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| 1 | Bilateral vs unilateral placement of metal stents for inoperable highgrade hilar biliary strictures: A systemic review and meta-analysis显示文摘BACKGROUND Bilateral vs unilateral biliary stenting is used for palliation in malignant biliary obstruction.No clear data is available to compare the efficacy and safety of bilateral biliary stenting over unilateral stenting.AIM To assess the efficacy and safety of bilateral vs unilateral biliary drainage in inoperable malignant hilar obstruction.METHODS PubMed,Embase,Scopus,and Cochrane databases,as well as secondary sources(bibliographic review of selected articles and major GI proceedings),were searched through January 2019.The primary outcome was the re-intervention rate.Secondary outcomes were a technical success,early and late complications,and stent malfunction rate.Pooled odds ratio(OR)and 95%confidence interval(CI)were calculated for each outcome.RESULTS A total of 9 studies were included(2 prospective Randomized Controlled Study,5 retrospective studies,and 2 abstracts),involving 782 patients with malignant hilar obstruction.Bilateral stenting had significantly lower re-intervention rate compared with unilateral drainage(OR=0.59,95%CI:0.40-0.87,P=0.009).There was no difference in the technical success rate(OR=0.7,CI:0.42-1.17,P=0.17),early complication rate(OR=1.56,CI:0.31-7.75,P=0.59),late complication rate(OR=0.91,CI:0.58-1.41,P=0.56)and stent malfunction(OR=0.69,CI:0.42-1.12,P=0.14)between bilateral and unilateral stenting for malignant hilar biliary strictures.CONCLUSION Bilateral biliary drainage had a lower re-intervention rate as compared to unilateral drainage for high grade inoperable malignant biliary strictures,with no significant difference in technical success,and early or late complication rates. | Munish Ashat Sumant Arora Jagpal S Klair Christopher A Childs Arvind R Murali Frederick C Johlin | 2019 | World Journal of Gastroenterology2019，25，34： | 5 |
| 2 | 早期肝门部胆管癌放疗联合肝胰十二指肠整块切除和原位肝移植后患者长期无瘤存活情况报告显示文摘目的回顾筛查和早期诊断胆管细胞癌和应用全肝及胰十二指肠整块切除-原位肝移植(OLT—Whipple)根治继发于原发性硬化性胆管炎(PSC)的早期肝门部胆管癌的经验。方法采用超声内镜(EUS)、经内镜逆行胰胆管造影(ERCP)并行多级刷片细胞学检查对无症状PSC患者进行筛查。对确诊为胆管癌的患者采用外线柬放疗结合病变局部近距离放射治疗和OLT—Whipple手术进行治疗。结果1988年1月至2001年2月,共对119例PSC患者进行了筛查,并对其中42例运用上述方法进行随访。有8例患者检查出患有胆管癌,其中6例接受了OLT-Whipple手术。在这6例患者中,I期胆管癌4例,Ⅱ期胆管癌2例。这6例患者均接受了OLT—Whipple手术联合外线束放疗和近距离放射疗法。从确诊到实行OLT—Whipple手术的中位时间为144d。1例患者在移植术后55个月死于其他因素,而非肿瘤复发。其他5例无瘤生存达到79、82、108、128、129和145个月。结论对于PSC患者采用ERCP细胞学检查和超声内镜检查可以早期诊断肝门部胆管癌。外放疗和病灶局部放疗联合OLT-Whipple手术整块切除胆道系统有希望获得长期无瘤生存。所有的患者均耐受了这种大范围手术并获得较好的生活质量。该发现支持对并发有PSC的早期肝门部胆管癌患者行OLT—Whipple手术切除整个胆道系统。 | 吴幼民 Frederick C. Johlin Stephen C. Rayhill Chris S. Jensen JIN Xie Frank A. Mitros 肖震宇(译) 黄志勇(译) | 2009 | 中华外科杂志2009，47，15： | 2 |
| 3 | Studies on the role of folic acid and folate-dependent enzymes in human methanol poisoning 显示文摘 | JOHLIN F C FORTMAN C S NGHIEM D D | 1987 | Molecular Pharmacology1987，31，5： | 1 |
| 4 | Thoracoscopic splanchnicectomy for chronic pancreatitispain显示文摘 | James WM Frederick C Johlin DP | 1996 | Surgery1996，120，4： | 1 |
| 5 | Complications and survival associated with operative procedures in patients with unresectable pancreatic head adenocarcinoma显示文摘 | Philip M. Spanheimer Anthony R. Cyr Junlin Liao Frederick C. Johlin Hisakazu Hoshi James R. Howe James J. Mezhir | 2014 | J Surg Oncol2014，，7： | 1 |
| 6 | Sphincter of Oddi Dysfunction Following Liver Transplantation显示文摘 | Douzdjian V Abecassis M Johlin F | 1994 | Digest Dis Sci1994，39，2： | 1 |
| 7 | Origins of structural hole traps in hydrogenated amorphous silicon显示文摘 | Johlin E Wagner L K Buonassisi T | 2013 | Physical Review Letters2013，110，14： | 1 |
| 8 | Hyperbaric oxygen treatment of hemorrhagic radiation - induced gastritis after esoph- agectomy显示文摘 | Kernstine KH Grecnsmith JE Johlin FC | 2005 | ann Thorac Surg2005，80，3： | 1 |
| 9 | Hyperbaric oxygen treat- ment of hemorrhagic radiation - induced gastritis after esophagectomy 显示文摘 | Kernstine KH Greensmith JE Johlin FC | 2005 | Ann Thorac Surg2005，80，3： | 1 |
| 10 | Pharmcokinetics of dirithromycin in patients with impaired hepatic function 显示文摘 | LaBreque D Johlin F Janda R | 1993 | Antimicrob Chemother1993，32，5： | 1 |
| 11 | Long-term follow-up of thoracoscopic splanchnicectomy for chronic pancreatitis pain显示文摘 | Maher JW Johlin FC Heitshusen D | 2001 | Surg Endosc2001，15，7： | 1 |
| 12 | Fructose intolerance: an under-recognized problem显示文摘 | Young K Choi Fredrick C Johlin Robert W Summers Michelle Jackson Satish S.C Rao | 2003 | The American Journal of Gastroenterology2003，，6： | 1 |
| 13 | Long-term,tumor-free survival after radiotherapy combining hepatectomy-Whipple en bloc and orthotopic liver transplantation for early-stage hilar cholangiocarcinoma显示文摘 | Wu Y Johlin FC Rayhill SC | | 0，，3： | 1 |
| 14 | Studies on the role of folic acid and folate-dependent enzymes in human methanol poisoning显示文摘 | Johlin FC Fortman CS Nghiem DD | 1987 | Mol Pharmacol1987，31，5： | 1 |
| 15 | Studies on the mechanism of methanol poisoning:purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase显示文摘 | Johlin FC Swain E Smith C | 1989 | Mol Pharmacol1989，35，6： | 1 |
| 16 | Xylanolysis by cocultures of the tureen fungus Neocelfimastix frontalis and rurninal heeteria显示文摘 | Withers S E Johlin K N | 1991 | Lett Appl Microhiol1991，12，： | 1 |
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