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| 1 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 2 | Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction显示文摘Myocardial infarction(MI)is one of cardiovascular diseases that pose a serious threat to human health.The pathophysiology of MI is complex and contains several sequential phases including blockage of a coronary artery,necrosis of myocardial cells,inflammation,and myocardial fibrosis.Aiming at the treatment of different stages of MI,in this work,an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor(VEGF)and silk fibroin(SF)microspheres containing bone morphogenetic protein 9(BMP9)for releasing VEGF and BMP9 to realize their respective functions.The results of in vitro experiments indicate a rapid initial release of VEGF during the first few days and a relatively slow and sustained release of BMP9 for days,facilitating the formation of blood vessels in the early stage and inhibiting myocardial fibrosis in the long-term stage,respectively.Intramyocardial injection of such composite hydrogel into the infarct border zone of mice MI model via multiple points promotes angiogenesis and reduces the infarction size.Taken together,these results indicate that the dual-release of VEGF and BMP9 from the composite hydrogel results in a collaborative effect on the treatment of MI and improvement of heart function,showing a promising potential for cardiac clinical application. | Yong Wu Tianqi Chang Weiqian Chen Xiaoyu Wang Jingjing Li Yueqiu Chen You Yu Zhenya Shen Qian Yu Yanxia Zhang | 2021 | Bioactive Materials2021，6，2： | 7 |
| 3 | Histone Deacetylase HDA9 and WRKY53 Transcription Factor Are Mutual Antagonists in Regulation of Plant Stress Response显示文摘Epigenetic regulation of gene expression is important for plant adaptation to environm ental changes.Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is known to function in repressing plant response to stress in Arabidopsis.However,how HDA9 targets to specific chromatin loci and controls gene expression netw orks involved in plant response to stress remains largely unclear.Here,we show that HDA9 represses stress tolerance response by interacting with and regulating the DNA binding and transcriptional activity of WRKY53,which functions as a high-hierarchy positive regulator of stress response.We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites,some of which are removed by HDA9,resulting in inhibition of WRKY53 transcription activity.Conversely,WRKY53 negatively regulates HDA9 histone deacetylase activity.Collectively,our results indicate that HDA9 and WRK53 are reciprocal negative regulators of each other's activities,illustrating how the functional interplay between a chromatin regulator and a transcription factor regulates stress tolerance in plants. | Yu Zheng Jingyu Ge Chun Bao Wenwen Chang Jingjing Liu Jingjie Shao Xiaoyun Liu Lufang Su Lei Pan Dao-Xiu Zhou | 2020 | Molecular Plant2020，13，4： | 6 |
| 4 | Triboelectrification induced UV emission from plasmon discharge显示文摘紫外有的高精力的电磁的放射广泛地在工业生产和科学研究领域被使用。在这个工作,深紫外的轻排出物用 triboelectrification 被获得没有任何额外的电源供应的导致的血浆分泌物。由在聚合物和石英玻璃之间的机械磨擦,摩擦电费用引起一个变化电场,它可以带低压力气体(Ar-Hg ) 的血浆分泌物并且给出 253.7 nm 照耀。连续磨擦引起的紫外光能使三色的黄磷激动并且负担得起明亮白的轻排出物。一个紫外消毒实验证明 98% Escherichia coli 能被紫外照耀在 30 min 打死,它表明有好消毒效果的一台自我动力的消毒仪器被制作。这个工作提供一个新奇图案用低频率的机械磨擦制作一台自我动力的紫外轻射出设备并且认识到联合 triboelectrification 和血浆光,它可以进一步在特殊情形扩展紫外光的申请。 | Chang Bao Han Chi Zhang Jingjing Tian Xiaohui Li Limin Zhang Zhou Li Zhong Lin Wang | 2015 | Nano Research2015，8，1： | 5 |
| 5 | Methyl jasmonate mediates melatonin-induced cold tolerance of grafted watermelon plants显示文摘Root–shoot communication has a critical role in plant adaptation to environmental stress.Grafting is widely applied to enhance the abiotic stress tolerance of many horticultural crop species;however,the signal transduction mechanism involved in this tolerance remains unknown.Here,we show that pumpkin-or figleaf gourd rootstock-enhanced cold tolerance of watermelon shoots is accompanied by increases in the accumulation of melatonin,methyl jasmonate(MeJA),and hydrogen peroxide(H_(2)O_(2)).Increased melatonin levels in leaves were associated with both increased melatonin in rootstocks and MeJA-induced melatonin