|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The age and tectonic environment of the rhyolitic rocks on the western side of Wuyi Mountain,South China显示文摘During the geological survey of the metamorphic rocks in Xingning-Wuhua region on the western side of Wuyi Mountain, South China, we discovered the Neoproterozoic rhyolite and rhyolitic greywacke for the first time that outcrop in the Proterozoic metamorphic rocks near Jingnan Town of Xingning County, eastern Guangdong Province. A systematic research on petrology, geochemistry and geochronology of rhyolitic rocks was conducted to understand their tectonic setting and formation age. The Jingnan rhyolite is interbedded with a coeval greywacke, with a total thickness of 60 m; both rhyolite and greywacke display a similar folding and metamorphic pattern. Meta-rhyolite consists of groundmass and phenocrystals including sanidine, orthoclase, and quartz with distinct undulose extinction; the groundmass has been recrystallized into fine-grain feldspar, quartz and sericite aggregation. Meta-greywacke is composed of crystallinoclastic grains (sanidine, orthoclase, quartz and oligoclase) and clay groundmass. Zircon grains used for the SHRIMP U-Pb analysis are light brown-colored and euhedral or subeuhedral. Dating data suggest two age groups; eight grains of magmatype zircon with an idiomorphic form yield an age of 972±8 Ma, and the other seven weakly corroded grains of zircon with euhedral to subeuhedral shape construct an average age of 1097±11 Ma, which were captured from older rocks by an uplifting magma, implying that a late Mesoproterozoic basement exists in the Nanling region. In addition, one Paleoproterozoic age, 2035±11 Ma, is obtained from a rounded detrital zircon, indicating that a Paleoproterozoic thermal event took place in the South China. Geochemically, the Jingnan rhyolitic rocks are characterized by high K2O content, intermediate Al2O3 content, with the ACNK value 0.98―1.11, and belonging to high-K alkaline series. They are rich in ΣREE, Rb, Th and Ce, depleted in Ba, Sr, Eu, Ti, P and Nb-Ta, and with moderate negative Eu and Sr anomalies. These features indicate that the Jingnan volcanic rocks have an affinity of continental arc that is similar to those of acid volcanic rocks in the SE-China Coastal Region, in other words, a Neoproterozoic tectonomagma event might have taken place in the western Wuyi region, leading to an eruption of high-K calc-alkaline granitic magma. | SHU LiangShu DENG Ping YU JinHai WANG YanBin JIANG ShaoYong | 2008 | Science China Earth Sciences2008，51，8： | 27 |
| 2 | Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails显示文摘 | Yanbin Fu Chenwen Huang Xinxiu Xu Haifeng Gu Youqiong Ye Cizhong Jiang Zilong Qiu Xin Xie | 2015 | Cell Research2015，25，9： | 24 |
| 3 | Jurassic sedimentary features and tectonic settings of southeastern China显示文摘Two types of the Jurassic basins are distinguished in SE China based on their geodynamic features: the Late Triassic-Early Jurassic post-orogenic basins and the Middle Jurassic intra-continental extensional basins. The Lower Jurassic sequence shows a change from coarseto fine-grained accumulation, suggesting a gradually deepening depositional environment from river to shore-lake and to deep-water lake. In contrast, the Middle Jurassic accumulation was changed from claystone to conglomerate along the coastal provinces in SE China, indicative of an initial crustal uplift. The Wuyi Mountains have been a paleogeograghic separating zone since the Middle Jurassic. The Late Jurassic strata are absent in most areas of SE China. A large-scale bimodal intra-continental rift-type volcanism occurred during the Middle Jurassic along a 40-60 km wide and 200 km long area in western Fujian and southern Jiangxi provinces, which is most likely the strongest volcanism in SE China since the Cambrian. The SHRIMP zircon U-Pb analyses on the rhyolite from the Dongkeng basin in the southern Jiangxi area yield a concord U-Pb age of 160±0.5 Ma, providing an upper age limit for the bimodal volcanic eruption. The analyses of the basin features indicate a change of the depositional environment during the interval from Middle Triassic to Late Triassic from a shallow-sea to an intra-continent in SE China in response to the strong collision between the Yangtze and North China Blocks. Sedimentary structures