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| 1 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 2 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 3 | Influences of water treatment agents on oil-water interfacial properties of oilfield produced water显示文摘The emulsion stability of oilfield produced water is related to the oil-water interfacial film strength and the zeta potential of the oil droplets. We investigated the effects of water treatment agents (corrosion inhibitor SL-2, scale inhibitor HEDP, germicide 1227, and flocculant polyaluminium chloride PAC) on the stability of oilfield produced water. The influence of these treatment agents on oil-water interfacial properties and the mechanism of these agents acting on the oilfield produced water were studied by measuring the interfacial shear viscosity, interfacial tension and zeta electric potential. The results indicated that the scale inhibitor HEDP could increase the oil-water interfacial film strength, and it could also increase the absolute value of the zeta potential of oil droplets. HEDP played an important role in the stability of the emulsion. Polyaluminum chloride (PAC) reduced the stability of the emulsion by considerably decreasing the absolute value of the zeta potential of oil droplets. Corrosion inhibitor SL-2 and germicide 1227 could decrease the oil-water interfacial tension, whereas they had little influence on oil-water interfacial shear viscosity and oil-water interfacial electricity properties. | Guo Jixiang Cao Jingjing Li Mingyuan Xia Haiying | 2013 | Petroleum Science2013，10，3： | 9 |
| 4 | Use of Probiotics in Aquaculture显示文摘Diseases of cultured animal and environmental pollution are very important problems in aquaculture. The use of probiotics in aquaculture has more advantages than the use of antibiotics and chemicals in aquaculture. This review introduces the use and mechanisms of the probiotics in aquaculture. | 王祥红 Du Zongjun Chen Jixiang Li Yun Ji Weishang Xu Huaishu | 2002 | High Technology Letters2002，8，3： | 6 |
| 5 | Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization显示文摘Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. | Yaxin Zhang Mingbo Pu Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai Fei Zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Opto-Electronic Advances2022，5，11： | 6 |
| 6 | Influence of polymers on the stability of Gudao crude oil emulsions显示文摘The influence of different types and concentrations of polymers on the stability of Gudao crude oil emulsion was investigated by measuring the volume of water separated from the emulsions and the interfacial shear viscosity of the oil/water interfacial film.Experimental results indicate that the simulated water-in-oil emulsion with 40 mg/L of partially hydrolyzed polyacrylamide(HPAM)3530S could be easily broken by adding demulsifier C and was readily separated into two layers.However, HPAM AX-74H and hydrophobically associating water-soluble polymer(HAP)could stabilize the crude oil emulsion.With increasing concentration of AX-74H and HAP,crude oil emulsions became more stable.Water droplets were loosely packed in the water-in model oil emulsion containing HPAM 3530S, but water droplets were smaller and more closely packed in the emulsion containing AX-74H or HAP.The polymers could be adsorbed on the oil/water interface,thereby increasing the strength of the interfacial film and enhancing the emulsion stability. | Lin Meiqin Zhang Chunling Zong Hua Li Mingyuan Fang Hongbo Guo Jixiang | 2008 | Petroleum Science2008，5，2： | 6 |
| 7 | Selective hydrogenation of acetylene on SiO_2-supported Ni-Ga alloy and intermetallic compound显示文摘Ni/Si O_2 and bimetallic Ni_xGa/SiO_2 catalysts with different Ni/Ga atomic ratios(x = 10~2) were investigated for the selective hydrogenation of acetylene.It was found that Ni_xGa/SiO_2 showed higher selectivity to ethylene than Ni/Si O_2.This is attributed to the formation Ni-Ga alloy and Ni3 Ga intermetallic compound(IMC) where there was a charge transfer from Ga to Ni,which is favorable for reducing the adsorption strength and amount of ethylene on Ni atoms.As a result,the over-hydrogenation,the C–C bond hydrogenolysis and the polymerization were suppressed,and subsequently the selectivity to ethylene was enhanced.With the decrease of Ni/Ga atomic ratio,the