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| 1 | Validation and Implementation of Targeted Capture and Sequencing for the Detection of Actionable Mutation, Copy Number Variation, and Gene Rearrangement in Clinical Cancer Specimens显示文摘 | Colin C. Pritchard Stephen J. Salipante Karen Koehler Christina Smith Sheena Scroggins Brent Wood David Wu Ming K. Lee Suzanne Dintzis Andrew Adey Yajuan Liu Keith D. Eaton Renato Martins Kari Stricker Kim A. Margolin Noah Hoffman Jane E. Churpek Jonathan | 2014 | The Journal of Molecular Diagnostics2014，，1： | 1 |
| 2 | Comprehensive neurocognitive assessment of patients with anorexia nervosa显示文摘AIM:To utilise a comprehensive cognitive battery to gain a better understanding of cognitive performance in anorexia nervosa(AN).METHODS:Twenty-six individuals with AN and 27 healthy control participants matched for age,gender and premorbid intelligence,participated in the study.A standard cognitive battery,the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery,was used to investigate performance on seven cognitive domains with the use of 10 different tasks:speed of processing[Brief Assessment Of Cognition In Schizophrenia:Symbol Coding,Category Fluency:Animal Naming(Fluency)and Trail Making Test:Part A],attention/vigilance[Continuous Performance Test-Identical Pairs(CPT-IP)],working memory[Wechsler Memory Scale(WMS?-Ⅲ):Spatial Span,and Letter-Number Span(LNS)],verbal learning[Hopkins Verbal Learning Test-Revised],visual learning[Brief Visuospatial Memory Test-Revised],reasoning and problem solving[Neuropsychological Assessment Battery:Mazes],and social cognition[Mayer-Salovey-Caruso Emotional Intelligence Test:Managing Emotions].Statistical analyses involved the use of multivariate and univariate analyses of variance.RESULTS:Analyses conducted on the cognitive domain scores revealed no overall significant difference between groups nor any interaction between group and domain score[F(1,45)=0.73,P=0.649].Analyses conducted on each of the specific tasks within the cognitive domains revealed significantly slower reaction times for false alarm responses on the CPT-IP task in AN[F(1,51)=12.80,P<0.01,Cohen’s d=0.982]and a trend towards poorer performance in AN on the backward component of the WMS?-ⅢSpatial Span task[F(1,51)=5.88,P=0.02,Cohen’s d=-0.665].The finding of slower reaction times of false alarm responses is,however,limited due to the small number of false alarm responses for either group.CONCLUSION:The findings are discussed in terms of poorer capacity to manipulate and process visuospatial material in AN. | Andrea Phillipou Caroline Gurvich David Jonathan Castle Larry Allen Abel Susan Lee Rossell | 2015 | World Journal of Psychiatry2015，5，4： | 1 |
| 3 | Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy显示文摘Although targeted therapies have proven effective and even curative in human leukaemia, resistance often ensues. IDH enzymes are mutated in ~20% of human AML, with targeted therapies under clinical evaluation. We here characterize leukaemia evolution from mutant IDH2 (mIDH2)-dependence to independence identifying key targetable vulnerabilities of mIDH2 leukaemia that are retained during evolution and progression from early to late stages. Mechanistically, we find that mIDH2 leukaemia are metastable and vulnerable at two distinct levels. On the one hand, they are characterized by oxidative and genotoxic stress, in spite of increased 1-carbon metabolism and glutathione levels. On the other hand, mIDH2 leukaemia display inhibition of LSD1 and a resulting transcriptional signature of all-trans retinoic acid (ATRA) sensitization, in spite of a state of suppressed ATRA signalling due to increased levels of PIN1. We further identify GSH/ROS and PIN1/LSD1 as critical nodes for