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| 1 | Nature brings new avenues to the therapy of central nervous system diseases——an overview of possible treatments derived from natural products显示文摘Natural products(NPs), including traditional Chinese medicine(TCM), have been long and widely used in the prevention and treatment of central nervous system(CNS) diseases by virtue of their abundant sources, diverse structures, and novel activities.In this review article, we intend to summarize and discuss the situation or status of the clinical employments or trials of the NPs and their derivatives with CNS activities. NPs that have been extensively studied in preclinical research in recent years are also included. The compounds presented in this review are classified according to their indications and followed by details such as natural sources, possible biological mechanisms, and development status, while a considerable proportion of them are found in TCM. In addition, some drug combinations with synergistic effects are also mentioned. According to their impressive therapeutic effects and novel chemical structures, NPs are not only effective therapeutic remedies in clinic, but also lead compounds for structural modification, which indicate that nature brings new avenues to the therapy of CNS diseases. | Junchi Zhang Yang He Xiangrui Jiang Hualiang Jiang Jingshan Shen | 2019 | Science China(Life Sciences)2019，62，10： | 30 |
| 2 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 3 | Parameter determination to calculate water environmental capacity in Zhangweinan Canal Sub-basin in China显示文摘Zhangweinan canal sub-basin (ZWN) has the most serious water resource shortage and water pollution problems in north of China.To calculate the water environmental capacity in ZWN,determination methods for design flow rates and degradation coefficients were discussed in this study.Results showed that 90% and 50% hydrological guarantee flow rates were suitable to be the design flow rates for rainy and dry seasons,respectively.Degradation coefficients of COD Mn and NH 3 -N were 0.25 day -1 and 0.15 day -1 for branch streams and 0.5 day -1 and 0.25 day -1 for mainstreams,respectively in ZWN.With one-dimensional water quality simulation model,water environmental capacities were calculated to be 82,139 tons/yr for COD Mn and 2394 tons/yr for NH 3 -N in ZWN. | Yingxia Li ,Ruzhi Qiu,Zhifeng Yang,Chunhui Li,Jingshan Yu State Key Laboratory of Water Environment Simulation,School of Environment,Beijing Normal University,Beijing,100875,China. | 2010 | Journal of Environmental Sciences2010，22，6： | 23 |
| 4 | 一项有关来那度胺联合低剂量地塞米松治疗中国复发/难治性多发性骨髓瘤患者的多中心、开放性Ⅱ期临床试验:MM-021试验(全译文)显示文摘目的:在中国,复发/难治性多发性骨髓瘤(RRMM)的治疗方案不能满足患者的需求。来那度胺联合低剂量地塞米松可有效治疗白种人RRMM患者,并且通常具备良好的耐受性,但是过去的研究并未评估该疗法对中国RRMM患者的疗效。方法:MM-021是一项多中心、单治疗组、开放性Ⅱ期临床试验,旨在评估来那度胺联合低剂量地塞米松治疗中国RRMM患者的疗效、安全性和药物代谢动力学特征。既往接受过≥1种抗骨髓瘤疗法治疗的患者服用来那度胺+低剂量地塞米松,直至疾病进展或停止用药。存活患者需在入选后接受≥1年的随访。来那度胺剂量为25mg/d,并根据基线肾功能进行调整。大多数受试者均为晚期病患(85.6%为Durie-SalmonⅢ期),并且既往接受过大量治疗(56.7%既往接受过≥4种抗骨髓瘤治疗;69.5%既往接受过沙利度胺治疗;63.1%既往接受过硼替佐米治疗);5.3%患者为免疫球蛋白D型(IgD)。结果:安全性研究群体共有199例入选患者。在疗效研究群体187例患者中,疾病控制率(至少疾病稳定)为94.7%,总缓解率(至少部分缓解)为47.6%,患有肾功能损害及IgD型的患者亦取得高缓解率。至15.2个月中位随访期后,中位缓解持续时间为8.8(0.4-18.8)个月,中位无进展生存期为8.3个月(95%CI6.5-9.8)。最常见3-4级不良事件(AE)为贫血(26.1%)、中性粒细胞减少(25.1%)、血小板减少(14.6%)、肺炎(13.1%)、白细胞减少(9.5%)和中性粒细胞计数减少(8.5%)。AE导致40.2%的患者减少来那度胺剂量和(或)暂停使用,并导致约9.0%的患者停止用药。来那度胺药物代谢动力学特征与白种人和日本患者报道的结果相似。结论:既往接受过多次治疗的中国RRMM患者(包括肾功能损害和IgD亚型患者)对来那度胺联合低剂量地塞米松治疗方案具有可接受的安全性和高缓解率。这些研究发现显示了此治疗方案对于目前治疗方案均无效的中国RRMM患者具有临床应用潜力。 | 侯健 杜欣 金洁 蔡真 陈方平 周道斌 于力 克晓燕 李晓 吴德沛 孟凡义 艾辉胜 Jingshan Zhang Honeylet Wortman-Vayn Nianhang Chen Jay Mei 王健民 | 2014 | 临床血液学杂志2014，27，5： | 18 |
| 5 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 6 | Combined human growth hormone and lactulose for prevention and treatment of multiple organ dysfunction in patients with severe chronic hepatitis B显示文摘AIM: To evaluate the efficiency and safety of combined recombinant human growth hormone (rhGH) and lactulose for treatment and/or prevention of multiple organ dysfunction in patients with chronic severe hepatitis B. METHODS: Forty-eight inpatients with chronic severe hepatitis B were randomly divided into rhGH group (n = 28)and control group (n = 20). In rhGH group, 4-4.5 IU of rhGH was injected intramuscularly once daily for 2-4 wk,and 100 mL of enema containing 30 mL of lactulose, 2 g of metronidazole and 0.9% saline was administered every 2 d for 2-4 wk. Their symptoms and complications were noted. Liver and kidney functions were analyzed by an Olympus analyzer. Serum GH, IGF-1, IGFBP1 and IGFBP3 