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您的检索式：作者名="Jonathan Garnier"
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| 1 | Organ sparing to cure stage IV rectal cancer: A case report and review of literature显示文摘BACKGROUND Rectal sparing is an option for some rectal cancers with complete or good response after chemoradiotherapy(CRT);however,it has never been evaluated in patients with metastases.We assessed long-term outcomes of a rectal-sparing approach in a liver-first strategy for patients with rectal cancer with resectable liver metastases.CASE SUMMARY We examined patients who underwent an organ-sparing approach for rectal cancer with synchronous liver metastases using a liver-first strategy during 2010-2015(n=8).Patients received primary chemotherapy and pelvic CRT.Liver surgery was performed during the interval between CRT completion and rectal tumor re-evaluation.Clinical and oncological characteristics and long-term outcomes were assessed.CASE SUMMARY All patients underwent liver metastatic resection with curative intent.The R0 rate was 100%.Six and two patients underwent local excision and a watch-and-wait(WW)approach,respectively.All patients had T3N1 tumors at diagnosis and had good clinical response after CRT.The median survival time was 60(range,14-127)mo.Three patients were disease free for 5,8,and 10 years after the procedure.Five patients developed metastatic recurrence in the liver(n=5)and/or lungs(n=2).Only one patient developed local recurrence concurrent with metastatic recurrence 24 mo after the WW approach.Two patients died during follow-up.CONCLUSION The results suggest good local control in patients undergoing organ-sparing strategies for rectal cancer with synchronous liver metastasis.Prospective trials are required to validate these data and identify good candidates for these strategies. | Hélène Meillat Jonathan Garnier Anais Palen Jacques Ewald Cécile de Chaisemartin Marguerite Tyran Emmanuel Mitry Bernard Lelong | 2023 | World Journal of Gastrointestinal Surgery2023，15，11： | 0 |
| 2 | Interaction between a diesel-fuel spray and entrained air with single- and double-injection strategies using large eddy simulations显示文摘Interaction between fuel and air in a combustion chamber is one of the main drivers of the mixing process.Experimentally,flow visualizations are limited by high droplet density in the spray.Numerically,the ability of large eddy simulations(LES)to resolve large scales of flow offers good perspectives on capturing flow structures issued from the interaction between the Lagrangian(fuel droplets)and Eulerian(ambient gas)phases.This study examined these interactions first during a single injection using 3D and 2D criteria for both phases.As for the 3D criteria,the spray shape was analyzed in parallel to the Q-criteria applied to the Eulerian phase,making it possible to relate the spray deformations to some specific Eulerian structures.Secondly,2D criteria were the fuel mass-fraction field and Eulerian streamlines,both taken in the mid-plane of the spray.This last analysis allows for identifying certain mechanisms involved in the Eulerian phase’s structure generation and relates it to high fuel-concentration areas in the fuel mass-fraction visualizations. | Jonathan Brulatout François Garnier Patrice Seers | 2020 | Propulsion and Power Research2020，9，1： | 0 |
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