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| 1 | Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier显示文摘Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients' 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis. | QU AiPing CHEN JiaMei WANG LinWei YUAN JingPing YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan | 2015 | Science China(Information Sciences)2015，58，9： | 12 |
| 2 | Object-based image analysis for mapping geomorphic zones of coral reefs in the Xisha Islands, China显示文摘Mapping regional spatial patterns of coral reef geomorphology provides the primary information to understand the constructive processes in the reef ecosystem. However, this work is challenged by the pixel-based image classification method for its comparatively low accuracy. In this paper, an object-based image analysis(OBIA)method was presented to map intra-reef geomorphology of coral reefs in the Xisha Islands, China using Landsat 8satellite imagery. Following the work of the Millennium Coral Reef Mapping Project, a regional reef class hierarchy with ten geomorphic classes was first defined. Then, incorporating the hierarchical concept and integrating the spectral and additional spatial information such as context, shape and contextual relationships, a large-scale geomorphic map was produced by OBIA with accuracies generally more than 80%. Although the robustness of OBIA has been validated in the applications of coral reef mapping from individual reefs to reef system in this paper, further work is still required to improve its transferability. | XU Jingping ZHAO Jianhua LI Fang WANG Lin SONG Derui WEN Shiyong WANG Fei GAO Ning | 2016 | Acta Oceanologica Sinica2016，35，12： | 7 |
| 3 | Atypical features and treatment choices in bipolar disorders:a result of the National Bipolar Mania Pathway Survey in China显示文摘In this study,we examined the point prevalence rate of atypical features in bipolar disorder,and estimated the potential impact of these features on treatment practices in China. Using the atypical features criteria of the Diagnostic and Statistical Manual of the American Psychiatric Association(DSM-IV),we documented the atypical symptoms in 3 906 consecutive participants with bipolar disorder enrolled at 26 psychiatric services across China. We further assessed the association between atypical features and the treatment approaches,including the prescription of antidepressants. The overall point prevalence rate of atypical features was 9.1% among patients with various bipolar disorder subtypes. When the definition was broadened to include atypical features B,the overall rate increased to 11.8%. Interestingly,among patients with the mixed state and remission subtypes,there was a significant difference in the rates of antidepressant medication usage between patients who met and those who did not meet the criteria for atypical features B. These fi ndings indicate a trend of using antidepressants for these two types of patients with atypical features. Further,for both mixed state and remission patients,treatment approaches were related to atypicalfeatures B. Our findings provide evidence to assist clinicians to readily recognize atypical features in bipolar subtypes and can propose treatments based on these diagnoses. | Daihui Peng Ting Shen Linda Byrne Chen Zhang Yueqi Huang Xin Yu Jingping Zhao Marita McCabe David Mellor Yiru Fang | 2015 | Neuroscience Bulletin2015，31，1： | 4 |
| 4 | Spatio-temporal Change and Carrying Capacity Evaluation of Human Coastal Utilization in Liaodong Bay,China from 1993 to 2015显示文摘In China, promoting the development of coastal areas has been included in a series of national strategic development plans.At the same time, many marine environmental problems have been associated with the rapid development of coastal sea use. In order to quantify the impact of human activities on the coast, the characteristics of coastlines and near-shore sea use of Liaodong Bay, Northeast China, were first classified using multi-source, remotely sensed imagery using automatic or semi-automatic extraction methods for five periods between 1993 and 2015. Sea use dynamics and coastline dynamics resulting from human activates were analyzed. Results showed a significant trend of continuous growth in sea use and a progressive increase in the total length of artificial coastline, but a noticeable loss of natural coastline during the five periods. Reclaimed land and enclosed areas were the main types of sea use. Most coastal human activities were distributed in the northern part of the bay. In recent years, rapid industrialization and urbanization in China's coastal areas have promoted large-scale land reclamation. Accordingly, the observed coastline changes during each period had a close relationship with coastal development and sea area utilization. Based on marine functional zoning(MFZ), the sea use carrying capacity was evaluated by means of indexes to describe human exploitation of the marine and coastal environments in the bay. This showed that the intensity of coastal utilization in Liaodong Bay has increased year-on-year. Sea use carrying capacity reached a ‘critically loaded'state by 2008 and was ‘overloaded' by 2015. | XU Jingping LI Fang SUO Anning ZHAO Jianhua SU Xiu | 2019 | Chinese Geographical Science2019，29，3： | 2 |