activity and stability of the Ni_xGa/SiO_2 catalysts increased first and then decreased,while the ethylene selectivity tended to increase.Ni_5 Ga/SiO_2 exhibited the best performance.Under the conditions of 180 °C,0.1 MPa,and a reactant(1.0 vol% acetylene,5.0 vol% H_2 and 94 vol% N_2) with the space velocity of 36,000 m L h^(-1) g^(-1),the acetylene conversion maintained at 100% on Ni_5 Ga/SiO_2 during 120 h time on stream and the selectivity to ethylene was 75%~81%after reaction for 68 h.It was also found that the formation of Ni-Ga alloy and Ni_3 Ga IMC suppressed the incorporation of carbon to form NiCx,subsequently enhancing the catalyst stability.Additionally,with increasing the Ga content,the catalyst acid amount and strength tended to increase,which promoted the polymerization and carbon deposition and so the catalyst deactivation. | Lei Wang Fengxu Li Yanjun Chen Jixiang Chen | 2019 | Journal of Energy Chemistry2019，28，2： | 6 |
| 8 | REGULATION OF FLOW AND SEDIMENT LOAD IN THE YELLOW RIVER显示文摘Small runoff, large sediment load, and incompatible relationship of flow and sediment load are very important characteristics of the Yellow River. They are also the crux of the most prominent problems of the Yellow River. To solve these problems, the regimes of flow and sediment load have to be improved by increasing water, reducing sediment load, and by using reservoirs to regulate flow and sediment load. The results of experiments for regulating the flow and sediment load in the last three years by the Xiaolangdi Reservoir have indicated that this measure is a realistic and effective way to mitigate the prominent problems in flood control of the Lower Yellow River at present and in the near future. However, the regulation system is still imperfect. It is advisable to speed up the pace of research and construction of the system for regulating flow and sediment load. | Wenxue LI Jixiang LIU Zhanwei WAN | 2007 | International Journal of Sediment Research2007，22，2： | 5 |
| 9 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 10 | Study of asphaltene deposition from Tahe crude oil显示文摘Borehole blockage caused by asphaltene deposition is a problem in crude oil production in the Tahe Oilfield, Xinjiang, China. This study has investigated the influences of crude oil compositions, temperature and pressure on asphaltene deposition. The asphaltene deposition trend of crude oil was studied by saturates, aromatics, resins and asphaltenes (SARA) method, and the turbidity method was applied for the first time to determine the onset of asphaltene flocculation. The results showed that the asphaltene deposition trend of crude oil by the turbidity method was in accordance with that by the SARA method. The asphaltene solubility in crude oil decreased with decreasing temperature and the amount of asphaltene deposits of T739 crude oil (from well T739, Tahe Oilfield) had a maximum value at 60 o C. From the PVT results, the bubble point pressure of TH10403CX crude oil (from well TH10403CX, Tahe Oilfield) at different temperatures can be obtained and the depth at which the maximum asphaltene flocculation would occur in boreholes can be calculated. The crude oil PVT results showed that at 50 , 90 and 130 o C, the bubble point pressure of TH10403CX crude oil was 25.2, 26.4 and 27.0 MPa, respectively. The depth of injecting asphaltene deposition inhibitors for TH10403CX was determined to be 2,700 m. | CHEN Chaogang GUO Jixiang AN Na REN Bo LI Yaguang JIANG Qingzhe | 2013 | Petroleum Science2013，10，1： | 5 |
| 11 | Influence and mechanism of N-(3-oxooxtanoyl)-L-homoserine lactone(C_8-oxo-HSL) on biofilm behaviors at early stage显示文摘N-acyl-homoserines quenching,enzymatic quenching of bacterial quorum sensing,has recently applied to mitigate biofilm in membrane bioreactor.However,the effect of AHLs on the behavior of biofilm formation is still sparse.In this study,Pseudomonas aeruginosa biofilm was formed on ultra-filtration membrane under a series of N-(3-oxooxtanoyl)-L-homoserine lactone(C8-oxo-HSL)concentrations.Diffusing C8-oxo-HSL increased the growth rate of cells on biofilm where the concentration of C8-oxo-HSL was over 10-7g/L.The C8-oxo-HSL gradient had no observable influence on cell density and extracellular polymeric substances of biofilm with over 10-7g/L C8-oxo-HSL.Surprisingly,10-11-10-8g/L of C8-oxo-HSL had no effect on cell growth in liquid culture.The cell analysis demonstrated that the quorum sensing system might enhance the growth of neighboring cells in contact with surfaces into biofilm and may influence the structure and organization of biofilm. | Siqing Xia Lijie Zhou Zhiqiang Zhang Jixiang Li | 2012 | Journal of Environmental Sciences2012，24，12： | 4 |
