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| 1 | Characteristics of organic phosphorus fractions in different trophic sediments of lakes from the middle and lower reaches of Yangtze River region and Southwestern Plateau, China显示文摘 | Runyu Zhang Fengchang Wu Congqiang Liu Pingqing Fu Wen Li Liying Wang Haiqing Liao Jianyang Guo | 2007 | Environmental Pollution2007，，2： | 5 |
| 2 | Verteporfin synergizes the efflcacy of anti-PD-1 in cholangiocarcinoma显示文摘Background:Cholangiocarcinoma(CCA)is one of the primary hepatobiliary malignant neoplasms with only 10%of 5-year survival rate.Promising immunotherapy with the blockade of immune checkpoints has no clear benefit in CCA.The inhibition of YAP1 signaling by verteporfin has shown encouraging results by inhibiting cell proliferation and inducing apoptosis.This study aimed to evaluate the potential benefit of the combination of verteporfin and anti-programmed cell death 1(PD-1)in CCA mouse model.Methods:We assessed the cytotoxicity of verteporfin in human CCA cell lines in vitro,including both intrahepatic CCA and extrahepatic CCA cells.We examined the in vitro effect of verteporfin on cell proliferation,apoptosis,and stemness.We evaluated the in vivo efflcacy of verteporfin,anti-PD-1,and a combination of both in subcutaneous CCA mouse model.Results:Our study showed that verteporfin reduced tumor cell growth and enhanced apoptosis of human CCA tumor cells in vitro in a dose-dependent fashion.Nevertheless,verteporfin impaired stemness evidenced by reduced spheroid formation and colony formation,decreased numbers of cells with aldehyde dehydrogenase activity and positive cancer stem cell markers(all P<0.05).The combination of verteporfin and anti-PD-1 reduced tumor burden in CCA subcutaneous SB1 tumor model compared to either agent alone.Conclusions:Verteporfin exhibits antitumor effects in both intrahepatic and extrahepatic CCA cell lines and the combination with anti-PD-1 inhibited tumor growth. | Jianyang Fu Nicole A McGrath Jihye Lee Xin Wang Gagandeep Brar Changqing Xie | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 1 |
| 3 | Effects of tannic acid on the immunity and intestinal health of broiler chickens with necrotic enteritis infection显示文摘Background In broiler chickens,necrotic enteritis(NE)infection can reduce production performance.Tannic acid has shown great potential as a treatment of NE in broilers.However,the appropriate dosage of tannic acid in NE of broilers and the improvement effect on intestinal health are not very clear.In this study,we aimed to investigate the effects of different doses of tannic acid on the production performance,immunity,and intestinal health of broilers by constructing an NE model with C.perfringens infection and determining the appropriate dosage of tannic acid with regard to NE.Results Challenged birds showed significant reduction in body weight,villus height,and the ratio of villus height to crypt depth(P<0.05)and increase in the feed consumption gain ratio,intestinal lesion score,and crypt depth(P<0.05).The infection significantly reduced the relative Bacteroidota and Ligilactobacillus abundance(P<0.05)and increased the ratio of Firmicutes/Bacteroidota and cecal content of C.perfringens(P<0.05).Challenged birds fed diets supplemented with tannic acid showed significantly increased mRNA expression of nutrient transport carriers and intestinal barrier genes and growth performance and reduced serum zonulin and endotoxin levels(P<0.05).Addi-tion of tannic acid to the diet inhibited the inflammatory response by reducing the number of coccidia oocysts in feces and the content of C.perfringens in the cecum.Specifically,tannic acid reduced the serum levels of C reactive protein,myeloperoxidase,and specific IgY and ileal mucosal secretory immunoglobulin A levels in the ileal mucosa compared with those in the NE-infected birds.NE-infected birds fed diets supplemented with tannic acid also showed significantly increased relative Anaerocolumna,Thermoanaerobacterium,and Thermosinus abundance(P<0.05);their microbial composition and functional predictions were similar to those of the NC group.Conclusions Tannic acid in the diet alleviated NE by enhancing the intestinal barrier and absorption function.The recommended dietary tannic acid additive level is 500–750 mg/kg.Our study findings would be useful in reducing related economic losses in the broiler industry. | Huiping Xu Jianyang Fu Yimeng Luo Peng Li Bochen Song Zengpeng Lv Yuming Guo | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 1 |
| 4 | Characteristics of organic phosphorus fractions in different trophic sediments of lakes from the middle and lower reaches of Yangtze River region and Southwestern Plateau, China显示文摘 | Runyu Zhang Fengchang Wu Congqiang Liu Pingqing Fu Wen Li Liying Wang Haiqing Liao Jianyang Guo | 2007 | Environmental Pollution2007，，2： | 1 |