record a southward direction of Early Jurassic paleo-currents, reflecting that their source areas were to the north side. We propose that the Wuyi region was uplifted as early as Middle Jurassic, followed by a wide E-W-trending extended depression and bimodal volcanism in the western foot of the Wuyi Mountains. Presumably the uplift of the Wuyi domain changed the Middle Jurassic paleo geographic outline and formed the transformational tectonic regime from compression to extension as a tectonic response to the Pacific plate subduction. | SHU LiangShu WANG Yan SHA JinGeng JIANG ShaoYong YU JinHai WANG YanBin | 2009 | Science China Earth Sciences2009，52，12： | 15 |
| 4 | Dietary supplementation with Clostridium butyricum improves growth performance of broilers by regulating intestinal microbiota and mucosal epithelial cells显示文摘Clostridium butyricum has been widely considered an antibiotic substitute in recent years.It can promote growth performance,improve the immune response and enhance the intestinal barrier function of the host.In the present study,1-d-old Arbor Acres(AA)broilers were fed C.butyricum(1×109 cfu/kg)for 28 d.The transcriptomic characteristics of epithelial cells of the cecal mucosa were determined by RNA-sequence,and the cecal microbiota composition was explored by 16 S ribosomal RNA gene sequencing.The changes in the intestinal mucosa of broilers were then analyzed by tissue staining.Gene Ontology(GO)annotations identified substance transport and processes and pathways that might participate in intestinal development and cell viability.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that the differentially expressed genes are involved in numerous pathways related to amino acid and vitamin metabolism and antioxidant and defensive functions,among others.The relative expression of some genes associated with intestinal barrier function(claudins 2,15,19,and 23,tight junction proteins 1,2,and 3 and mucin 1)was significantly increased in the treatment group(P<0.05 or P<0.01).Moreover,the proportion of Firmicutes was higher in the C.butyricum-treated group,whereas the proportion of Proteobacteria was higher in the control group.At the genus level,the relative abundances of Butyricicoccus and Lactobacillus,among other bacteria,were increased after C.butyricum supplementation.The tissue staining analysis showed that the cecal mucosa of broilers was significantly ameliorated after the addition of C.butyricum(P<0.05 or P<0.01).These results showed that dietary supplementation with C.butyricum can enhance the antioxidant capacity,mucosal barrier function,and stabilize the cecal microbiota,resulting in improving the growth performance. | Laipeng Xu Xiangli Sun Xianhua Wan Keke Li Fuchun Jian Wenting Li Ruirui Jiang Ruili Han Hong Li Xiangtao Kang Yanbin Wang | 2021 | Animal Nutrition2021，，4： | 12 |
| 5 | Hierarchical Co3O4 porous nanowires as an efficient bifunctional cathode catalyst for long life Li-O2 batteries显示文摘层次公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 多孔的 nanowires (NW ) 用锻烧跟随的一个热水的方法被综合了。当在非水的Li氧电池作为阴极催化剂采用了时,公司<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 NW 有效地两个都改进双程的效率和骑车的稳定性,它能被归因于公司的高催化的活动<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”>为氧减小反应和氧进化反应的 4 NW 分别地在分泌物和费用期间处理。 | Qingchao Liu Yinshan Jiang Jijing Xu Dan Xu Zhiwen Chang Yanbin Yin Wanqiang Liu Xinbo Zhang | 2015 | Nano Research2015，8，2： | 9 |
| 6 | Possible mechanism underlying analgesic effect of Tuina in rats may involve piezo mechanosensitive channels within dorsal root ganglia axon显示文摘OBJECTIVE: To demonstrate the analgesic effect of Tuina mainly from mechanically sensitive ion channels in peripheral myelinated nerve fibers.METHODS: A total of 40 healthy and pathogen-free adult male Sprague-Dawley rats were used in the study [weight:(220.0 ± 1.4) g, Shanghai Slac Laboratory Animal Co., Ltd., Shanghai, China; license No. Shanghai ICP 05033115]. The rats were housed in cages with free access to water and food in a temperature-controlled room [(22 ± 1) ℃] and12-h/12-h light-dark cycle. Thirty-two rats were randomly divided into five groups: naive, sham, chronic compression of dorsal root ganglion(CCD), Tuina(7 d) and Tuina(21 d). CCD rat model was established via unilateral DRG compression by'L'liked steel bar. Chinese Tuina treatment was accepted once per day. Behavior monitoring