L.and Pisolithus arhizus.Two micropropagated clones were tested: AL1, in vitro and C1(acclimatized plants)in nursery and later in a field trial.In vitro, rooted shoots were transferred to test tubes containing the substrate previously inoculated with mycelium cultured on agar.In the nursery, two inoculation treatments were tested(vegetative inocula or dry sporocarps) and compared to control plants.In the field trial, plants from nursery inoculation treatments were compared and an additional control treatment using seedlings was implemented.Plant height was evaluated 4 months later in the nursery and 20 months later in the field trial.Roots were examined by morphological and histological studies: a) in vitro plantlets one month after inoculation and nine months after acclimatization; and b) 20 months after the field trial was established.Arbutoid mycorrhizae were observed in vitro one month after inoculation, indicating compatibility between A.unedo and P.arhizus.These showed the presence of a mantle, Hartig net,and intracellular hyphal complexes confined to the epidermal root cells.Arbutoid mycorrhizae were also observed nine months after acclimatization in inoculated and control plants.In order to confirm the identity of mycorrhizae, molecular techniques were used, in previously inoculated in vitro plants, 12 months after acclimatization.Thelephora and Hebeloma mycorrhizae, two types of highly competitive and widespread mycorrhizae on nurseries were identified.In the nursery, dry sporocarp treatment improved plant height after four months.In a field trial(20months later), plants growth did not show significant differences.By this time, mycorrhized roots with Cenococcum geophilum and other types were identified.These results and their implications on A.unedo breeding program are discussed. | Filomena Gomes Helena Machado Esteban San Martin A.Portugal Jorge M.Canhoto | 2013 | Journal of Forestry Research2013，24，4： | 1 |
| 8 | Superficial EWSR1 -negative undifferentiated small round cell sarcoma with CIC/ DUX4 gene fusion: a new variant of Ewing-like tumors with locoregional lymph node metastasis显示文摘 | Isidro Machado Julia Cruz Javier Lavernia Luis Rubio Jorge Campos María Barrios Camille Grison Virginie Chene Gaelle Pierron Olivier Delattre Antonio Llombart-Bosch | 2013 | Virchows Archiv2013，，6： | 1 |
| 9 | 显示文摘 | Machado R Kasama A H Jorge A M | 2007 | Mat Sci Eng a-Struct2007，449，： | 1 |
| 10 | Treatment of acid mining waters显示文摘 | S Santos R Machado M Joana Neiva Correia Jorge R Carvalho | 2003 | Minerals Engineering2003，，2： | 1 |
| 11 | The experience of the family caregiver of stroke victim显示文摘 | Machado AL Jorge MS Freitas CH | 2009 | Rev Bras Enferm2009，62，2： | 1 |
| 12 | Treatment of acid mining waters显示文摘 | S Santos R Machado M Joana Neiva Correia Jorge R Carvalho | 2003 | Minerals Engineering2003，，2： | 1 |
| 13 | Cytotoxicity of denture base acrylic resins: A literature review 显示文摘 | Jorge Jl-l Giampaolo ET Machado AL | 2003 | J Prosthet Dent2003，90，2： | 1 |
| 14 | 关于数据战略,管理层应思考四个问题显示文摘亚马逊创始人兼CEO杰夫·贝索斯曾在致股东信中评论了数据、数据库和机器学习。我们把这封信视为一个“号召”,表明数据和数据管理能力将是未来几年大多数企业成功的关键,我们认为:数据和数据管理能力将成为各类公司之间的关键差距。数据技术提供商将大幅提升数据和分析工具的可用性,降低其成本。对于任何企业来说,人工智能、机器学习和其他强大的工具都将成为其筹码。根据具体数据定制的方案会激增.通用方法将丧失竞争力。 | Antonio Castro Tony Ho Jorge Machado Allen Weinberg | 2020 | 销售与管理2020，0，1： | 0 |
| 15 | Effects of self-administered exercises based on Tuina techniques on musculoskeletal disorders of professional orchestra musicians: a randomized controlled trial显示文摘BACKGROUND: Musicians are frequently affected by playing-related musculoskeletal disorders(PRMD). Common solutions used by Western medicine to treat musculoskeletal pain include rehabilitation programs and drugs, but their results are sometimes disappointing.OBJECTIVE: To study the effects of self-administered exercises based on Tuina techniques on the pain intensity caused by PRMD of professional orchestra musicians, using numeric visual scale(NVS). DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: We performed a prospective, controlled, single-blinded, randomized study with musicians suffering from