were measured by ELISA.RESULTS: Clinical symptoms of 90% of these patients in rhGH group were obviously improved. The total effectiveness in rhGH group was better than that in control group (75% vs40%, P<0.05). After 2- and 4-wk treatment of rhGH respectively, serum albumin (26.1±4.1 vs 30.2±5.3,31.9±5.1 g/L), prealbumin (79.6±28.0 vs 106.6±54.4,108.4±55.0 g/L), cholesterol (76.3±16.7 vs 85.6±32.3,96.1±38.7 mg/dL), and IGFBP1 (56.8±47.2 vs 89.7±50.3ng/mL after 2 wk) were significantly increased compared to control group (P<0.05). However, serum GH was decreased. The increase of serum IGF1 and IGFBP3 after rhGH treatment was also observed.CONCLUSION: rhGH in combination with lactulose may be beneficial to the prevention and treatment of multiple organ dysfunction in patients with chronic severe hepatitis. | Hui-GuoDing JingShan BinZhang Hong-BoMa LiZhou RuiJin Yu-FenTan Li-XiangHe | 2005 | World Journal of Gastroenterology2005，11，19： | 13 |
| 7 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 8 | Therapeutic evaluation of lumbar tender point deep massage for chronic non-specific low back pain显示文摘OBJECTIVE:To observe the therapeutic effect of lumbar tender point deep tissue massage plus lumbar traction on chronic non-specific low back pain using change in pressure pain threshold,muscle hardness and pain intensity as indices.METHODS:We randomly divided 64 patients into a treatment group(32 cases) and a control group(32 cases).Two drop-outs occurred in each group.Patients in the treatment group received tender point deep tissue massage plus lumbar traction and patients in the control group received lumbar traction,alone.We used a tissue hardness meter/algometer and visual analog scale(VAS) to assess the pressure pain threshold,muscle hardness and pain intensity.RESULTS:Following treatment,we obtained the following results in the treatment and control groups,respectively:the pressure pain threshold difference was 1.5±0.8 and 1.1±0.7;the muscle hardness difference was 4.2±1.6 and 3.5±1.3;and the VAS score difference was 1.9±0.9 and 1.4±0.8.Compared to the control group,the treatment group had higher pressure pain threshold(t=2.09,P<0.05),and lower muscle hardness(t=2.05,P<0.05) and pain intensity(t=2.46,P<0.05).CONCLUSION:Lumbar tender point deep tissue massage combined with lumbar traction produced better improvement in pressure pain threshold,muscle hardness and pain intensity in patients with chronic non-specific low back pain than with lumbar traction alone. | Zhixin Zheng Jun Wang Qian Gao Jingshan Hou Ling Ma Congbo Jiang Guohui Chen | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 10 |
| 9 | Simulations on the influence of lunar surface temperature profiles on CE-1 lunar microwave sounder brightness temperature显示文摘Surface temperature profile is an important parameter in lunar microwave remote sensing. Based on the analysis of physical properties of the lunar samples brought back by the Apollo and Luna missions, we modeled temporal and spatial variation of lunar surface temperature with the heat conduction equation, and produced temperature distribution in top 6.0 m of lunar regolith of the whole Moon surface. Our simulation results show that the profile of lunar surface temperature varies mainly within the top 20 cm, except at the lunar polar regions where the changes can reach to about 1.0 m depth. The temperature is stable beyond that depth. The variations of lunar surface temperature lead to main changes in brightness temperature (TB) at different channels of the lunar microwave sounder (CELMS) on Chang'E-1 (CE-1). The results of this paper show that the temperature profile influenced CELMS TB, which provides strong validation on the CELMS data, and lays a solid basis for future interpretation and utilization of the CELMS data. | LI Yun WANG ZhenZhan JIANG JingShan | 2010 | Science China Earth Sciences2010，53，9： | 8 |
| 10 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 11 | A constitutive model for the state-dependent behaviors of rockfill material considering particle breakage显示文摘The particle breakage during specimen compaction had more significant influence on the position of the breakage critical-state line(BCSL)of Tacheng rockfill material(TRM)in the e-lnp’plane than the particle breakage during shearing,based on the large-scale triaxial compression tests on TRM in a wide range of densities and pressures.The state-dependent dilatancy and the plastic modulus were correlated to the breakage index,based on the formulations of the BCSL of TRM in the e-lnp’plane.The state-dependent model considering