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| 1 | Aging and menopause reprogram osteoclast precursors for aggressive bone resorption显示文摘Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing osteoporosis.The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes.However,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity.Therefore,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were collected.Using multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with age.We conclude that monocytes are'reprogrammed'in vivo,allowing them to'remember'age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive osteoclasts.Our discovery suggests that this may be mediated through DNA methylation.We suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss. | Anais Marie Julie Moller Jean-Marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe | 2020 | Bone Research2020，8，3： | 4 |
| 2 | Novel functions of vimentin in cell adhesion, migration and signaling 显示文摘 | Johanna I Hanna-Mari P Jonna N | 2007 | Experimental Cell Research2007，10，313： | 1 |
| 3 | Novel functions of vimentin in cell adhesion, migration, and signaling显示文摘 | Johanna Ivaska Hanna-Mari Pallari Jonna Nevo John E. Eriksson | 2007 | Experimental Cell Research2007，，10： | 1 |
| 4 | Perioperative pain, psy- chological distress, and immune function in men undergoing pros- tatectomy for cancer of the prostate显示文摘 | Yermal SJ Linda WJ Jonna P etal | 2010 | Biological Research for Nursing2010，11，4： | 1 |
| 5 | Xylanases in bleaching: from an idea to the industry 显示文摘 | Liisa Viikari Anne Kantelinen Jonna Sundquist | 1994 | FEMS Microbiology1994，13，2： | 1 |
| 6 | Novel function of vimentin in cell adhesion, migration and signaling显示文摘 | Johanna I Hanna-Mari P Jonna N | 2007 | Experimental Cell Research2007，10，313： | 1 |
| 7 | 14-3-3^as a predictor of early time to recurrence and distant metastasisin hormone receptor-positive and -negative breast cancers 显示文摘 | Anna Bergamaschi Jonna Frasor Kristina Borgen | 2013 | Breast Cancer Res Treat2013，137，3： | 1 |
| 8 | The English Language Teacher's Handbank,How to teach large classes with few resourses显示文摘 | Jonna Baker Heather Westrup | | 0，，： | 1 |
| 9 | How consumers with disabilities perceive 'welcome' in retail servicescapes: a critical incident study显示文摘 | Baker S M Jonna H Carol K-S | 2007 | Journal of Services Marketing2007，21，3： | 1 |
| 10 | Customer Participation in Creating Site Brand Loyalty 显示文摘 | Jonna Holland Stacey Menzel Baker | 2001 | Journal of Interactive Marketing2001，15，4： | 1 |
| 11 | Nitrogen removal from wastewater with high ammonia nitrogen concention via shorter nitrification and denitrification显示文摘 | Jonna S G Andrzej C Korneliusz M | 1997 | Water Sci Technol1997，36，10： | 1 |
| 12 | Prolonged simulated acid rain and heavy metal deposition: separated and combined effects on forest soil microbial community structure 显示文摘 | Taina Pennanen Jonna Perkiomaki Oili Kiikkila | 1998 | FEMS Microbiology Ecology1998，27，： | 1 |
| 13 | Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) a or ERβ in human osteosarcoma cells : distinct and common target genes for there receptors显示文摘 | Fabio S Daniel H B Jonna F | 2004 | Endocrinology2004，145，7： | 1 |
| 14 | Nucleation mode particles with a nonvolatile core in the exhaust of a heavy duty diesel vehicle显示文摘 | Topi R6nkk6 Annele Virtanen Jonna Kannosto | 2007 | Envi- ron Sci Technol2007，41，18： | 1 |
| 15 | Processing and properties of cryogenically milled post consumer mixed plastic waste 显示文摘 | Srinivas Jonna Jed Lyons | 2005 | Polymer Testing2005，24，4： | 1 |
| 16 | Bioleaching in brackish waters-effect of chloride ions on the acidophile population and proteomes of model species显示文摘 | Carla M Zammit Stefanie Mangold Venkateswara Rao Jonna | 2012 | Appl Microbiol Biotechnol2012，93，： | 1 |
| 17 | Tuomas Eerola:Who Enjoys Liste ning to Sad Music and Why显示文摘 | Jonna K. Vuoskoski William F. Thompson Doris McIlwain | | 0，，： | 1 |
| 18 | Middle school student perceptions of school climate: Examining protective functions on subsequent adjustment problems显示文摘 | Alexandra Loukas Jonna L. Murphy | 2006 | Journal of School Psychology2006，，3： | 1 |
| 19 | Iron homeostasis and responses to iron limitation in extreme acidophiles from the Ferroplasma genus显示文摘 | Potrykus J Jonna VR Dopson M | 2011 | Proteomics2011，11，1： | 1 |
| 20 | Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells显示文摘 | Deshanie Rai Antonina Frolova Jonna Frasor | 2005 | Mol Endocrinol2005，19，12： | 1 |
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