| 12 | Recent active thermal management technologies for the development of energy-optimized aerospace vehicles in China显示文摘Recently, the development of modern vehicles has brought about aggressive integration and miniaturization of on-board electrical and electronic devices. It will lead to exponential growth in both the overall waste heat and heat flux to be dissipated to maintain the devices within a safe temperature range. However, both the total heat sinks aboard and the cooling capacity of currently utilized thermal control strategy are severely limited, which threatens the lifetime of the on-board equipment and even the entire flight system and shrink the vehicle’s flight time and range. Facing these thermal challenges, the USA proposed the program of 'INVENT' to maximize utilities of the available heat sinks and enhance the cooling ability of thermal control strategies. Following the efforts done by the USA researchers, scientists in China fought their ways to develop thermal management technologies for Chinese advanced energy-optimized airplanes and spacecraft. This paper elaborates the available on-board heat sinks and aerospace thermal management systems using both active and passive technologies not confined to the technology in China. Subsequently, active thermal management technologies in China including fuel thermal management system, environment control system, non-fuel liquid cooling strategy are reviewed. At last, space thermal control technologies used in Chinese Space Station and Chang’e-3 and to be used in Chang’e-5 are introduced.Key issues to be solved are also identified, which could facilitate the development of aerospace thermal control techniques across the world. | Jixiang WANG Yunze LI Xiangdong LIU Chaoqun SHEN Hongsheng ZHANG Kai XIONG | 2021 | Chinese Journal of Aeronautics2021，34，2： | 4 |
| 13 | Thioetherification of isoprene and butanethiol on transition metal phosphides显示文摘Thioetherification between mercaptan and diolefin is an efficient process to remove mercaptans in FCC gasoline at mild condition, during which the selective hydrogenation of diolefin to monoolefin is also expected. Here, Si O2 supported transition metal(Fe, Co, Ni, Mo and W) phosphides were tested for the thioetherification of isoprene and butanethiol on a fixed-bed reactor at 120 °C and 1.5 MPa H2, and their structure before and after reaction was characterized by means of XRD, HRTEM, N2 sorption, CO chemisorption, NH3-TPD, XPS and TG. It was found that, among different metal phosphides, Mo P/Si O2 showed the best performance, and the optimal nominal Mo P loading was 25%. Apart from the nature of metal, the density of metal and acid sites determined the catalyst performance. Metal site was mainly responsible for hydrogenation of isoprene, while acid site dominantly contributed to the thioetherification and the polymerization of olefins. Moreover, a balance between metallic and acidic functions is required to arrive at a desired performance. Excessive metal sites or acid sites led to the over-hydrogenation of isoprene or the severe polymerization of olefins, respectively. 25%Mo P/Si O2 was tested for 37 h time on stream, and butanethiol conversion maintained at 100%; although isoprene conversion remarkably decreased, the selectivity to isopentenes exceeded 80% after reaction for 11 h. We suggest that the deactivation of Mo P/Si O2 is mainly ascribed to the butanethiol poisoning and the carbonaceous deposit, especially the former. | Tianyu Ren Mingfeng Li Yang Chu Jixiang Chen | 2018 | Journal of Energy Chemistry2018，27，3： | 3 |