leukaemia maintenance and the combination of ATRA and arsenic trioxide (ATO) as a key therapeutic modality to target these vulnerabilities. Strikingly, we demonstrate that the combination of ATRA and ATO proves to be a powerfully synergistic and effective therapy in a number of mouse and human mIDH1/2 leukemic models. Thus, our findings pave the way towards the treatment of a sizable fraction of human AMLs through targeted APL-like combinatorial therapies. | Vera Mugoni Riccardo Panella Giulia Cheloni Ming Chen Olga Pozdnyakova Dina Stroopinsky Jlenia Guarnerio Emanuele Monteleone Jonathan David Lee Lourdes Mendez Archita Venugopal Menon Jon Christopher Aster Andrew A. Lane Richard Maury Stone Ilene Galinsky José Cervera Zamora Francesco Lo-Coco Manoj Kumar Bhasin David Avigan Letizia Longo John Gerard Clohessy Pier Paolo Pandolfi | 2019 | Cell Research2019，29，6： | 1 |
| 4 | Unprotected Left Main Coronary Disease and ST-Segment Elevation Myocardial Infarction显示文摘 | Michael S. Lee Pooya Bokhoor Seung-Jung Park Young-Hak Kim Gregg W. Stone Imad Sheiban Giuseppe Biondi-Zoccai Dario Sillano Jonathan Tobis David E. Kandzari | 2010 | JACC: Cardiovascular Interventions2010，，： | 1 |
| 5 | Microwave Synthesis of Silver Nanoparticles Using Different Pentose Carbohydrates as Reducing Agents显示文摘 | David S. Chung Hanna Kim Jonathan Ko Justine Lee Bryant Hwang Sohyun Chang ByungJun Kim Sung-Jae Chung | 2018 | Journal of Chemistry and Chemical Engineering2018，12，1： | 1 |
| 6 | Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer显示文摘 | Geeta Kulkarni Dmitry A. Turbin Anahita Amiri Sujeeve Jeganathan Miguel A. Andrade-Navarro Thomas D. Wu David G. Huntsman Jonathan M. Lee | 2007 | Breast Cancer Research and Treatment2007，，1： | 1 |
| 7 | Association of albuminuria with systolic and diastolic left ventricular dysfunction in type 2 diabetes显示文摘 | Jennifer E Liu David C Robbins Vittorio Palmieri Jonathan N Bella Mary J Roman Richard Fabsitz Barbara V Howard Thomas K Welty Elisa T Lee Richard B Devereux | 2003 | Journal of the American College of Cardiology2003，，11： | 1 |
| 8 | Self-reported and behavioural impulsivity in anorexia nervosa显示文摘AIM To examine how self-reported and behavioural impulsivity are related in anorexia nervosa(AN).METHODS Twenty-four females with AN and 25 healthy controls(HC) participant in the study.Self-reported impulsivity was assessed with the Barratt Impulsiveness Scale(BIS-11).The scale yields three second-order factors:Attentional,motor and non-planning.Behavioural impulsivity was investigated with the continuous performance test(CPT),a computer-based task of sustained attention in which numbers are flashed briefly on screen and participants are required to click the mouse when the same number appears consecutively.The rate of commission and omission errors can be used a measure of behavioural imulsivity.RESULTS AN participants self-reported increased attentional [AN:20.67(3.64),HC:13.88(2.91),P = 0.001] and reduced motor impulsivity [AN:11.55(2.28),HC:14.08(2.78),P = 0.002].The rate of omission or commission errors on the CPT did not differ between groups(P > 0.05).BIS-11 and CPT measures did not significantly correlate,but attentional impulsivity was related to negative mood states in AN(depression:r = 0.52,P = 0.010,anxiety:r = 0.55,P = 0.006,stress:r = 0.57,P = 0.004).CONCLUSION The discrepancy between self-reported and behavioural impulsivity are discussed in terms of perfectionism in AN.Furthermore,it is suggested that improving negative mood states may resolve this inconsistency in AN. | Andrea Phillipou Larry Allen Abel David Jonathan Castle Caroline Gurvich Matthew Edward Hughes Susan Lee Rossell | 2016 | World Journal of Psychiatry2016，6，3： | 0 |
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