particle breakage was proposed for TRM within the framework of the generalized plasticity theory.The proposed model contained fourteen material constants.The test data of TRM from Group A were adopted to determine these material constants,while the test data from Group B were used independently to validate the model predictive capacity.The comparisons between model simulations and test data illustrated that the model with consideration of particle breakage could well represent the stress-strain behaviors of TRM,e.g.,the strain hardening and volumetric contraction behaviors at a loose state and the strain softening and volumetric expansion behaviors at a dense state,and also the particle breakage behaviors of TRM. | XIAO Yang LIU HanLong YANG Gui CHEN YuMin JIANG JingShan | 2014 | Science China(Technological Sciences)2014，57，8： | 6 |
| 12 | Effects of stick-slip on stress intensity factors for subsurface short cracks in rolling contact显示文摘This paper theoretically investigates the effects of stick-slip in rolling contact zone on stress intensity factors(SIFs)for subsurface short cracks.New mathematical models for SIFs including stick-slip ratio are deduced in two cases.One is a subsurface short crack parallel to surface,and the numerical analysis shows that the value of KⅡincreases with the increase of stick-slip ratio;the other is a subsurface short crack perpendicular to the surface,and the numerical analysis indicates that the positive value of KⅠdecreases with the increase of stick-slip ratio.As △KⅠand △KⅡare necessary to evaluate the fatigue crack propagation rate or fatigue lifetime,the influences of stick-slip ratio on them are then discussed.It is found that the maximum variations of △KⅠand △KⅡare both around 3.0%due to stick-slip ratio variation. | LIU WenTao ZHANG Yun FENG ZhiJing ZHAO JingShan | 2013 | Science China(Technological Sciences)2013，56，10： | 6 |
| 13 | Microstructure and performance of dissimilar joint QCr0.8/TC4 welded by uncentered electron beam显示文摘The mechanical property of dissimilar metal joint between QCr0.8 and TC4 alloy made with centered electron beam is bad and the highest tensile strength of the joint is only about 82.1 MPa.The bad mechanical property is mainly caused by the asymmetric fusion of the two base metals and the generation of the brittle Ti-Cu intermetallic compounds.The finite element analysis shows that the amount of the melted QCr0.8 copper alloy can be added to reduce the amount of the brittle intermetallic compounds.The bias distance to the copper alloy hc has obvious effect on the tensile strength.When hc=0.8 mm,the tensile strength of the joint can reach 270.5 MPa.The reaction layer near the fusion line on the TC4 side consists of the intermetallic compound and the melted base metal which does not react.The joint fractures at the reaction layer and presents quasi-cleavage or transcrystalline rupture in tensile tests. | LIU Wei,ZHANG Binggang,HE Jingshan and ZHAO Haisheng State Key Laboratory of Advanced Welding Production Technology,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 5 |
| 14 | Calibration and brightness temperature algorithm of CE-1 Lunar Microwave Sounder (CELMS)显示文摘CE-1 Lunar Microwave Sounder (CELMS) is the first passive microwave radiometer in the world to sound the surface of the Moon in the lunar orbit at altitude of 200 km. The scientific objective of CELMS is to obtain global brightness temperature (TB) of the Moon, to retrieve information on lunar regolith, and to evaluate the distribution of helium-3 on the Moon implanted by solar wind. Before launch of CELMS, a series of experiments were carried out in laboratories to test the performances of the systems, and to calibrate the responses between the input of TB and the output of voltage from the receivers. However, the thermal condition exposed to CELMS is more complicated in lunar orbit than on the Earth, which makes the temperatures of different parts of CELMS wave vary greatly, and the cosmic background is not very clean due to the pointing of cold space antenna to the direction of the satellite running, which brings uncertainties into data-processing of CELMS when the temperature of cold space is used as a calibrator. Furthermore, the lack of knowledge on the lunar ingredients and compositions, distributions of physical temperatures, and properties on lunar microwave radiation leads to difficulties in validating the measurements and retrievals of CELMS. By analyzing the results of ground experiments and the measurements of CELMS in-orbit, along with our knowledge of the properties of