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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: A survival prediction model to facilitate clinical decision making显示文摘 | Andrew W. Bradbury Donald J. Adam Jocelyn Bell John F. Forbes F. Gerry R. Fowkes Ian Gillespie Charles Vaughan Ruckley Gillian M. Raab | 2010 | Journal of Vascular Surgery2010，，： | 2 |
| 3 | Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: An intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy显示文摘 | Andrew W. Bradbury Donald J. Adam Jocelyn Bell John F. Forbes F. Gerry R. Fowkes Ian Gillespie Charles Vaughan Ruckley Gillian M. Raab | 2010 | Journal of Vascular Surgery2010，，： | 1 |
| 4 | Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial显示文摘 | Christina Davies Hongchao Pan Jon Godwin Richard Gray Rodrigo Arriagada Vinod Raina Mirta Abraham Victor Hugo Medeiros Alencar Atef Badran Xavier Bonfill Joan Bradbury Michael Clarke Rory Collins Susan R Davis Antonella Delmestri John F Forbes Peiman Hadd | 2012 | The Lancet2012，，： | 1 |
| 5 | Diamond and hard carbon films for microelectromechanical systems (MEMS) : A nanotribological study显示文摘 | Forbes I S John I B | 2002 | Thin Solid Films2002，，： | 1 |
| 6 | Fictitious crack propagation in fiberrein-forced concrete beams显示文摘 | John Forbes Olesen | 2001 | Engineering Mechanics2001，127，3： | 1 |
| 7 | The effects of phonological and semantic features of sentence-ending words on visual event-related brain potentials显示文摘 | John F. Connolly Natalie A. Phillips Kelly A.K. Forbes | 1995 | Electroencephalography and Clinical Neurophysiology1995，，4： | 1 |
| 8 | The Bone Marrow Functionally Contributes to Liver Fibrosis显示文摘 | Francesco P. Russo Malcolm R. Alison Brian W. Bigger Eunice Amofah Aikaterini Florou Farhana Amin George Bou–Gharios Rosemary Jeffery John P. Iredale Stuart J. Forbes | 2006 | Gastroenterology2006，，6： | 1 |
| 9 | Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality显示文摘 | John H. Boyd Jason Forbes Taka-aki Nakada Keith R. Walley James A. Russell | 2011 | Critical Care Medicine2011，，2： | 1 |
| 10 | Can different patient satisfaction survey methods yield consistent results Comparison of three surveys 显示文摘 | Geoff Cohen John Forbes Michael Garraway | 1996 | papers1996:71996，1996，： | 1 |
| 11 | The unmanned guided vehicle system显示文摘 | John Gilmore F Harold Forbes Kevin Payne | 1995 | SPIE Mobile Robots X1995，24，631： | 1 |
| 12 | An Integrated Process Model of Stereotype Threat Effects on Performance显示文摘 | Schmader T Johns M Forbes C | | 0，，115： | 1 |
| 13 | Risk Factors for Surgical Site Infection After Cardiac Surgery in Children显示文摘 | John M. Costello Dionne A. Graham Debra Forbes Morrow Jacqueline Morrow Gail Potter-Bynoe Thomas J. Sandora Frank A. Pigula Peter C. Laussen | 2010 | The Annals of Thoracic Surgery2010，，6： | 1 |
| 14 | Diamond and Hard Carbon Films for Microelectromechanical Systems (MEMS)-A Nanotribological Study 显示文摘 | Ian S Forbes John I B Wilson | 2002 | Thin Solid Films2002，，420421： | 1 |
| 15 | Design of optimal strictly positive real controllers using numerical optimization for the control of flexible robotic systems显示文摘 | James Richard Forbes Christopher John Damaren | 2011 | Journal of the Franklin Institute2011，，8： | 1 |
| 16 | Microsatellite evolution in congeneric mammals: domestic and bighorn sheep 显示文摘 | Stephen H Forbes John T Hogg Fiona C Buchanan | 1995 | Mol Biol Evol1995，12，6： | 1 |
| 17 | Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality显示文摘 | John H. Boyd Jason Forbes Taka-aki Nakada Keith R. Walley James A. Russell | 2011 | Critical Care Medicine2011，，2： | 1 |
| 18 | The Bone Marrow Functionally Contributes to Liver Fibrosis显示文摘 | Francesco P. Russo Malcolm R. Alison Brian W. Bigger Eunice Amofah Aikaterini Florou Farhana Amin George Bou–Gharios Rosemary Jeffery John P. Iredale Stuart J. Forbes | 2006 | Gastroenterology2006，，6： | 1 |
| 19 | PROPELLER MRI:Clinical testing of a novel technique for quantification and compensation of head motion显示文摘 | Kirsten P N Forbes James G Pipe John P Karis | 2001 | J Magn Reson Imag2001，14，3： | 1 |
| 20 | An Integrated Process Model of Stereotype Threat Effects on Performance 显示文摘 | SCHMADER T JOHNS M FORBES C | 2008 | Psychological Review2008，115，2： | 1 |
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