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| 1 | Helium isotopic compositions in fluid inclusions of the Gangxi fault belt in the Huanghua Depression, Bohai Bay Basin显示文摘The authors obtained 30 core samples from 15 wells in Gangxi fault belt, Huanghua Depression. Using a VG5400 mass spectrometer, the helium isotopic compositions in fluid inclusion of these samples were analysed. Interpreta- tion of results suggests a significant amount of man- tle-derived helium in the inclusions, which were likely trapped during Neocene. Mantle-derived helium have mostly accumulated in the intersections of the NWW trending Xuz- huangzi and NE trending Gangxi faults, and decreased away from the intersections. This pattern implied a close relation- ship to the local tectonic setting. Gangxi fault belt experi- enced intensive neo-tectonic activities in the Cenozoic. Widespread faulted-depressions and strong volcanic erup- tions manifested its tectonic status of extensional stress field. Mantle uplift caused the movement of magma that carried mantle-derived gas, and the deep-rooted tension faults pro- vided the passages for the gases to shallow crust levels. High-content abiogenic CO2 pools occurred in the study area, hence, using the helium isotopic compositions is of great sig- nificance to the exploration of abiogenic natural gases. | DING Weiwei DAI Jinxing YANG Chiyin TAO Shizhen HOU LU | 2005 | Chinese Science Bulletin2005，50，22： | 4 |
| 2 | Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors显示文摘Signal transduction across lipid bilayers is of profound importance in biological processes.In biological systems,natural enzymes mediate biochemical effects by binding to substrates and facilitating the conversion of external signals into physiological responses.Sequential transmission of biological signals from one enzyme to the next promotes signal transduction with feedforward and feedback mechanisms.Reconstructing these processes in an artificial system provides potential applications and offers a new way to understand fundamental biological processes in depth.However,the design of artificial signal transduction systems regulated by artificial enzyme receptors in a predictable and intelligent manner remains a challenge.Herein,benefiting from the polarity-regulated characteristics of Se-containing compounds with artificial glutathione peroxidase(GPx)activity,we constructed an artificial transmembrane signaling receptor with a Se-containing GPx-like recognition head group,a membrane-anchoring group,and a pre-enzyme end group.The artificial supramolecular signal transduction system containing such signal transduction receptors extends the range of signaling systems based on enzyme regulation,which provides a new way to study natural signal processes in cells and artificially regulated biological processes. | Shengda Liu Yunpeng Xing Tengfei Yan Yijia Li Ruizhen Tian Jinxing Hou Jiayun Xu Tingting Wang Junqiu Liu | 2023 | Nano Research2023，16，1： | 0 |
| 3 | Disease X Testing:The results of an international external quality assessment exercise显示文摘The United Nations Secretary-General Mechanism(UNSGM)for investigation of the alleged use of chemical and biological weapons is the only established international mechanism of this type under the UN.The UNGSM may launch an international investigation,relying on a roster of expert consultants,qualified experts,and analytical laboratories nominated by the member states.Under the framework of the UNSGM,we organized an external quality assurance exercise for nominated laboratories,named the Disease X Test,to improve the ability to discover and identify new pathogens that may cause possible epidemics and to determine their animal origin.The“what-if”scenario was to identify the etiological agent responsible for an outbreak that has tested negative for many known pathogens,including viruses and bacteria.Three microbes were added to the samples,Dabie bandavirus,Mammarenavirus,and Gemella spp.,of which the last two have not been taxonomically named or published.The animal samples were from Rattus norvegicus,Marmota himalayana,New Zealand white rabbit,and the tick Haemaphysalis longicornis.Of the 11 international laboratories that participated in this activity,six accurately identified pathogen X as a new Mammarenavirus,and five correctly identified the animal origin as R.norvegicus.These results showed that many laboratories under the UNSGM have the capacity and ability to identify a new virus during a possible international investigation of a suspected biological event.The technical details are discussed in this report. | Tian Qin Han Zheng Xuelian Luo Wen Zhang Jing Yang Yamin Sun Na Han Yuanhai You Liang Lu Xin Lu Di Xiao Shenshen Jiang Xuexin Hou Jinxing Lu Biao Kan Jianzhong Zhang Jianguo | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 0 |
| 4 | Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor显示文摘A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS production.We constructed a telescoped two-step continuous flow platform.This involved a continuous tanshinone IIA sulfonation and in-line salt formation.For the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser micromachining.Compared to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal conditions.The proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production. | Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng Jinxing Ye | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 5 | Trojan nanobacteria hybridized with prodrug nanocapsules for efficient combined tumor therapy显示文摘Live bacteria-based drug delivery systems have been raised as promising tools for enhancing drug delivery into tumors due to their active tumor targeting and easy surface modifiability.In this work,a“Trojan nanobacteria hybrid”,E.coli@highly integrated nanocapsules(HINCs)hybrid(HINE-Hybrid),was successfully constructed with HINCs of prodrug based on covalent selfassembly and the facultative anaerobic bacterium E.coli MG 1655 for combined chemotherapy,photothermal therapy(PTT),and chemodynamic therapy(CDT).HINCs were constructed by covalent cross-linking of pillar[5]arene derivatives and cisplatin prodrug linker,which can be endocytosed and lysed to release therapeutic agents.Under the near-infrared(NIR)light(at 808 nm)irradiation,the system temperature can be significantly increased by HINCs,which further leads to the highly efficient generation of reactive oxygen species(ROS).In addition,HINE-Hybrid shows significant antitumor effects in in vitro and in vivo studies and also promotes immune cell infiltration and antitumor cytokine expression in the tumor microenvironment(TME).HINEHybrid exerts its anticancer properties efficiently due to selective enrichment and multiplication of E.coli at tumor sites,which is important for the construction of bacterial-assisted antitumor platforms. | Mingsong Zang Yuancheng Ji Xiaoran Ding Zhengwei Xu Jinxing Hou Jianxin Sun Jiayun Xu Shuangjiang Yu Hongcheng Sun Tingting Wang Junqiu Liu | 2023 | Nano Research2023，16，7： | 0 |
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