biosynthesis in leaves of plants under cold stress.Exogenous melatonin increased the accumulation of MeJA and H_(2)O_(2) and enhanced cold tolerance,while inhibition of melatonin accumulation attenuated rootstock-induced MeJA and H_(2)O_(2) accumulation and cold tolerance.MeJA application induced H_(2)O_(2) accumulation and cold tolerance,but inhibition of JA biosynthesis abolished rootstock-or melatonin-induced H_(2)O_(2) accumulation and cold tolerance.Additionally,inhibition of H_(2)O_(2) production attenuated MeJA-induced tolerance to cold stress.Taken together,our results suggest that melatonin is involved in grafting-induced cold tolerance by inducing the accumulation of MeJA and H_(2)O_(2).MeJA subsequently increases melatonin accumulation,forming a self-amplifying feedback loop that leads to increased H_(2)O_(2) accumulation and cold tolerance.This study reveals a novel regulatory mechanism of rootstock-induced cold tolerance. | Hao Li Yanliang Guo Zhixiang Lan Kai Xu Jingjing Chang Golam Jalal Ahammed Jianxiang Ma Chunhua Wei Xian Zhang | 2021 | Horticulture Research2021，8，1： | 5 |
| 6 | BKI1 Regulates Plant Architecture through Coordinated Inhibition of the Brassinosteroid and ERECTA Signaling Pathways in Arabidopsis显示文摘几百次充满白氨酸的重复像受体的 kinases (LRR-RLKs ) 玩在大量植物的不可缺少的角色发展、生理的过程。在基础、不活跃的地位控制 LRR-RLKs 的机制必要却很少学习。BKI1 是唯一的在 Arabidopsis 报导了受体 kinases 的禁止者,它否定地在 brassinosteroid 小径调整 BRI1。在这研究,我们发现 BKI1 能也与另一重要 LRR-RLK 交往, ERECTA (嗯) 。Phenotypic 分析显示出那 BKI1,包括花梗取向并且嗯一起调整植物建筑学,它是最新报导的显型在调停 BR 并且嗯调停发展进程。基因表示分析表明 BKI1 调整嗯应答的基因的一个子集。Kinase 试金证明 BKI1 禁止嗯 kinase 活动。另外, BKI1 抑制在上的版本嗯发信号主要依靠 BRI1 激活。我们的数据提供重要卓见进 RLK 的规定和激活并且建议 BKI1 作为 BRI1 的普通 suppressor 工作并且嗯发信号的小径。 | Dongxu Wang Cangjing Yang Haijiao Wang Zhihua Wu Jianjun Jiang Jingjing Liu Zhuona He Fang Chang Hong Ma Xuelu Wang | 2017 | Molecular Plant2017，10，2： | 5 |
| 7 | Memory stem T cells generated by Wnt signaling from blood of human renal clear cell carcinoma patients显示文摘Objective: Memory stem T cells(Tscm) have attracted attention because of their enhanced self-renewal, multipotent capacity, and anti-tumor capacities. However, little is known about Tscm in patients with renal clear cell carcinoma(RCC) and the role of Wnt signaling in these cells. We evaluated Tscm from RCC patients concerning their activation of Wnt signaling in vitro and explored the mechanism of preferential survival.Methods: Flow cytometry identified surface markers and cytokines produced from accumulated Tscm in the presence of the glycogen synthase kinase beta inhibitor TWS119. Apoptosis was evaluated after induction using tumor necrosis factor-alpha.Immunofluorescence and Western blot analyses were used to investigate the activation of the nuclear factor-kappa B(NF-КB)pathway.Results: RCC patients had a similar percentage of CD4^+ and CD8^+ Tscm as healthy donors. Activation of Wnt signaling by TWS119 resulted in the accumulation of Tscm in activated T cells, but reversal of differentiated T cells to Tscm was not achieved.Preferential survival of Tscm was associated with increased anti-apoptotic ability mediated downstream of the NF-КB activation pathway.Conclusions: The finding that Tscm can accumulate by Wnt signaling in vitro in blood from RCC patients will help in devising new cancer therapy strategies of Tscm-based adoptive immunotherapy, such as dendritic cell-stimulated Tscm, and T cell receptor or chimeric antigen receptor-engineered Tscm. | Cihui Yan Jingjing Chang Xinmiao Song Fan Yan Wenwen Yu Yang An Feng Wei Lili Yang Xiubao Ren | 2019 | Cancer Biology & Medicine2019，16，1： | 4 |
| 8 | Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children显示文摘To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported cases.Nine(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1%)were symptomatic and 21(42.9%)were asymptomatic.Neither asymptomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control. | Jiehao Cai Xiangshi Wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali Wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning Wang Jianshe Wang Qirong Zhu Xiaowen Zhai Mei Zeng | 2020 | Virologica Sinica2020，35，6： | 4 |