| 5 | A New Family of Ce6MoO15 as Fast Oxide Ion Conductor显示文摘A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the conductivity further, and have high oxide-ion conductivity, which may be a kind of promising material for SOFCs. | Feng Jing Bo Qibing Che Ping Wang Jingping Liu Jianfen Lu Minfeng Zhang Deping Fang Daqing Cao Xueqiang Meng Jian | 2004 | Journal of Rare Earths2004，22，z2： | 2 |
| 6 | Retrieval of Total Suspended Matters Using Field Spectral Data in Shitoukoumen Reservoir,Jilin Province,Northeast China显示文摘From August to October in 2006,three times of field spectral measurements with a Field Spec FR spectroradiometer(Analytical Spectral Devices,Inc.,USA) were carried out in Shitoukoumen Reservoir,Jilin Province,Northeast China. Owing to the serious soil and water loss in the upstream,reflectance curves of the reservoir were characterized by high concentrations of total suspended matter(TSM) . Extending the spectral analysis to 1200nm in the near-infrared band,this research revealed an obvious reflectance peak around 1070nm which was caused by the strong backscattering of high TSM. The method of partial least squares(PLS) regression was applied to retrieving the TSM. Reflectance in two spectral bands,i.e.,675-948nm and 1029-1105nm,were used as variables to develop PLS models. Traditional linear regression,first derivative model and logarithmic model were also used for the comparison of different models. Results showed that the PLS model based on Rrs(675) -Rrs(948) gave out best results with high precision and stability. Although the PLS model based on Rrs(1029) -Rrs(1105) did not have an outstanding performance due to lots of noise,the reflectance peak in the near-infrared band was an important TSM feature and its efficient exploitation would have a considerable significance in TSM remote sensing. | XU Jingping ZHANG Bai LI Fang SONG Kaishan WANG Zongming LIU Dianwei ZHANG Guangxin | 2009 | Chinese Geographical Science2009，19，1： | 2 |
| 7 | Effects of the crystallization time on the mesoporous structure,texture, morphology and styrene oxidation performances of V-MCM-41显示文摘The new V-MCM-41 molecular sieves with good ordered hexagonal mesoporous structure and crystallinity were synthesized through in-situ hydrothermal preparation method. The effects of the crystallization time were discussed. The synthesized samples were characterized by X-ray diffraction, N2adsorption/desorption, Fourier transformed infrared and scanning electron microscopy. The different structures, textures, morphologies of V-MCM-41 obtained with different crystallization times were observed and analyzed on the basis of the characterized results. The results showed that the V-MCM-41 molecular sieve obtained at 110 °C for 48 h crystallization times was of good spherical morphology, ordered hexagonal structure, most uniform pore size distribution and high surface area compared with other samples. Meanwhile, the V-MCM-41 molecular sieve with the high skeleton Si condensation and the good crystallinity was obtained. The heteroatom could be incorporated into MCM-41 framework with increasing crystallization times, which was beneficial to improve the catalytic activity and selectivity of pure siliceous MCM-41. The V-MCM-41 showed the good catalytic selectivity in catalytic oxidation of styrene using hydrogen peroxide, and the selectivity of the benzaldehyde and phenylacetic acid reached 30.68%and 49.44%, respectively. | Junqiang Xu Qiang Zhang Fang Guo Jingping Hong Wei Chu | 2016 | Journal of Energy Chemistry2016，25，6： | 2 |
| 8 | GPS Meteorology: Direct Estimation of the Absolute Value of Precipitable Water Vapor 显示文摘 | DUAN Jingping BEVIS M FANG Peng | 1996 | Journal of Applied Meteorology1996，35，： | 1 |
| 9 | GPS meteorology: Direct estimation of the absolute value of precipitable water显示文摘 | Duan Jingping Bevis M Fang Peng | 1996 | J Appl Meteor1996，35，： | 1 |