of paw withdrawal threshold(PWT) and paw withdrawal latency(PWL) were tested. The expression of Piezo1 and Piezo2 in myelinated nerve fiber were analyzed by immunohistochemistry and Western-blotting.RESULTS: There was a high expression of Piezo2 and a low expression of Piezo1 in the naive and CCD groups. In contrast, the expression of Piezo2 was down regulated and Piezo1 was increased after a period of Tuina. There was significant difference(P ≤ 0.05) between the groups.CONCLUSION: Our findings suggest that Tuina therapy can increase the expression of Piezo2 and decrease the expression of Piezo1 in the test rats.The different changes in the expressions of Piezo1 and Piezo2 may play an important role in alleviating CCD-induced allodynia and hyperalgesia. | Song Pengfei Lin Zhigang Zhu Qingguang Jiang Shichao Zhang Hao Cheng Yanbin Sun Wuquan Wu Zhiwei Zhou Xin Lv Zhizhen Fang Min | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 6 |
| 7 | The spatial pattern of grassland aboveground biomass on Xizang Plateau and its climatic controls显示文摘Aims Grassland is the most widely distributed vegetation type on the Xizang Plateau.Accurate remote sensing estimation of the grass-land aboveground biomass(AGB)in this region is influenced by the types of vegetation indexes(VIs)used,the grain size(resolution)of the remote sensing data and the targeted ecosystem features.This study attempts to answer the following questions:(i)Which VI can most accurately reflect the grassland AGB distribution on the Xizang Plateau?(ii)How does the grain size of remote sensing imagery affect AGB reflection?(iii)What is the spatial distribution pattern of the grassland AGB on the plateau and its relationship with the climate?Methods We investigated 90 sample sites and measured site-specific AGBs using the harvest method for three grassland types(alpine meadow,alpine steppe and desert steppe).For each sample site,four VIs,namely,Normalized Difference VI(NDVI),Enhanced VI,Normalized Difference Water Index(NDWI)and Modified Soil-Adjusted VI(MSAVI)were extracted from the Moderate Resolution Imaging Spectroradiometer(MODIS)products with grain sizes of 250 m and 1 km.Linear regression models were employed to iden-tify the best estimator of the AGB for the entire grassland and the three individual grassland types.Paired Wilcoxon tests were applied to assess the grain size effect on the AGB estimation.General linear models were used to quantify the relationships between the spatial distribution of the grassland AGB and climatic factors.Important Findings The results showed that the best estimator for the entire grass-land AGB on the Xizang Plateau was MSAVI at a 250 m grain size(MSAVI_(250 m)).For each individual grassland type,the best estimator was MSAVI at a grain size of 250 m for alpine meadow,NDWI at a grain size of 1 km for alpine steppe and NDVI at a grain size of 1 km for desert steppe.The explanation ability of each VI for the grassland AGB did not significantly differ for the two grain sizes.Based on the best fit model(AGB=−10.80+139.13 MSAVI_(250 m)),the spatial pattern of the grassland AGB on the plateau was characterized.The AGB varied from 1 to 136 g m^(−2).Approximately 59%of total spatial variation in the AGB for the entire grassland was explained by the combination of the mean annual precipitation(MAP)and mean annual temperature.The explanatory power of MAP was weaker for each individual grassland type than that for the entire grassland.This study illustrated the high efficiency of the VIs derived from MODIS data in the grassland AGB estimation on the Xizang Plateau due to the vegetation homogeneity within a 1×1 km pixel in this region.Furthermore,MAP is a primary driver on the spatial variation of AGB at a regional scale. | Yanbin Jiang Jian Tao Yongqi Huang Juntao Zhu Li Tian Yangjian Zhang | 2015 | Journal of Plant Ecology2015，8，1： | 6 |