| 9 | A new tumor-associated antigen prognostic scoring system for spontaneous ruptured hepatocellular carcinoma after partial hepatectomy显示文摘Objective:Spontaneous hepatocellular carcinoma(HCC)rupture can be fatal,and hepatic resection could achieve a favorable long-term survival among all strategies of tumor rupture.However,there is no available prognostic scoring system for patients with ruptured HCC who underwent partial hepatectomy.Methods:From January 2005 to May 2015,129 patients with spontaneous HCC rupture underwent partial hepatectomy.Preoperative clinical data were collected and analyzed.Independent risk factors affecting overall survival(OS)were used to develop the new scoring system.Harrell’s C statistics,Akaike information criterion(AIC),the relative likelihood,and the log likelihood ratio were calculated to measure the homogeneity and discriminatory ability of a prognostic system.Results:In the multivariable Cox regression analysis,three factors,including tumor size,preoperativeα-fetoprotein level,and alkaline phosphatase level,were chosen for the new tumor-associated antigen(TAA)prognostic scoring system.The 1-year OS rates were 88.1%,43.2%,and 30.2%for TAA scores of 0–5 points(low-risk group),6–9 points(moderate-risk group),and 10–13points(high-risk group),respectively.The TAA scoring system had superior homogeneity and discriminatory ability(Harrell’s C statistics,0.693 vs.0.627 and 0.634;AIC,794.79 vs.817.23 and 820.16;relative likelihood,both<0.001;and log likelihood ratio,45.21 vs.22.77 and 21.84)than the Barcelona Clinic Liver Cancer staging system and the Cancer of the Liver Italian Program in predicting OS.Similar results were found while predicting disease-free survival(DFS).Conclusions:The new prognostic scoring system is simple and effective in predicting both OS and DFS of patients with spontaneous ruptured HCC. | Jingjing Wu Peng Zhu Zhanguo Zhang Bixiang Zhang Chang Shu Lin Chen Renjie Feng Abdoul aziz Mba'nbo koumpa Ganxun Li Qianyun Ge | 2018 | Cancer Biology & Medicine2018，15，4： | 4 |
| 10 | Changes in climate regimes over China based on a high-resolution dataset显示文摘During the 20th century the global climate has been shifted towards warmer and drier regimes, mainly due to anthropogenic warming [1,2]. Climate changes can notably disrupt the environment and ecosystems. To evaluate the impacts of climate change on ecoregions, the Kdppen-Trewartha (K-T) climate classification [3] is widely used because it was constructed on the basis of surface vegetation. The K-T classification system combines temperature, precipitation, and their seasonality into a single metric. Six major climate types and several sub-climate types are defined (A: tropical, B: dry, C: subtropical, D: temperate, E: subpolar, F: polar). Each K-T climate type is consistent with certain prevalent plant species. Definitions and criteria of K-T climate types were outlined by Feng et al.[4]. | Wei Huang Jingjing Yan Chang Liu Tingting Xie | 2019 | Science Bulletin2019，64，6： | 3 |
| 11 | Disruption of the bHLH transcription factor Abnormal Tapetum 1 causes male sterility in watermelon显示文摘Although male sterility has been identified as a useful trait for hybrid vigor utilization and hybrid seed production,its underlying molecular mechanisms in Cucurbitaceae species are still largely unclear.Here,a spontaneous male-sterile watermelon mutant,Se18,was reported to have abnormal tapetum development,which resulted in completely aborted pollen grains.Map-based cloning demonstrated that the causal gene Citrullus lanatus Abnormal Tapetum 1(ClATM1)encodes a basic helix-loop-helix(bHLH)transcription factor with a 10-bp deletion and produces a truncated protein without the bHLH interaction and functional(BIF)domain in Se18 plants.qRT–PCR and RNA in situ hybridization showed that ClATM1 is specifically expressed in the tapetum layer and in microsporocytes during stages 6–8a of anther development.The genetic function of ClATM1 in regulating anther development was verified by CRISPR/Cas9-mediated mutagenesis.Moreover,ClATM1 was significantly downregulated in the Se18 mutant,displaying a clear dose effect at the transcriptional level.Subsequent dual-luciferase reporter,β-glucuronidase(GUS)activity,and yeast one-hybrid assays indicated that ClATM1 could activate its own transcriptional expression through promoter binding.Collectively,ClATM1 is the first male sterility gene cloned from watermelon,and its self-regulatory activity provides new insights into the molecular mechanism underlying anther development in plants. | Ruimin Zhang Jingjing Chang Jiayue Li Guangpu Lan Changqing Xuan Hao Li Jianxiang Ma Yong Zhang Jianqiang Yang Shujuan Tian Li Yuan Xian Zhang Chunhua Wei | 2021 | Horticulture Research2021，8，1： | 3 |