lunar surface, here we give algorithms on calibration and antenna pattern correction (APC) of CELMS. We also describe in detail the principle of microwave transfer among the elements of CELMS, and discuss the method on testing calibration parameters of the system. In addition, the theory and model on correction antenna pattern of CELMS are developed by comparing antenna temperatures by CELMS with those simulated by microwave radiative transfer models. The global distribution of TB is given and the features of TB are analyzed. Our results show rich information included in TB on the properties of lunar regolith, especially the thickness and dielectric constant, which are nearly directly reflected by the differences of TB at day and those at night. | ZhenZhan Wang Yun Li XiaoHui Zhang Jiang JingShan ChuanDong Xu DeHai Zhang WeiGuo Zhang | 2010 | Science China Earth Sciences2010，53，9： | 5 |
| 15 | Site amplification effects as an explanation for the intensity anomaly in the Hanyuan Town during the Wenchuan Mw 7.9 earthquake显示文摘The Hanyuan Town is located approximately 200 km from the macro-epicenter of the great Wenchuan earthquake. However, it is within the only Intensity Ⅷ zone, surrounded by a region of Intensity Ⅵ. The objective of this study was to investigate this high-intensity anomaly with respect to the site amplifications in the Hanyuan Town. The base inputs were derived from the records at a nearby strong-motion station because no records were available from the town. The characteristics of the subsurface formations and their dynamic properties at a typical site in the town were obtained by drilling, field tests and laboratory tests. Seismic response and parametric sensitivity analyses of the site were conducted using Shake 91, and the results were compared with the provisions for rare earthquakes from the Chinese Code for Seismic Design of Buildings(GBJ11-89). The results showed that the average peak acceleration at the site during the Wenchuan earthquake is similar to the code-specified value under rare earthquakes, that the corresponding spectral accelerations for periods between approximately 0.35 and 0.75 s are significantly stronger than those specified by the code and that the average amplification factor at the site is significantly higher than the mean value of the site class. These findings indicate that the high-intensity anomaly in the town was primarily caused by site amplification effects from the unique structure of the soil strata. | Liu Hongshuai Bo Jingshan Li Ping QiWenhao Zhang Yudong | 2016 | Earthquake Engineering and Engineering Vibration2016，15，3： | 4 |
| 16 | Chemically tailored molecular surface modifiers for efficient and stable perovskite photovoltaics显示文摘Perovskite solar cells(PSCs)have attracted intense attention based on their high power conversion efficiency and low production cost.However,due to the polycrystalline nature and the intrinsic hydrophilicity of the metal halide perovskite moieties,the photovoltaic performance of PSCs is largely limited by defects within the polycrystalline perovskites and the sensitivity to moisture.In this perspective,we focus on the chemically tailored interface materials to passivate the defects and improve the moisture stability of PSCs.First,we provide a brief overview of various molecular interface modifiers.Thereafter we provide examples from our recent work on organic ammonium halide‐based passivation materials as representatives to illustrate the design strategies and the modification effects.In the end,we shed light on the future devel-opment of organic ammonium halides for applications in PSCs. | Yuhang Liu Bitao Dong Anders Hagfeldt Jingshan Luo Michael Graetzel | 2021 | SmartMat2021，2，1： | 4 |
| 17 | Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir,Its Parent Nucleoside and β-D-N^(4)-hydroxycytidine显示文摘Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is widespread in the world.In recent years,the increased virulence of the virus due to viral variations,has caused great economic losses to the pig industry in many countries.It is always worthy to find effective therapeutic methods for PED.As an important class of antivirals,nucleoside drugs which target viral polymerases have been applied in treating human viral infections for half a century.Herein,we evaluated the anti-PEDV potential of three broad-spectrum antiviral nucleoside analogs,remdesivir(RDV),its parent nucleoside(RDV-N)andβ-D-N^(4)-hydroxycytidine(NHC).Among them,RDV-N was the most active agent in Vero E6 cells with EC_(50) of 0.31μmol/L,and more potent than RDV(EC_(50)=0.74μmol/L)and NHC(EC_(50)=1.17μmol/L).The activity of RDV-N was further confirmed using an indirect immuno-fluorescence assay.Moreover,RDV-N exhibited a good safety profile in cells and in mice.The high sequence similarity of the polymerase functional domains of PEDV with other five porcine coronaviruses indicated a broader antiviral spectrum for the three compounds.Generally,RDV-N is a promising broad-spectrum antiviral nucleoside,and it would be worthy to make some structural modifications to increse its oral bioavailability. | Yuanchao Xie Xiaozhen Guo Tianwen Hu Daibao Wei Xiuli Ma Jiaqiang Wu Bing Huang Jingshan Shen | 2021 | Virologica Sinica2021，36，5： | 3 |