| 8 | Microstructure,tensile properties and thermal stability of AlMgSiScZr alloy printed by laser powder bed fusion显示文摘The new generation of Sc and Zr modified Al alloys has been attracted wide concerns in aerospace industry,owing to the excellent mechanical performances and superior thermal stability than other normal Al alloys.By microalloying with Sc and Zr,the Al3(Sc,Zr)particle forms as the grain refiner during the solidification,which is extremely beneficial for the laser powder bed fusion(LPBF)processed Al alloys.In this study,a new type Al-14.1 Mg-0.47 Si-0.31 Sc-0.17 Zr alloy was additively manufactured by LPBF,and the microstructure,tensile properties and thermal stability were studied in detail.By using a single melt-67°scanning strategy,the LPBF-processed specimen with a relative density of 99.4%and tensile strength of 487.7 MPa was obtained at 160 W-200 mm/s.And this AlMgSiScZr alloy can still exhibit an excellent tensile strength of 393.9 MPa at a moderate temperature of 473 K.After the aging treatment,the tensile properties further increased due to the precipitate hardening of Mg2Si and Al3(Sc,Zr),and the maximum value(580 MPa)was reached at an aging time of 10 h.The average crystal size was almost unchanged after aging treated at 325℃and 24 h,indicating this AlMgSiScZr alloy has an improved thermal stability.The AlMgSiScZr alloy is recommended to substitute some particular titanium alloys in aerospace field afterwards. | Jiang Bi Zhenglong Lei Yanbin Chen Xi Chen Ze Tian Nannan Lu Xikun Qin Jingwei Liang | 2021 | Journal of Materials Science & Technology2021，，10： | 4 |
| 9 | Global SH-wave propagation in a 2D whole Moon model using the parallel hybrid PSM/FDM method显示文摘We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids to solve the wave equations and implement the calculation on a parallel PC cluster to improve the computing efficiency. Features of global SH-wave propagation are firstly discussed for a 100-km shallow and900-km deep moonquakes, respectively. Effects of frequency range and lateral variation of crust thickness are then investigated with various models. Our synthetic waveforms are finally compared with observed Apollo data to show the features of wave propagation that were produced by our model and those not reproduced by our models. Our numerical modeling show that the low-velocity upper crust plays significant role in the development of reverberating wave trains. Increasing frequency enhances the strength and duration of the reverberations.Surface multiples dominate wavefields for shallow event.Core–mantle reflections can be clearly identified for deep event at low frequency. The layered whole Moon model and the low-velocity upper crust produce the reverberating wave trains following each phases consistent with observation. However, more realistic Moon model should be considered in order to explain the strong and slow decay scattering between various phases shown on observation data. | Xianghua Jiang Yanbin Wang Yanfang Qin Hiroshi Takenaka | 2015 | Earthquake Science2015，28，3： | 3 |
| 10 | Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide显示文摘Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperature,pressure and paclitaxel content from 313.1 to 343.1K and pressures up to 33.52 MPa.The ternary mixtures exhibit a typical lower critical solution temperature behavior.When paclitaxel content increases,the single-phase region shrinks in size.Three cubic equations of state(Redlich-Kworng,Soave-Redlich-Kwong and Peng-Robinson equation of state) coupled with the van der Waals one-fluid mixing rules were selected to correlate the experimental data.The results indicate that SRK EOS coupled with two binary interaction parameters kij and lij can predict paclitaxel solubility for the best fit of experimental data. | LUO Nin LU Yingmei JIANG Yanbin | 2011 | Chinese Journal of Chemical Engineering2011，19，4： | 3 |
| 11 | Current-driving intergranular corrosion performance regeneration below the precipitates solvus temperature in Al–Mg alloy显示文摘Heat treatment is an effective method to improve the intergranular corrosion resistance of the sensitized Al–Mg alloy due to dissolution of the grain boundary precipitates above the solvus temperature ofβ-phase.The grain boundary precipitates will grow and coarsening below the solvus temperature.In this study,the in-situ intergranular corrosion performance regeneration of the sensitized Al–Mg alloy can be realized by low-density electro-pulsing treatment below the solvus temperature ofβ-phase.Our findings show that the dissolution of grain boundary precipitates by electro-pulsing treatment is accelerated at relatively low temperature in comparison to traditional heat treatment.The athermal effect produced by the interaction between atoms and electrons on the dissolution of grain boundary precipitates is the main reason for the improved corrosion resistance below the solvus temperature ofβ-phase. | Di Zhang Zhen Zhang Yanlin Pan Yanbin Jiang Linzhong Zhuang Jishan Zhang Xinfang Zhang | 2020 | Journal of Materials Science & Technology2020，52，18： | 3 |