| 12 | Knockdown of Oct4 and Nanog expression inhibits the stemness of pancreatic cancer cells显示文摘 | Yuhua Lu Hui Zhu Haiyan Shan Junjie Lu Xu Chang Xiaohong Li Jingjing Lu Xiangjun Fan Shajun Zhu Yao Wang Qingsong Guo Lei Wang Yan Huang Mingyan Zhu Zhiwei Wang | 2013 | Cancer Letters2013，，： | 3 |
| 13 | State-of-the-art and recent developments in micro/nanoscale pressure sensors for smart wearable devices and health monitoring systems显示文摘Small-sized,low-cost,and high-sensitivity sensors are required for pressure-sensing applications because of their critical role in consumer electronics,automotive applications,and industrial environments.Thus,micro/nanoscale pressure sensors based on micro/nanofabrication and micro/nanoelectromechanical system technologies have emerged as a promising class of pressure sensors on account of their remarkable miniaturization and performance.These sensors have recently been developed to feature multifunctionality and applicability to novel scenarios,such as smart wearable devices and health monitoring systems.In this review,we summarize the major sensing principles used in micro/nanoscale pressure sensors and discuss recent progress in the development of four major categories of these sensors,namely,novel material-based,flexible,implantable,and selfpowered pressure sensors. | Ye Chang Jingjing Zuo Hainan Zhang Xuexin Duan | 2020 | Nanotechnology and Precision Engineering2020，3，1： | 3 |
| 14 | Recent Progress of Electrode Materials for Flexible Perovskite Solar Cells显示文摘Flexible perovskite solar cells(FPSCs) have attracted enormous interest in wearable and portable electronics due to their high power-per-weight and low cost. Flexible and efficient perovskite solar cells require the development of flexible electrodes compatible with the optoelectronic properties of perovskite. In this review, the recent progress of flexible electrodes used in FPSCs is comprehensively reviewed. The major features of flexible transparent electrodes, including transparent conductive oxides, conductive polymer, carbon nanomaterials and nanostructured metallic materials are systematically compared. And the corresponding modification strategies and device performance are summarized. Moreover, flexible opaque electrodes including metal films, opaque carbon materials and metal foils are critically assessed. Finally, the development directions and difficulties of flexible electrodes are given. | Yumeng Xu Zhenhua Lin Wei Wei Yue Hao Shengzhong Liu Jianyong Ouyang Jingjing Chang | 2022 | Nano-Micro Letters2022，14，7： | 3 |
| 15 | The role of watermelon caffeic acid O-methyltransferase (ClCOMT1) in melatonin biosynthesis and abiotic stress tolerance显示文摘Melatonin is a pleiotropic signaling molecule that regulates plant growth and responses to various abiotic stresses.The last step of melatonin synthesis in plants can be catalyzed by caffeic acid O-methyltransferase(COMT),a multifunctional enzyme reported to have N-acetylserotonin O-methyltransferase(ASMT)activity;however,the ASMT activity of COMT has not yet been characterized in nonmodel plants such as watermelon(Citrullus lanatus).Here,a total of 16 putative O-methyltransferase(ClOMT)genes were identified in watermelon.Among them,ClOMT03(Cla97C07G144540)was considered a potential COMT gene(renamed ClCOMT1)based on its high identities(60.00–74.93%)to known COMT genes involved in melatonin biosynthesis,expression in almost all tissues,and upregulation under abiotic stresses.The ClCOMT1 protein was localized in the cytoplasm.Overexpression of ClCOMT1 significantly increased melatonin contents,while ClCOMT1 knockout using the CRISPR/Cas-9 system decreased melatonin contents in watermelon calli.These results suggest that ClCOMT1 plays an essential role in melatonin biosynthesis in watermelon.In addition,ClCOMT1 expression in watermelon was upregulated by cold,drought,and salt stress,accompanied by increases in melatonin contents.Overexpression of ClCOMT1 enhanced transgenic Arabidopsis tolerance against such abiotic stresses,indicating that ClCOMT1 is a positive regulator of plant tolerance to abiotic stresses. | Jingjing Chang Yanliang Guo Jingyi Yan Zixing Zhang Li Yuan Chunhua Wei Yong Zhang Jianxiang Ma Jianqiang Yang Xian Zhang Hao Li | 2021 | Horticulture Research2021，8，1： | 2 |
