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| 1 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Animal plant warfare and secondary metabolite evolution显示文摘The enduring discussion,why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of manhood.In recent years,the concept of an animal plant warfare emerged,which focused on the co-evolution between plants and herbivores.As a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,which paved the way for adapted animal physiques.Plants evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest them.As a result of this selective pressure,animals developed special enzymes,e.g.cytochrome P450 monooxigenases(CYP450)that metabolize xenobiotic phytochemicals.As a next step in the evolutionary competition between plants and animals,plants evolved to produce non-toxic pro-drugs,which become toxic only after ingestion by animals through metabolization by enzymes such as CYP450.Because these sequestered evolutionary developments call to mind an arms race,the term animal plant warfare has been coined.The evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays. | Steffen WÖLL Sun Hee KIM Henry Johannes GRETEN Thomas EFFERTH | 2013 | Natural Products and Bioprospecting2013，3，1： | 2 |
| 4 | Design and implemen- tation of a highly efficient three-level T-type converter for low-voltage applications显示文摘 | Schweizer Mario Kolar Johann W | 2013 | IEEE Trans on Power Electronics2013，28，2： | 1 |
| 5 | Synthesis and haemolytic activity of oleanolic acid trisaccharides显示文摘 | Robert W Johann J | 1999 | Monatshefte fur Chemie Chemical Monthly1999，130，： | 1 |
| 6 | HXT5 expression is determined by growth rates in Saccharomyces cerevisiae 显示文摘 | Rene Verwace Johannes W G Paalman Astrid Hogenkamp etal | 2002 | Yeast2002，19，： | 1 |
| 7 | Poly- morphous low - grade adenocarcinoma and adenoid cystic carcino- ma: a review and comparison of immunohistochemical markers 显示文摘 | Mark R Darling Johann W Schneider Vincent M Phillips | 2002 | Oral Oncol2002，7，38： | 1 |
| 8 | The develop- ment of QUADAS:a tool for the quality assessment ofstudies of diagnostic accuracy included in systematic re- views 显示文摘 | Penny W Anne WSR Johannes BR | 2003 | BMC Medical Research Methodology2003，3，： | 1 |
| 9 | Atherosclerotic change in the carotid artery bulb as measured by B-modl ultrasound are associated with the extend of coronary atherosclerosis显示文摘 | Johannes H John W Wikstrand H | 1997 | Stroke1997，28，： | 1 |
| 10 | Atherosclerotic change in the carotid artery bulb as measured by B - mode ultrasound are associated with the extent of coronary atherosclerosis显示文摘 | Johannes H John W Wikstrand H | 1997 | Stroke1997，28，： | 1 |
| 11 | Novel three-phase converters显示文摘 | Johann W Kolar Frank Schafmeister Simon D al | 2007 | IEEE Electronics2007，22，5： | 1 |
| 12 | The devel- opment of multiple collector mass spectrometry for isotope ratio measurements 显示文摘 | MICHAEL E W JOHANNES B S | 2005 | Int J Mass Spectrom2005，242，23： | 1 |
| 13 | Argon plasma coagulation in flexible endoscopy of the gastrointestinal tract: in vitro studies 显示文摘 | Johanns W Janssen J Jakobeit C | 1996 | Endoscopy1996，28，： | 1 |
| 14 | Soy isoflavonoidequol modulates the growth of benign and malignant prostatic epithelial cell sinvitro显示文摘 | HEDLUND T E JOHANNES W U MILLER G J | 2003 | Prostat2003，54，1： | 1 |
| 15 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 16 | A second order algorithm for orthogonal proiection onto curves and surfaces显示文摘 | SHIM H JOHANNES W | 2005 | Computer Aided Geometric Design2005，22，： | 1 |
| 17 | Novel three-phase AC-AC sparse matrix converters显示文摘 | Johann W Kolar Frank Schafmeister Simon D R | 2007 | IEEE Transactions on Power Electronics2007，22，5： | 1 |
| 18 | Glyeerol etherification over highly active CaO-based materials: new mechanistic aspects and related colloidal particle formation 显示文摘 | Agnieszka M R Johannes D M Bonny W M K | 2008 | Chemistry-A European Journal2008，14，7： | 1 |
| 19 | Atherosclerotic changes in the carotid artery bulb as measured by B-mode ultrasound are associated with the extent of coronary atherosclerosis 显示文摘 | Johannes H John W Wikstrand H | 1997 | Stroke1997，28，： | 1 |
| 20 | Electron injection and transport in 8-hydroxyquinoline aluminum显示文摘 | M St??el J Staudigel F Steuber J Bl?ssing J Simmerer A Winnacker H Neuner D Metzdorf H.-H Johannes W Kowalsky | 2000 | Synthetic Metals2000，，： | 1 |
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