| 14 | A flexible thermoelectric device based on a Bi_(2)Te_(3)-carbon nanotube hybrid显示文摘Thermoelectric(TE)materials and devices have attracted great attention due to their ability to convert waste heat to electrical power and active cooling.However,the conventional bulk TE materials are inorganic semiconductors with inherent brittleness and rigidity.They cannot closely contact curved heat sources and sinks,which limits their application in modern electronics.It remains a big challenge to fabricate high-performance TE materials and devices with good flexibility.Here,we report a flexible TE device comprised of a single wall carbon nanotube(SWCNT)network and(0001)-textured Bi_(2)Te_(3)nanocrystals prepared by a magnetron sputtering technique.The unique Bi_(2)Te_(3)-SWCNT hybrid structure has a TE figure of merit(ZT)value of^0.23 at^330 K.A prototype TE device made of this hybrid gives a maximum output power density of^0.93 m W cm^(-2)under a temperature difference of 25 K at ambient temperature and shows good flexibility under bending.Our results open up a new way to the development of flexible TEs and their application in self-powered portable devices. | Ying Li Jixiang Qiao Yang Zhao Qing Lan Pengyan Mao Jianhang Qiu Kaiping Tai Chang Liu Huiming Cheng | 2020 | Journal of Materials Science & Technology2020，58，23： | 3 |
| 15 | Rare earth doping effects on superconducting properties of MgB_2:A review显示文摘Rare earth(RE) elements and their compounds have been doped into MgB_2 since the discovery of the superconductivity of MgB_2. The doping effects of RE elements and RE compounds are summarized in terms of different doping methods and the accompanying variations in the superconducting transition temperature, upper critical field, irreversibility field, and critical current density(Jc). Conclusions are drawn on the doping mechanisms to demonstrate the possibility of improvement of Jcin the future. REBy phase inclusions are observed in MgB_2 as nano-pinning centers with significant enhancement of Jcin MgB_2 doped with Y, La, Dy, Ho, Nd, etc. Furthermore, some REs with larger magnetic moments will provide more efficient flux pinning centers with larger pinning forces, which is different with the doping effects and mechanism of ferromagnetic transition metals in MgB_2. The co-doping effects of RE with other dopants are also reviewed due to the multiple advantages of different doping mechanisms. | Wenxian Li Jixiang Kang Siwei Fu Yemin Hu Pengfei Hu Mingyuan Zhu Ying Li | 2019 | Journal of Rare Earths2019，37，2： | 2 |
| 16 | Deoxygenation of methyl laurate to hydrocarbons on silica-supported Ni-Mo phosphides: Effect of calcination temperatures of precursor显示文摘SiO2-supported Ni-Mo bimetallic phosphides were prepared by temperature-programmed reduction(TPR) method from the phosphate precursors calcined at different temperatures. Their properties were characterized by means of ultraviolet-visible diffuse reflectance spectroscopy(UV-Vis DRS), H2temperature-programmed reduction(H2-TPR), X-ray diffraction(XRD), transmission electron microscopy(TEM), CO chemisorption, H2 and NH3temperature-programmed desorptions(H2-TPD and NH3-TPD). Their catalytic performances for the deoxygenation of methyl laurate were tested in a fixed-bed reactor. When the precursors were calcined at 400 and 500?C, respectively, Ni Mo P2 phase could be formed apart from Ni2 P and Mo P phases in the prepared C400 and C500 catalysts. However, when the precursors were calcined at600, 700 and 800°C, respectively, only Ni2 P and Mo P phases could be detected in the prepared C600, C700 and C800 catalysts. Also, in C400, C500 and C600 catalysts, Mo atoms were found to be entered in the lattice of Ni2 P phase, but the entering extent became less with the increase of calcination temperature. As the calcination temperature of the precursor increased, the interaction between Ni and Mo in the prepared catalysts decreased, and the phosphide crystallite size tended to increase, subsequently leading to the decrease in the surface metal site density and the acid amount. C600 catalyst showed the highest activity among the tested ones for the deoxygenation of methyl laurate. As the calcination temperature of the precursor increased, the selectivity to C12 hydrocarbons decreased while the selectivity to C11 hydrocarbons tended to increase. This can be mainly attributed to the decreased Ni-Mo interaction and the increased phosphide particle size. In sum, the structure and performance of Ni-Mo bimetallic phosphide catalyst can be tuned by the calcination temperature of precursor. | Zhengyi Pan Rijie Wang Mingfeng Li Yang Chu Jixiang Chen | 2015 | Journal of Energy Chemistry2015，24，1： | 2 |