| 12 | A microfluidic biosensor for rapid detection of Salmonella typhimurium based on magnetic separation,enzymatic catalysis and electrochemical impedance analysis显示文摘Rapid screening of foodborne pathogens is of great significance to ensure food safety.A microfluidic biosensor based on immunomagnetic separation,enzyme catalysis and electrochemical impedance analysis was developed for rapid and sensitive detection of S.typhimurium.First,the bacterial sample,the magnetic nanoparticles(MNPs)modified with capture antibodies,and the enzymatic probes modified with detection antibodies and glucose oxidase(GOx)were simultaneously injected into the microfluidic chip,followed by mixing and incubation to form MNP-bacteria-probe sandwich complexes.Then,glucose with high impedance was injected into the chip and catalyzed by the GOx on the complexes into hydrogen peroxide with high impedance and gluconic acid with low impedance,which was finally measured using the low-cost interdigitated microelectrode and the electrochemical impedance analyzer to determine the target bacteria.Under the optimal conditions,this biosensor could quantitatively detect S.typhimurium at the concentrations from 1.6×10^(2) CFU/m L to 1.6×10^(6) CFU/m L in 1 h with the low detection limit of 73 CFU/m L.Besides,this biosensor was demonstrated with good feasibility for practical applications by detecting the S.typhimurium spiked chicken meat samples. | Yingjia Liu Dong Jiang Siyuan Wang Gaozhe Cai Li Xue Yanbin Li Ming Liao Jianhan Lin | 2022 | Chinese Chemical Letters2022，33，6： | 3 |
| 13 | Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients显示文摘N-cadherin is related to the progression and metastases of several solid carcinomas.However,it was still unclear whether N-cadherin is overexpressed in colorectal malignant tumors that have stronger malignant tendency.In this study,we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120patients with colorectal cancer.We revealed that N-cadherin was expressed in 78.3%(94/120)of colorectal tumor tissues and in only 9.2%(11/120)of paired distant normal mucosa tissues with a significant difference(P=0.000).The low,moderate,and high expression of N-cadherin protein was 42.5%,30.8%,and 26.7%,respectively.N-cadherin overexpression was associated with advanced TNM stage,lymph nodes metastasis and distant metastasis(P<0.05).Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression,and patients with low expression had a better survival rate than those with moderate and high expression(P<0.05).In conclusion,high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer,and may prove to be a possible prognostic factor. | ZHUO HongQing JIANG KeWei DONG LingYi ZHU Yi Lü Liang Lü You ZHANG YanBin ZHANG Hui YE YingJiang WANG Shan | 2013 | Chinese Science Bulletin2013，58，28： | 2 |
| 14 | Impacts of water resource planning on regional water consumption pattern: A case study in Dunhuang Oasis, China显示文摘Water resources are critical for the existence and development of oases in endorheic basins.Thus,to enable sustainable development,it is fundamentally important to understand how to allocate and use these resources in a reasonable way.We therefore simulated and analyzed changes in water consumption pattern within the Dunhuang Oasis of China under three scenarios using a system dynamic model that corresponds to different water consumption pattern.This was done to assess the impacts of regional water resource planning(comprehensive planning of the rational use of water resource and protection of ecosystem services in the Dunhuang Basin)on water consumption pattern within the Dunhuang Oasis.The first of these,Scenario 1,is a baseline in which the status quo is maintained,while Scenario 2 incorporates the comprehensive effects of agricultural water-saving irrigation measures with an inter-basin water diversion project,and Scenario 3 focuses on ecological rehabilitation.In the baseline Scenario 1,the total water consumption within the Dunhuang Oasis increased progressively while agricultural water consumption remained extremely high and threatened overall