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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 3 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 4 | Direct imaging of the spatial and energy distribution of nucleation centres in ferroelectric materials 显示文摘 | Jesse S Rodriguez B J Choudhury S | 2008 | Nature Materials2008，7，3： | 1 |
| 5 | Epimerisation of menthol stereoisomers: Kinetic studies of the heterogeneously catalysed menthol production显示文摘 | Etzold B Jess A Nobis M | 2009 | Catalysis Today2009，140，12： | 1 |
| 6 | Biology,rearing and field release on Guam of Euplectrus a parasituid of the fruit-piercing moth,Eudocoma fullonia显示文摘 | Muniappan R Jesse B Reddy G U P | 2004 | Biocontrol2004，49，： | 1 |
| 7 | A lightweight compact 2D/3D autostereoscopic LCD backlight for games,monitor,and notebook application显示文摘 | Eichenlaub Jesse B | 1998 | Proceedings of SPIE1998，3295，： | 1 |
| 8 | Sheep rumen metabolic development in response to age and dietary treatments显示文摘 | Lane M A Baldwin R L Jesse B W | 2000 | J Anim Sci2000，78，： | 1 |
| 9 | Genome-wide nested asso- ciation mapping of quantitative resistance to northern leaf blight in maize显示文摘 | Jesse A P Peter J B Edward S B | 2011 | PNAS2011，108，17： | 1 |
| 10 | Management of radial head fractures:current concepts显示文摘 | Laurens Kaas Jesse B Jupiter C | | 0，，01： | 1 |
| 11 | Management of radial head fractures: current concepts 显示文摘 | Laurens Kaas Jesse B Jupiter C | 2011 | Shoulder & Elbow2011，3，： | 1 |
| 12 | Effect of volatile fatty acid infusion on development of neonatal sheep rumen epithelium显示文摘 | Lane M A Jesse B W | 1997 | J Dairy Sci1997，80，： | 1 |
| 13 | Eichenlaub,Progress in autostereoscopic cisplay technology at dimension technologies Inc显示文摘 | Jesse B | 1991 | Proceedings of SPIE1991，1457，： | 1 |
| 14 | A case of mesenteric inflammatory veno-occlusive disease mimicking new onset inflammatory bowel disease in a healthy 71-year-old man显示文摘 | Therese B Jesse G Emma F | 2014 | Inflammatory Bowel Diseases2014，20，1： | 1 |
| 15 | Skeletal trauma显示文摘 | Bruce D Browner Jesse B | 2001 | 1839 -18412001，，： | 1 |
| 16 | Interconversion between γ-valerolactone and pentenoic acid combined with decarboxylation to form butene over silica/alumina显示文摘 | Jesse Q B Wang D Alonso M D | | 0，，02： | 1 |
| 17 | Technical note:Isolation and characteriyatin of sheep ruminal epithelial cell显示文摘 | Baldwin R L Jesse B W | 1991 | J Anim Sci1991，69，： | 1 |
| 18 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 19 | Preferentia l chemotaxis of activated human CD4 + T cells by extracellular cyclophilin A显示文摘 | Jesse M Michael I B Stephanie LC | 2007 | J Leukoc Biol2007，82，9： | 1 |
| 20 | Deep desulfurization of oil refinery streams by extraction with ionic liquids 显示文摘 | Jochen A B Peter W Jess A | 2004 | Green Chem2004，6，： | 1 |
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