| 10 | Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts显示文摘 | Fang Li Zhimin He Jingping Shen Qian Huang Wenrong Li Xinjian Liu Yujun He Frank Wolf Chuan-Yuan Li | 2010 | Cell Stem Cell2010，，4： | 1 |
| 11 | GPS meteorology:direct estimation of the absolute value of precipitable water显示文摘 | DUAN Jingping BEVISA M FANG Peng | 1996 | Journal of Applied Meteorology1996，35，6： | 1 |
| 12 | High charge/discharge rate polypyrrole films prepared by pulse current polymerization 显示文摘 | Wang Jingping Xu Youlong Wang Jie Xiao Fang | 2010 | Synthetic Metals2010，160，1718： | 1 |
| 13 | Hydrothermal synthesis and crystal structure of a new two-dimensional zinc cit- ratecomplex 显示文摘 | PING CHE DAQING FANG DEPING ZHANG JING FENG JINGPING WANG NINGHAI HU and JIAN MENG | 2005 | Joumal of Coordinatian Chemistry2005，，： | 1 |
| 14 | Plasma jet imaging by CCD technology in rapid mold manufacturing显示文摘 | Xu Jingping Fang Jiancheng Li Zhigang | 2002 | Journal of Materials Processing Technology2002，129，： | 1 |
| 15 | Effects of MicroRNA - 29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma 显示文摘 | Yujuan Xiong Jianhong Fang Jingping Yun | 2010 | Hepatology2010，51，3： | 1 |
| 16 | Evolutionary genomics of structural variation in the tea plant,Camellia sinensis显示文摘Structural variants(SVs)are a type of genetic variation that contribute substantially to phenotypic diversity and evolution.Further study of SVs will help us understand the influence of SVs associated with tea quality and stress resistance and provide new insight into tea plant breeding improvement and genetic research.However,SVs have not been thoroughly discovered in the tea plant genomes.Herein,we constructed a large-scale SV map across a population of 107 resequenced genomes,including both ancient and cultivated tea plants.A total of 44,240 highconfident SVs were identified,including 34,124 DEL(deletions),4,448 DUP(duplications),2,503 INV(inversions),544 INS(insertions)and 2,621 TRA(translocations).In total,12,400 protein-coding genes were overlapped with SVs,of which 49.5%were expressed in all five tea tissues.SVbased analysis of phylogenetic relationships and population structure in tea plants showed a consistent evolutionary history with the SNP-based results.We also identified SVs subject to artificial selection and found that genes under domestication were enriched in metabolic pathways involving theanine and purine alkaloids,biosynthesis of monoterpenoid,phenylpropanoid,fatty acid,and isoflavonoid,contributing to traits of agronomic interest in tea plants.In addition,a total of 27 terpene synthase(TPS)family genes were selected during domestication.These results indicate that these SVs could provide extensive genomic information for tea quality improvement. | Shuai Chen Jingping Fang Yibin Wang Pengjie Wang Shengcheng Zhang Zhenyang Liao Hong Lu Xingtan Zhang | 2022 | Tropical Plants2022，1，1： | 0 |
| 17 | Multi-omics Analyses Provide Insight into the Biosynthesis Pathways of Fucoxanthin in Isochrysis galbana显示文摘Isochrysis galbana is considered an ideal bait for functional foods and nutraceuticals of humans because of its high fucoxanthin(Fx)content.However,multi-omics analysis of the regulatory networks for Fx biosynthesis in I.galbana has not been reported.In this study,we report a high-quality genome assembly of I.galbana LG007,which has a genome size of 92.73 Mb,with a contig N50 of 6.99 Mb and 14,900 protein-coding genes.Phylogenetic analysis confirmed the monophyly of Haptophyta,with I.galbana sister to Emiliania huxleyi and Chrysochromulina tobinii.Evolutionary analysis revealed an estimated divergence time between I.galbana and E.huxleyi of~133 million years ago.Gene family analysis indicated that lipid metabolism-related genes exhibited significant expansion,including IgPLMT,IgOAR1,and IgDEGS1.Metabolome analysis showed that the content of carotenoids in I.galbana cultured under green light for 7 days was higher than that under white light,andβ-carotene was the main carotenoid,accounting for 79.09%of the total carotenoids.Comprehensive multi-omics analysis revealed that the content ofβ-carotene,antheraxanthin,zeaxanthin,and Fx was increased by green light induction,which was significantly correlated with the expression of IgMYB98,IgZDS,IgPDS,IgLHCX2,IgZEP,IgLCYb,and IgNSY.These findings contribute to the understanding of Fx biosynthesis and its regulation,providing a valuable reference for food and pharmaceutical applications. | Duo Chen Xue Yuan Xuehai Zheng Jingping Fang Gang Lin Rongmao Li Jiannan Chen Wenjin He Zhen Huang Wenfang Fan Limin Liang Chentao Lin Jinmao Zhu Youqiang Chen Ting Xue | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 0 |
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