| 16 | Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs显示文摘Although high temperatures influence gut health,data on underlying mechanisms remains scant.Using a pig model,this study performed a global analysis on how chronic heat stress affects the transport and immune function of the gut through transcriptome,proteome,microbial diversity and flow cytometry.A total of 27 pigs with similar body weights were assigned into 3 groups,control(Con)group(23℃),chronic heat stressed(HS)group(33°C),and pair-fed(PF)group,in a controlled environment for 21 days.Our results showed that pigs in the HS group had reduced growth performance and diminished height of ileal villi(P<0.01).Transcriptome and proteome analyses demonstrated notable modification of expression of nutrients and ion transport-related transporters and gut mechanical barrier-related genes by chronic heart stress(P<0.05),suggesting damage of transport functions and the gut barrier.Chronic heat stress-induced endoplasmic reticulum stress also increased the synthesis of misfolded proteins,leading to upregulation of misfolded protein degradation and synthesis,as well as vesicle transport disorder(P<0.05).Energy supply processes were enhanced in the mitochondrion(P<0.05)to maintain biological processes with high energy demands.Furthermore,chronic heat stress activated complement cascade response-related genes and proteins in the gut mucosa(P<0.05).Our flow cytometry assays showed that the proportion of gut lymphocytes(CD4^(+)T cells,T cells,B cells in Peyer’s patch lymphocytes and CD4^(+)CD25^(+)T cells in intraepithelial lymphocytes)were significantly altered in the HS group pigs(P<0.05).In addition,the occurrence of gut microbial dysbiosis in the HS group pigs was characterized by increased potential pathogens(e.g.,Asteroleplasma,Shuttleworthia,Mycoplasma)and suppression of beneficial bacteria(e.g.,Coprococcus and Aeriscardovia),which are associated with gut immune function.Altogether,our data demonstrated that chronic heat stress induced gut transport and immune function disorder associated with endoplasmic reticulum stress in growing pigs. | Shanlong Tang Jingjing Xie Wei Fang Xiaobin Wen Chang Yin Qingshi Meng Ruqing Zhong Liang Chen Hongfu Zhang | 2022 | Animal Nutrition2022，，4： | 2 |
| 17 | Seeing is believing: Developing research skills in international maritime students through authentic learning显示文摘 | Jingjing Xu John Dinwoodie Chia-Hsun Chang | 2012 | International Journal of Management Education2012，，1： | 1 |
| 18 | Changes in DNA base sequences in the mutant of Arabidopsis thaliana induced by low-energy N+ implantation显示文摘 | Fengqi Chang Xuanming Liu Yinxin Li Gengxiang Jia Jingjing Ma Gongshe Liu Zhiqing Zhu | 2003 | Science in China Series C: Life Sciences2003，，5： | 1 |
| 19 | Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases显示文摘在 cyanobacteria 发现的丰满的 alk (a/e ) ne 生合成小径为 biofuel 生产作为一条有希望的其他的途径在最近的年里获得了巨大的注意。Cyanobacterial aldehyde-deformylating oxygenase (cADO ) 催化 C 的变换,潜水艇 class= “ a-plus-plus ” > n 丰满的醛到它的相应 C < 潜水艇 class= “ a-plus-plus ” > n-1 alk (a/e ) ne,是在那条小径的关键酶。由于它的低活动,由 cADO 的 alk (a/e ) ne 生产是一个低效的过程。cADO 的以前的生物化学、结构的调查在它的催化反应上提供了一些信息。然而,它的催化过程的细节仍然保持不清楚。这里,我们从 Synechococcus 报导 cADO 的五水晶结构伸长在两种它的没有铁、包铁的形式的紧张 PCC7942,在它的催化过程期间代表不同状态。结构的比较和功能的酶试金显示那 Glu144,协调铁的残余之一,在 cADO 的催化反应起一个重要作用。而且, Glu144 住的螺旋展出在 cADO 结构与 di 铁中心的不同有约束力的状态相关的二不同符合构造。因此,我们的结果为 cADO di 铁中心的高度易变的特征提供结构的解释,我们建议它与它的低酶的活动有关。根据我们的结构、生物化学的数据, cADO 的一个可能的催化过程被建议,它能与改进活动帮助 cADO 的设计。 | Cheniun Jia Mei Li Jianjun Li Jingjing Zhang Hongmei Zhang Peng Cao Xiaowei Pan Xuefeng LU Wenrui Chang | 2015 | Protein & Cell2015，6，1： | 1 |
| 20 | The Linear 2-Arboricity of Some Planar Graphs 显示文摘 | Xu Changqing Chang Jingjing | 2014 | Ars Combin2014，114，： | 1 |
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