| 18 | Investigation of anaplasmosis in Yiyuan County,Shandong Province,China显示文摘Objective:To investigate the situation of anaplasmosis in Yiyuan county.Shandong Province. Methods:A total of 26 blood samples from febrile patients suspected of anaplasmosis,48 blood samples from healthy farmers,8 from dogs,and 10 from goats and 170 ticks were collected in the same area during 2005-2007,and detected by serological and molecular methods.Results: Eight confirmed cases and 6 probable cases were determined using serologic and molecular methods.The seroprevalence of Anaplasma phagocytophilum(A.phagocytophilum) was 26.7% in healthy cases.Nine out of 10 sheep samples and 7 out of 8 dog samples reacted positively to the A.phagocytophilum antigen.PCR amplification and sequencing of the 16SrRNA of,4. phagocytophilum gene showed that some samples from patients,goats and ticks were 100% identical.The seroprevalence of Rickettsia typhi was 22.9%,Orientia tsutsugamushi 6.3%, Rickettsia sibirica 27.1%,Coxiella burnetii 18.8%,Bartonella henselae 31.3%,and Borrelia burgdorferi 41.6%.Conclusions:It is important to make differential diagnosis of febrile patients and to apply treatment with specific antibiotics.It is needed to enforce essential prevention and control measures including tick control and to improve sanitation conditions. | Lijuan Zhang Feng Cui Lingling Wang Lingling Zhang Jingshan Zhang Shiwen Wang Shuxia Yang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 3 |
| 19 | Distribution and anomaly of microwave emission at Lunar South Pole显示文摘Investigation on Lunar polar area is almost every lunar mission’s primary objective in recent years. The rationale behind it is that illumination and ice resources in this area can be potentially very helpful for constructing lunar human base. In this paper, we analyze microwave radiometric characteristics of the Moon by using the newly acquired Chang’E-1 Lunar Microwave Sounder (CELMS) data. Microwave brightness temperature at Lunar South Pole (LSP) is distributed regularly with a style of 'ring-in-ring', decreasing from equator to pole. Regolith temperature gradient is bigger at lunar equator than at polar area. Brightness temperature diurnal difference decreases with observation frequency. Microwave brightness temperature distribution maps at LSP and Lunar North Pole (LNP) have been made based on the analysis. It is found that microwave brightness temperature becomes to synchronize with elevation beyond -85° latitude. This phenomenon is related to lightening condition and indicates temperature distribution at LSP. The brightness temperature anomaly cold points are potentially cold trap areas for water or ice while hot points imply plenty of illumination resources there. | WeiGuo Zhang JingShan Jiang HeGuang Liu XiaoHui Zhang DeHai Zhang DiHui Li ChuanDong Xu | 2010 | Science China Earth Sciences2010，53，3： | 3 |
| 20 | Microstructure characterization of electron beam welded joints of Ti_3Al after post-weld heat treatment显示文摘The effect of post-weld heat treatment on the microstructure characterization of electron beam welded(EBW) joints of Ti3Al-Nb was investigated.The results show that the microstructure of the weld is predominantly metastable,the columnar crystal metastructure of B2 phase.The microstructure morphology of the weld is significantly influenced by the method of the heat treatment.The microstructure of the weld is laminar structure(Widmanstaten structure) consisted of interphase α2 and B2 after post-weld heat treatment of 1000 ℃/2 h.The mechanism of the post-weld heat treatment makes the hardness distribution of joints homogeneous,but makes the whole joint somehow softened. | HE Jingshan,WU Qingsheng,ZHANG Binggang,LIU Wei,and FENG Jicai State Key Laboratory of Advanced Welding Production Technology,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 3 |
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