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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Reflection Z-scan technique for measurements of optical properties of surface显示文摘 | Petrov D V Gomes A S L de Arauújo C B | | 0，，： | 1 |
| 3 | Mechanical and creep properties of the cast magnesium alloy显示文摘 | Park K C Kim B H Jo S M | 2012 | Applied Mechanics and Materials2012，，1： | 1 |
| 4 | 查看详情显示文摘 | Hong B K Jo W H Lee S C KimJ | | 0，，： | 1 |
| 5 | 显示文摘 | Park S H Jo S M Kim D Y Lee W S Kim B C | 2005 | Synthetic Metals2005，150，： | 1 |
| 6 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
| 7 | The impact of social support on health related quality of life in persons vin epilepsy显示文摘 | Charyton C Elliott JO Lu B | 2009 | Epilepsy Behav2009，16，： | 1 |
| 8 | Activation of peroxisome pro-liferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism显示文摘 | Jo SH Caemus B | 2007 | Pathol2007，170，2： | 1 |
| 9 | Masked hypertension:a systematic review显示文摘 | Guillaume B Pierre C Jol M | 2008 | J Hypertens2008，26，9： | 1 |
| 10 | The Ectodysp lasin and NFkB signalling pathways in odontogenesis 显示文摘 | JO - Maree C James B 1 Pail T S | 2005 | Archives of Oral Biology2005，50，： | 1 |
| 11 | Stationary and non stationary learning characteristics of t he LMS adaptive filter显示文摘 | WIDROW B MCCOOL J M LARMOR E M G JO HN2SON C R | | 0，，08： | 1 |
| 12 | Landslided Hazard Zoning Using the GIS Approach-A Case Study from the Ramganga Catchment, Himalayas 显示文摘 | Gupta R P Jo shi B C | 1990 | Engineering Geology1990，28，2： | 1 |
| 13 | Functional properties of raw and cooked pork patties with added irradiated, freeze-dried green tea leaf extract powder during storage at 4C 显示文摘 | Jo C Son J H Son C B | 2003 | Meat Science2003，64，1： | 1 |
| 14 | Micro electrochemical machining for complex internal micro features 显示文摘 | JO C H KIM B H CHU C N | 2009 | CIRP Annals - Manufacturing Technology2009，58，1： | 1 |
| 15 | Soft Tissue Balancing of Varus Arthritic Knee in Minimally Invasive Surgery Total Knee Arthroplasty:Comparison between Posterior Oblique Ligament Release and Superficial MCLRelease显示文摘 | Seo J G Moon Y W Jo B C | 2013 | Knee Surg Relat Res2013，25，2： | 1 |
| 16 | Functional properties of raw and cooked pork patties with added irradiated, freeze-dried green tea leaf extract powder during storage at 4℃显示文摘 | Jo C Son J H Son C B | 2003 | Meat Science2003，64，1： | 1 |
| 17 | The successive projections algorithm for variable selection in spectroscopic multicomponent analysis显示文摘 | ARA(U)JO M C U SALDANHA T C B GALV(A)O R K H | 2001 | Chemometrics and Intelligent Laboratory Systems2001，57，2： | 1 |
| 18 | Identification of Capsicum species using SNP markers based on high resolution melting analysis显示文摘 | Jeong H J Jo Y D Park S W Kang B C | | 0，，： | 1 |
| 19 | Differential growth factor retention by platelet-rich plasma composites 显示文摘 | Rick C Jennifer Jo Andrea B | 2005 | Oral Maxillofac Surg2005，63，4： | 1 |
| 20 | Quantitative comparisons of in situ microbial biodiversity by signature biomarker analysis显示文摘 | White D C Stair JO Ringelberg D B | 1996 | Journal ofIndustry Microbiology1996，17，： | 1 |
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