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| 1 | Systematic review of the prevalence and development of osteoporosis or low bone mineral density and its risk factors in patients with inflammatory bowel disease显示文摘BACKGROUND The inflammatory bowel diseases(IBD),Crohn’s disease(CD)and ulcerative colitis(UC)are chronic,immune-mediated disorders of the digestive tract.IBD is considered to be a risk factor for developing osteoporosis;however current literature on this matter is inconsistent.AIM To assess prevalence and development of osteoporosis and low bone mineral density(BMD),and its risk factors,in IBD patients.METHODS Systematic review of population-based studies.Studies were identified by electronic(January 2018)and manual searches(May 2018).Databases searched included EMBASE and PubMed and abstracts from 2014-2018 presented at the United European Gastroenterology Week,the European Crohn’s and Colitis Organisation congress,and Digestive Disease Week were screened.Studies were eligible for inclusion if they investigated either the prevalence of osteoporosis or osteopenia and/or risk factors for osteoporosis or low BMD in IBD patients.Studies on children under the age of 18 were excluded.Only population-based studies were included.All risk factors for osteoporosis and low BMD investigated in any included article were considered.Study quality and the possibility of bias were analysed using the Newcastle-Ottawa scale.RESULTS Twelve studies including 3661 IBD patients and 12789 healthy controls were included.Prevalence of osteoporosis varied between 4%-9%in studies including both CD and UC patients;2%-9% in studies including UC patients, and 7%-15% instudies including CD patients. Among healthy controls, prevalence ofosteoporosis was 3% and 10% in two studies. CD diagnosis, lower body massindex (BMI), and lower body weight were risk factors associated withosteoporosis or low BMD. Findings regarding gender showed inconsistent results.CD patients had an increased risk for osteoporosis or low BMD over time, whileUC patients did not. Increased age was associated with decreased BMD, and therewas a positive association between weight and BMI and BMD over time. Greatheterogeneity was found in the included studies in terms of study methodologies,definitions and the assessment of osteoporosis, and only a small number ofpopulation-based studies was available.CONCLUSIONThis systematic review found a possible increase of prevalence of osteoporosis inCD cohorts when compared to UC and cohorts including both disease types.Lower weight and lower BMI were predictors of osteoporosis or low BMD in IBDpatients. The results varied considerably between studies. | Sofia Kärnsund Bobby Lo Flemming Bendtsen Jakob Holm Johan Burisch | 2020 | World Journal of Gastroenterology2020，26，35： | 8 |
| 2 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 3 | Meso-Cenozoic tectonic evolution of the Talas-Fergana region of the Kyrgyz Tien Shan revealed by low-temperature basement and detrital thermochronology显示文摘This study provides new low-temperature thermochronometric data, mainly apatite fission track data on the basement rocks in and adjacent to the Talas-Fergana Fault, in the Kyrgyz Tien Shan in the first place.In the second place, we also present new detrital apatite fission track data on the Meso-Cenozoic sediments from fault related basins and surrounding intramontane basins. Our results confirm multistaged Meso-Cenozoic tectonic activity, possibly induced by the accretion of the so-called Cimmerian blocks to the Eurasian margin. New evidence for this multi-staged thermo-tectonic activity is found in the data of both basement and Meso-Cenozoic sediment samples in or close to the Talas-Fergana Fault.Zircon(U-Th)/He and apatite fission track data constrain rapid Late TriassiceE arly Jurassic and Late JurassiceE arly Cretaceous basement cooling in the Kyrgyz Tien Shan around 200 Ma and 130 -100 Ma respectively. Detrital apatite fission track results indicate a different burial history on