PRMD. Participating musicians were randomly distributed into the experimental(n = 39) and the control(n = 30) groups. After an individual diagnostic assessment, specific Tuina self-administered exercises were developed and taught to the participants. Musicians were instructed to repeat the exercises every day for 3 weeks. MAIN OUTCOME MEASURES: Pain intensity was measured by NVS before the intervention and after 1, 3, 5, 10, 15 and 20 d of treatment. The procedure was the same for the control group, however the Tuina exercises were executed in points away from the commonly-used acupuncture points. RESULTS: In the treatment group, but not the control group, pain intensity was significantly reduced on days 1, 3, 5, 10, 15 and 20.CONCLUSION: The results obtained are consistent with the hypothesis that self-administered exercises based on Tuina techniques could help professional musicians controlling the pain caused by PRMD. Although our results are very promising, further studies are needed employing a larger sample size and double blinding designs. | Cláudia Maria Sousa Daniela Coimbra Jorge Machado Henry J.Greten | 2015 | Journal of Integrative Medicine2015，13，5： | 0 |
| 16 | Reviving Direct Observation Methods for Physical Activity Behavior显示文摘Purpose:Current Direct Observation(DO)methods are burdensome to the observer and relevant limitations can be identified on the outcome information.This study aims to characterize DO from the observers’point of view and to analyze the feasibility and usefulness of visual information in the form of video.Method:data collection was done with ten adult males,observed while performing different physical activities in an indoor court.Sessions were video recorded by two cameras.Three observers performed systematic observation,using SOPLAY,with different sampling rates.Inter observer’s agreement and with reference data was analyzed by Cohen’s Kappa statistic.Results:SOPLAY highest agreement between observers was 0.611 on vigorous category and walking category had the lowest 0.188.It doubles the time needed to annotate the video with pauses,but half of player’s behavior is preserved.Conclusion(s):using video to support DO permits to collect more accurate data and a more detailed behavior categorization is warranted.Developments in computer vision are expected to reduce the human efforts in DO methods. | Pedro Miguel Ribeiro da Silva Sérgio Hélder da Silva Soares Soares Jorge Augusto Pinto Silva Mota Paula Maria Marques Moura Gomes Viana Pedro Miguel Machado Soares Carvalho | 2021 | Journal of Sports Science2021，9，1： | 0 |
| 17 | Influence of Testing Temperature on the Corrosion Behavior of API 5L X70 Pipeline Steel显示文摘 | Carlos Antonio Vieira de Almeida Machado Renato Altobelli Antunes Elisabete Jorge Pessine Olandir Vercino Correa | 2014 | Journal of Mechanics Engineering and Automation2014，4，6： | 0 |
| 18 | Immediate effects of Tuina techniques on working-related musculoskeletal disorder of professional orchestra musicians显示文摘BACKGROUND:Musicians are a prone group to suffer from working-related musculoskeletal disorder(WRMD).Conventional solutions to control musculoskeletal pain include pharmacological treatment and rehabilitation programs but their effi ciency is sometimes disappointing.OBJECTIVE:The aim of this research is to study the immediate effects of Tuina techniques on WRMD of professional orchestra musicians from the north of Portugal.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:We performed a prospective,controlled,single-blinded,randomized study.Professional orchestra musicians with a diagnosis of WRMD were randomly distributed into the experimental group(n=39)and the control group(n=30).During an individual interview,Chinese diagnosis took place and treatment points were chosen.Real acupoints were treated by Tuina techniques into the experimental group and non-specifi c skin points were treated into the control group.Pain was measured by verbal numerical scale before and immediately after intervention.RESULTS:After one treatment session,pain was reduced in 91.8%of the cases for the experimental group and 7.9%for the control group.CONCLUSION:Although results showed that Tuina techniques are effectively reducing WRMD in professional orchestra musicians of the north of Portugal,further investigations with stronger measurements,double-blinding designs and bigger simple sizes are needed. | Cláudia Maria Sousa Luis Moreira Daniela Coimbra Jorge Machado Henry J.Greten | 2015 | Journal of Integrative Medicine2015，13，4： | 0 |