| 5 | Temporal and spatial distributions of dissolved organic carbon and nitrogen in two small lakes on the Southwestern China Plateau显示文摘 | Wen Li Fengchang Wu Congqiang Liu Pingqing Fu Jing Wang Yi Mei Liying Wang Jianyang Guo | 2008 | Limnology2008，，2： | 1 |
| 6 | Immunotherapy of hepatocellular carcinoma with infection of hepatitis B or C virus显示文摘Hepatocellular carcinoma(HCC)has one of highest mortalities globally amongst cancers,but has limited therapeutic options once in the advanced stage.Hepatitis B or C virus infection are the most common drivers for HCC carcinogenesis,triggering chronic liver inflammation and adding to the complexity of the immune microecosystem of HCC.The emergence of immunotherapy has afforded a new avenue of therapeutic options for patients with advanced HCC with a history of hepatitis B or C virus infection.This article reviews the change of immunity elicited by hepatitis B or C virus infection,the immune feature of HCC,and the clinical evidence for immunotherapy in advanced HCC and discusses future directions in this field. | Cecilia Monge Bonilla Nicole A.McGrath Jianyang Fu Changqing Xie | 2020 | Hepatoma Research2020，6，10： | 1 |
| 7 | Temporal and spatial distributions of dissolved organic carbon and nitrogen in two small lakes on the Southwestern China Plateau显示文摘 | Wen Li Fengchang Wu Congqiang Liu Pingqing Fu Jing Wang Yi Mei Liying Wang Jianyang Guo | 2008 | Limnology2008，，2： | 1 |
| 8 | 5-3 Code Development for R&D of C-ADS Target Station显示文摘For the R&D of the target station of C-ADS, especially for the conceptual design and feasibility verification of the initiative dense gravity-driven granular flow driven target, a special-purpose program which is accurate and with a sufficiently high efficiency is needed. | Cai Hanjie Fu Fen Li Jianyang Yang Lei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 9 | 5-4 Design Study of Target Parameters for C-ADS显示文摘Both proton beam energy and target parameters play dominant roles on the neutron production multiplicity for a spallation neutron source target. The neutron production multiplicity is undoubtedly the most interesting quantity for spallation target designers. In addition to neutron multiplicity, the beam energy cost per neutron is also an important parameter when designing an ADS facility. | Cai Hanjie Fu Fen Li Jianyang Yang Lei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 10 | Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens显示文摘Background Baicalin and probiotic cocktails are promising feed additives with broad application prospects.While probiotic cocktails are known to enhance intestinal health,the potential synergistic impact of combining baicalin with probiotic cocktails on the gut health of broiler chickens remains largely unexplored.Therefore,this study aims to investigate the influence of the combined administration of baicalin and probiotic cocktails on the composition of ileal and cecal microbiota in broiler chickens to elucidate the underlying mechanisms responsible for the healthpromoting effects.Results A total of 3201-day-old male Arbor Acres broilers were divided into 4 groups,each with 8 replicates of 10 chicks per replicate.Over a period of 42 d,the birds were fed a basal diet or the same diet supplemented with 37.5 g/t baicalin(BC),1,000 g/t probiotic cocktails(PC),or a combination of both BC(37.5 g/t)and PC(1,000 g/t).The results demonstrated that BC+PC exhibited positive synergistic effects,enhancing intestinal morphology,immune function,and barrier function.This was evidenced by increased VH/CD ratio,sIgA levels,and upregulated expression of occludin and claudin-1(P<0.05).16S rRNA analysis indicated that PC potentiated the effects of BC,particularly in the ileum,where BC+PC significantly increased theα-diversity of the ileal microbiota,altered itsβ-diversity,and increased the relative abundance of Flavonifractor(P<0.05),a flavonoid-metabolizing bacterium.Furthermore,Flavonifractor positively correlated with chicken ileum crypt depth(P<0.05).While BC+PC had a limited effect on cecal microbiota structure,the PC group had a very similar microbial composition to BC+PC,suggesting that the effect of PC at the distal end of the gut overshadowed those of BC.Conclusions We demonstrated the synergistic enhancement of gut health regulation in broiler chickens by combining baicalin and probiotic cocktails.Probiotic cocktails enhanced the effects of baicalin and accelerated its metabolism in the ileum,thereby influencing the ileal microbiota structure.This study elucidates the interaction mechanism between probiotic cocktails and plant extract additives within the host microbiota.These findings provide compelling evidence for the future development of feed additive combinations. | Mingkun Gao Chaoyong Liao Jianyang Fu Zhonghua Ning Zengpeng Lv Yuming Guo | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
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