| 17 | A surgical simulation system for predicting facial soft tissue deformation显示文摘In the field of cranio-maxillofacial(CMF)surgery, surgical simulation is becoming a very powerful tool to plan surgery and simulate surgical results before actually performing a CMF surgical procedure.Reliable prediction of facial soft tissue changes is in particular essential for better preparation and to shorten the time taken for the operation. This paper presents a surgical simulation system to predict facial soft tissue changes caused by the movement of bone segments during CMF surgery. Two experiments were designed to test the feasibility of this simulation system. The test results demonstrate the feasibility of fast and good prediction of post-operative facial appearance, with texture. Our surgical simulation system is applicable to computer-assisted CMF surgery. | Xiaodong Tang Jixiang Guo Peng Li Jiancheng Lv | 2016 | Computational Visual Media2016，2，2： | 2 |
| 18 | Effects of dexamthasone with different doses on aquaporin-4 in brain of intracerebral hemorrhage rats显示文摘Objective:To determine the relationship between the expression of aquaporin-4(AQP4) after intracerebral hemorrhage and dexamethasone treated.Methods:CollagenaseⅦwas injected in caudate nucleus in a stereotaxis frame to establish the intracerebral hemorrhage(ICH) animal models.The intracerebral hemorrhage(ICH) rats were randomly divided into four groups:the sham group (group A),the ICH group(group B),low dose-treated group(group C),moderate dose group(group D) and high dose group(group E). The groups were respectively received an intraperitoneal dexamethasone injection with 1 mg/kg,15 mg/kg,30 mg/kg,twice a day for three days.The brain water content(BWC),the permeability of blood-brain barrier(BBB) and the expression of AQP4 were observed. Results:Both the BBB disruption and AQP4 expression decreased in treated groups,and the AQP4 expression had a dose-dependent manner in the dexamethasone treatment.And it seemed that low dose dexamethasone was in favor of brain swelling elimination,but the higher dosage had not similar effect.Conclusion:Dexamethesone may play a critical role on expression of AQP4 in the physiopathology of hemorrhagic edema. | Jixiang Chen Hui Li | 2007 | Journal of Nanjing Medical University2007，21，5： | 2 |
| 19 | Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription显示文摘Background and Aims:AT-rich interactive domain-containing protein 1A(ARID1A)is frequently mutated or deficient in hepatocellular carcinoma(HCC).However,the role of ARID1A in HCC remains unclear.Therefore,the biological role of ARID1A in HCC was evaluated and a potential mechanism was investigated.Methods:Arid1a was knocked out in the livers of mice using the CRISPR/Cas9 system delivered by hydrodynamic tail vein injection.The development of HCC was observed in different mouse models.The correlation of ARID1A and prognosis in patients with HCC was analyzed using cBioPortal.The effect of ARID1A on cell proliferation was assessed by MTT assay following the manipulation of candidate genes.Results:ARID1A deficiency alone did not cause HCC in mice,but knockout of ARID1A accelerated liver tumorigenesis in response to diethylnitrosamine(DEN)or when a combination knockout of phosphatase and tensin homolog(Pten)plus tumor protein P53(p53)was introduced.ARID1A mutations were associated with a poorer prognosis in HCC patients.The mRNA level of MYC was significantly higher in patients with an ARID1A mutation compared to those without a mutation.Ectopic expression of ARID1A inhibited HCC cell proliferation.ARID1A knockout increased HCC cell growth and resulted in disruptions to DNA damage repair and apoptosis following radiation stress.Furthermore,mechanistic studies revealed that ARID1A inhibited the proliferation of HCC cells via transcriptional down-regulation of MYC.Conclusions:These results describe ARID1A as a tumor suppressor in the liver.A deficiency in ARID1A predicts worse survival in HCC patients and promotes HCC progression via up-regulation of MYC transcription. | Yao Xiao Guodong Liu Xiwu Ouyang Denggao Zai Jixiang Zhou Xiaoli Li Qi Zhang Jie Zhao | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 2 |
| 20 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
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