| 19 | Assessment of Short-term Acupuncture Effect Through Electro-conductivity Variation of Yuan-Source Acupoints显示文摘Objective: To demonstrate that acupuncture has an instant effect in equilibrating the imbalanced electrical conductivity of Yuan-Source acupoints after intervention on the Luo-Connecting acupoint(one-side) of the same channel.Methods: The experiment was designed as a randomized blinded control trial, with 56 volunteers. Reactive Electrical Permeable Points(REPP-mostly Yuan points) were measured in terms of electrical conductivity. Patients with a split-meridian(difference between left and right measurement) were randomly included in the control or experimental group. After five minutes of needle insertion in a Luo acupoint, the needle was removed and REPP were re-measured twice within a five minutes interval.Results: From the 56 volunteers, 32 had a valid Split-Meridian Difference(SMD > 20 μA) and were included in the study. The results indicate that after the third measurement(15 minutes-M3), 100% of the experimental group had SMD < 20 μA and 55% was with a SMD = 0 μA. In contrast, for the control group, 92% remained with a SMD >20 μA, at M3, when compared with the initial measurement(M1). Results obtained between the experimental and control group are significantly different(p< 0.001).Conclusions: The present exploratory work indicates that there is evidence of instant body response to acupuncture that can be detected by changes in the electro-conductivity of specific acupoints. | Daniel Cerqueira Ribeiro André António Moura dos Santos Rui Pedro Loureiro Rui Miguel Gonalves Jorge Pereira Machado | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
| 20 | Leukocytoclastic vasculitis caused by hepatitis C virus in a liver transplant recipient: A case report显示文摘BACKGROUND Infection by the hepatitis C virus(HCV) is currently considered to be a global health issue, with a high worldwide prevalence and causing chronic disease in afflicted individuals. The disease largely involves the liver but it can affect other organs, including the skin. While leukocytoclastic vasculitis has been reported as one of the dermatologic manifestations of HCV infection, there are no reports of this condition as the first symptom of HCV recurrence after liver transplantation.CASE SUMMARY We report here a case of leukocytoclastic vasculitis in a liver transplant recipient on maintenance immunosuppression. The condition presented as a palpable purpura in both lower extremities. Blood and urine cultures were negative and all biochemical tests were normal, excepting evidence of anemia and hypocomplementemia. Imaging examination by computed tomography showed a small volume of ascites, diffuse thickening of bowel walls, and a small bilateral pleural effusion. Skin biopsy showed leukocytoclasia and fibrinoid necrosis.Liver biopsy was suggestive of HCV recurrence in the graft, and HCV polymerase chain reaction yielded 11460 copies/mL and identified the genotype as 1 A. Treatment of the virus with a 12-wk direct-acting antiviral regimen of ribavirin, sofosbuvir and daclatasvir led to regression of the symptoms within the first 10 d and subsequent complete resolution of the symptoms.CONCLUSION This case highlights the difficulties of diagnosing skin lesions caused by HCVinfection in immunosuppressed patients. | Gustavo de Sousa Arantes Ferreira Andre Luis Conde Watanabe Natalia de Carvalho Trevizoli Fernando Marcus Felippe Jorge Luiz Gustavo Guedes Diaz Milla Carolina Costa Lafeta Araujo Gabriela de Campos Araujo Amanda de Castro Machado | 2019 | World Journal of Hepatology2019，11，4： | 0 |
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