ecological security.In contrast,Scenario 2 would decrease agricultural water consumption by almost 5.30×10^7 m^3 following the implementation of water-saving practices.The additional water allocated from an inter-basin water diversion project would play an important role in alleviating ecological strain on the oasis.Finally,in Scenario 3,the total irrigated land must be decreased to 20.6×10^3 hm^2 by 2025 assuming that water supply for ecosystem restoration would be at least 50%of the total consumption.Although water resource planning plays a very important role in alleviating the ecological water crisis within the oasis,it is necessary to consider the suitable scale of oasis with regard to current water consumption pattern. | ZHANG Xifeng JIN Xin BAI Xiao JIANG Yanbin HE Chansheng | 2019 | Journal of Arid Land2019，11，5： | 2 |
| 15 | Interacting plexcitons for designed ultrafast optical nonlinearity in a monolayer semiconductor显示文摘Searching for ideal materials with strong effective optical nonlinear responses is a long-term task enabling remarkable breakthroughs in contemporary quantum and nonlinear optics.Polaritons,hybridized light-matter quasiparticles,are an appealing candidate to realize such nonlinearities.Here,we explore a class of peculiar polaritons,named plasmon–exciton polaritons(plexcitons),in a hybrid system composed of silver nanodisk arrays and monolayer tungsten-disulfide(WS2),which shows giant room-temperature nonlinearity due to their deep-subwavelength localized nature.Specifically,comprehensive ultrafast pump–probe measurements reveal that plexciton nonlinearity is dominated by the saturation and higher-order excitation-induced dephasing interactions,rather than the well-known exchange interaction in traditional microcavity polaritons.Furthermore,we demonstrate this giant nonlinearity can be exploited to manipulate the ultrafast nonlinear absorption properties of the solid-state system.Our findings suggest that plexcitons are intrinsically strongly interacting,thereby pioneering new horizons for practical implementations such as energy-efficient ultrafast all-optical switching and information processing. | Yuxiang Tang Yanbin Zhang Qirui Liu Ke Wei Xiang’ai Cheng Lei Shi Tian Jiang | 2022 | Light(Science & Applications)2022，11，5： | 2 |
| 16 | An additively manufactured Al-14.1Mg-0.47Si-0.31Sc-0.17Zr alloy with high specific strength,good thermal stability and excellent corrosion resistance显示文摘A novel Al-14.1 Mg-0.47 Si-0.31 Sc-0.17 Zr alloy was applied in the printing process of selective laser melting(SLM),and the corresponding microstructural feature,phase identification,tensile properties and corrosion behavior of the Al Mg Si Sc Zr alloy were studied in detail.As fabricated at 160 W and 200 mm/s,the Mg content of bulk sample decreased to 11.7 wt%due to the element vaporization at high energy density,and the density of this additively manufactured Al Mg Si Sc Zr alloy was 2.538 g/cm^(3),which is4.2%8.5%lighter than that of other SLM-processed Al alloys.After heat-treated(HT)at 325℃and 6 h,the microstructure was almost unchanged with an alternate distribution of fine equiaxed crystals and coarse columnar crystals.Nano-sized Al3(Sc,Zr)and Mg_(2)Si phases precipitated dispersedly in the Al matrix,and the tensile strength increased from 487.6 MPa to 578.4 MPa for precipitation strengthening and fine grain strengthening.With a fine grain size of 2.53μm,an excellent corrosion resistance was obtained for the as-printed(AP)Al Mg Si Sc Zr alloy.While the corrosion resistance of HT sample decreased slightly for the formation of non-dense oxide layer and pitting corrosion induced by diffuse precipitation distribution.This SLM-printed Al Mg Si Sc Zr alloy with high specific strength,good thermal stability and excellent corrosion resistance has broad prospects for the aerospace and automotive applications. | Jiang Bi Zhenglong Lei Yanbin Chen Xi Chen Nannan Lu Ze Tian Xikun Qin | 2021 | Journal of Materials Science & Technology2021，，8： | 2 |