both sides of the Talas-Fergana Fault. The apatite fission track system of the Jurassic sediments in the Middle Tien Shan unit east of the Talas-Fergana Fault is not reset, while the Jurassic sediments in the Fergana Basin and Yarkand-Fergana Basin, west of the fault zone, are partially and in some cases even totally reset. The totally reset samples exhibit Oligocene and Miocene ages and evidence the Cenozoic reactivation of the western Kyrgyz Tien Shan as a consequence of the India-Eurasia convergence. | Simon Nachtergaele Elien De Pelsmaeker Stijn Glorie Fedor Zhimulev Marc Jolivet Martin Danisík Mikhail M.Buslov Johan De Grave | 2018 | Geoscience Frontiers2018，9，5： | 4 |
| 4 | Towards a unified paradigm for sequence‐based identification of fungi显示文摘 | Urmas K?ljalg R. Henrik Nilsson Kessy Abarenkov Leho Tedersoo Andy F. S. Taylor Mohammad Bahram Scott T. Bates Thomas D. Bruns Johan Bengtsson‐Palme Tony M. Callaghan Brian Douglas Tiia Drenkhan Ursula Eberhardt Margarita Due?as Tine Grebenc Gareth W. Gri | 2013 | Mol Ecol2013，，21： | 2 |
| 5 | Regulation of adipocyte differentiation显示文摘 | Hana K Johan A | 2001 | Ann Med2001，33，8： | 1 |
| 6 | Osseous Lesions显示文摘 | Johan B Herman K | 1993 | Radiologic Clinic of North America1993，31，： | 1 |
| 7 | A century of gestalt psychology in visual perception: perceptual groupingand figure ground organization显示文摘 | JOHAN W JAMES H E MICHAEL K | 2012 | Psychological Bulletin2012，138，6： | 1 |
| 8 | Relationship between human papillomavirus type 16 in the cervix and intraepithelial neoplasia显示文摘 | Bram TH Frank S Johan K | 1999 | Obstet Gyneeol1999，93，： | 1 |
| 9 | The anatomy of the Facebook social graph显示文摘 | Johan U Brian K Lars B | 2011 | The Anatomy of Facebook2011，，： | 1 |
| 10 | Mineral absorption and excretion as affected by microbial phytase,and their effect on energy metabolism in young piglets 显示文摘 | Arie K K Walter J J G Johan W S | 2005 | J Nutr2005，135，： | 1 |
| 11 | Direct orthogonal signal correction 显示文摘 | Westerhuis Johan A de Jong Sijmen Smilde Age K | 2001 | Chemometries and Intelligent Laboratory Systems(S0169-7439)2001，56，： | 1 |
| 12 | Accuracy of migration analysis in hip arthroplasty Digitized and conventional radiography, compared to radiostereometry in 51 patients显示文摘 | Henrik Malchau Johan K? rrholm Yu Xing Wang Peter Herberts | 1995 | Acta Orthopaedica1995，，5： | 1 |
| 13 | Identification of MIMO Hammerstein models using least squares support vector machines 显示文摘 | Ivan Goethals Kristiaan Pelekmans Johan A K Suykens Bart De Moor | 2005 | Automatica2005，41，7： | 1 |
| 14 | Experimental investigation of the Tra-nsformation and Release to Gas Phase of Potas- sium and Chlorine during Straw Pyrolysis 显示文摘 | P A Jensen F J Frandsen K D Johan - senetal | 2000 | Energy & Fuels2000，14，6： | 1 |
| 15 | Vitreous:a barrier to nonviral ocular gene therapy显示文摘 | Peeters L Sanders NN Braeckmans K Boussery K Johan Voorde VD Smedt SC | | 0，，10： | 1 |
| 16 | Loss of inositol 1,4,5-triphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer'dise ase neurofibrillary pathology显示文摘 | Johan F Willyl B | 1998 | Brain Res1998，796，： | 1 |
| 17 | Micromotion of femoral stems in total hip arthroplasty显示文摘 | Johan K Henrik M Gothenberg | 1994 | J Bone Joint Surg1994，，： | 1 |
| 18 | Collaborative trial validation study of two methods, one based on high performance liquid chromatography tandem mass spectrometry and on gas chromatography - mass spectrometry for the determination of acrylarnide in bakery and potato products 显示文摘 | Thomas W Lubomir K Johan R | 2006 | Journal of Chromatography A2006，1132，： | 1 |
| 19 | Midterm angiographic outcome of single - vessel intracoronary stent placement in diabetic versus nondiabetic patients: A matched comparative study显示文摘 | Lau K W Ding Z P Johan A | 1998 | Am Heart J1998，136，1： | 1 |
| 20 | Different patterns of cartilage wear in medial and lateral gonarthrosis显示文摘 | Jonas Weidow John Pak Johan K?rrholm | 2002 | Acta Orthopaedica2002，，3： | 1 |
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