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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Posterior interosseous free flap: Various types显示文摘 | Park JJ Kim JS Chung JI | 1997 | Plast Reconstr Surg1997，100，5： | 1 |
| 3 | Hypermethylation of RASSF1a promoter is associated with the age at the starting smoking and a poor prognosis in primary non-small cell cancer显示文摘 | Kim DH Kim JS Ji YI | 2003 | Cancer Res2003，63，13： | 1 |
| 4 | Valproate,hyperandrogenism, and polycystic ovaries:a report of 3 cases显示文摘 | Tapanainen JS | 2000 | Arch Neurol2000，57，7： | 1 |
| 5 | Complications of pneumoconiosis:radiologic overview显示文摘 | Jun JS Jung JI Kim HR | 2013 | Eur J Radiol2013，82，10： | 1 |
| 6 | The complete sequence of the mucosal pathogen Ureaplasma urealyticum 显示文摘 | Glass JI Lefkowitz EJ Glass JS | 2000 | Nature2000，407，6805： | 1 |
| 7 | Valproate,hyperandrogenism,and polycystic ovaries,A report of 3 case显示文摘 | Isojarvi JI Tapanainen JS | 2000 | Arch Neurol2000，279，3： | 1 |
| 8 | Functional insight from the tetratri- copeptide repeat-like motifs of the type III secretion chaperone SicA in Salmonella enterica serovar Typhimurium 显示文摘 | Kim JS Kim BH Jang JI | 2014 | FEMS Microbiol Lett2014，350，2： | 1 |
| 9 | High factor Ⅷ or homocysteine levels and thrombosis in Henoch- Schonlein purpura显示文摘 | Shin JI Lee JS | 2008 | Rheumatol Int2008，28，9： | 1 |
| 10 | Recurrence - free long term survival after liver transplantation for hepatitis B using interferon - alpha pretransplant and hepatitis B immune globulin posttransplant 显示文摘 | Techervenkov JI Tector AJ Barkun JS | 1997 | Ann Surg1997，226，： | 1 |
| 11 | Posterior scleral reinforcement in the treatment of macular retinoschisis in highly myopic patients显示文摘 | Zhu ZC Ji XY Zhang JS | | 0，，07： | 1 |
| 12 | Stereotactic aspiration of in tracerebral haematoma: significance of surgical timing and haematoma volume reduction 显示文摘 | Lee JI Nam DH Kim JS | 2003 | J Clin Neurosci2003，10，4： | 1 |
| 13 | The diagnostic value of IgA deposition inHe-noch-Sch nlein purpura显示文摘 | Shin JI Kim JH Lee JS | 2008 | Pediatr Dermatol2008，25，1： | 1 |
| 14 | Abnormalities in the con- tractile properties of colonic smooth muscle in idiopathic slow tran- sit constipation 显示文摘 | Slater BJ Varma JS Gillespia JI | 1997 | Br J Surg1997，84，2： | 1 |
| 15 | Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer显示文摘 | Kim DH Kim JS Ji YI | 2003 | Cancer Res2003，63，13： | 1 |
| 16 | Endoscopic and histopathologic pre- dictors of recurrence of colorectal adenoma on lowering the miss rate 显示文摘 | Ji JS Choi KY Lee WC | 2009 | Korean J Intern Med2009，24，： | 1 |
| 17 | Tow-dimensional gel database of human breast carcinoma cell expressed proteins:an update显示文摘 | Ji H Eddes JS | 1998 | Electrophoresis1998，19，5： | 1 |
| 18 | Glioma stem cell research for the development of immunotherapy显示文摘 | Ji J Black KL Yu JS | | 0，，01： | 1 |
| 19 | Chondrocyte allograft transplantation for damaged growth plate reconstruction 显示文摘 | Park JS Ahn JI Oh DI | 1994 | Yonsei Med J1994，35，： | 1 |
| 20 | Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary ono-small cell lung cancer显示文摘 | Kim DH Kim JS Ji YI | 2003 | Cancer Res2003，63，： | 1 |
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