| 17 | Enhancing the stability of astaxanthin by encapsulation in poly (1-lactic acid) microspheres using a supercritical anti-solvent process显示文摘To improve the physicochemical properties of astaxanthin, it was encapsulated in poly (1-lactic acid)(PLLA) using a supercritical anti-solvent (SAS) process with dichloromethane/acetone mixture as the solvent, and supercritical CO2 as the anti-solvent. The effects of altering five SAS operating cond让ions, solvent ratio, temperature, pressure, concentration of carrier, and flow rate, on the microstructure of particles were investigated using an orthogonal experimental design. Under the optimal conditions, astaxanthin/PLLA particles were produced with an encapsulation efficiency of 91.5% and a mean particle size of 954.6 nm. SEM images showed that most astaxanthin/PLLA particles were uniform microspheres. FT-IR spectra showed that the chemical structure of astaxanthin was unchanged by the SAS process. The results of chromatic difference, X-ray diffraction, thermogravimetric, and differential scanning calorimetry analyses showed that astaxanthin had been encapsulated in the PLLA matrix in an amorphous state. Overall, astaxanthin/PLLA microspheres greatly enhanced the stability of astaxanthin during storage, and the levels of residual solvents were far lower than the ICH lim让s. This means that astaxanthin/PLLA microspheres prepared using SAS show great potential for use in many food, cosmetic, and pharmaceutical formulations. | Guijin Liu Man Hu Ziyi Zhao Qing Lin Dongwei Wei Yanbin Jiang | 2019 | Particuology2019，17，3： | 2 |
| 18 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 19 | BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis显示文摘We previously showed that B cell receptor associated protein 31(BAP31) was significantly upregulated in colorectal cancer compared with normal mucosa epithelia. However, its expression pattern and pathological role in colorectal cancer are not clearly understood. In this study, we investigated whether the expression of BAP31 was associated with the clinicopathological parameters of colorectal cancer. The expression pattern of BAP31 was detected by immunohistochemistry on a tissue microarray in both primary tumor and paired distant normal mucosa samples from 120 consecutive colorectal cancer patients. Furthermore, BAP31 protein expression was also determined in twenty colorectal adenomas and eight liver metastasis samples. There was positive expression of BAP31 in 64.17% of primary tumors and 6.67% in distant normal mucosa (P=0.000). Negative expression of BAP31 was correlated with distant metastasis (P=0.036) and lower tumor differentiation grade (P=0.001). Patients with BAP31-negative expression showed significantly lower overall survival rate (P=0.003) compared to patients with BAP31-positive expression. Our results demonstrate that BAP31 may serve as a candidate prognostic marker in colorectal cancer and negative BAP31 expression may lead to more aggressive invasion of colorectal cancer. | DONG LingYi JIANG KeWei ZHANG YanBin ZHANG Hui ZHUO HongQing CUI ZhiRong YE YingJiang WANG Shan | 2011 | Chinese Science Bulletin2011，56，23： | 2 |
| 20 | Effects of annealing and cold roll-bonded interface on the microstructure and mechanical properties of the embedded aluminum-steel composite sheet显示文摘Embedded aluminum-steel composite sheets used in heat exchanger were produced by cold roll bonding(CRB). The influences of annealing temperature and annealing time on the microstructure and the bonding strength of the composite sheet were investigated. The recrystallization of the steel layer began at 525℃ and finished at 600℃. With the increase of the annealing temperature, the peel strength of the composite sheet whose original steel sheet surface was treated by scratch brush initially increased and then decreased, which was resulted from the competition of the mechanical locking and metallurgical bonding. After annealing, the cracks which formed between the broken work-hardened steel surface layer and its matrix during cold roll bonding remained. The composite sheet produced by CRB with the steel surface treatment of flap disc had less interfacial defects, higher bonding quality, higher diffusion rate of Al and Fe atoms at the interface and larger metallurgical bonding extent than the composite sheet produced by CRB with the steel surface treatment of scratch brush under the same conditions of annealing,which was helpful to shorten annealing time, reduce energy consumption and improve production efficiency. | Chunyang Wang Xinhua Liu Yanbin Jiang Jianxin Xie Xiaojun Zhang Dejing Zhou | 2018 | Science Bulletin2018，63，21： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员