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| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 3 | Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?显示文摘BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to occur.Conventional coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left untreated.Thromboelastogram(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide anticoagulation.TEG is better than CCT because it is dynamic and provides a global hemostatic profile including fibrinolysis.AIM To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant recipients.METHODS A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG results.Graft loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were compared.RESULTS Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on CCT.No graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45.10%in the CCT group(P=0.05,Fisher’s exact test).The incidence of radiologically confirmed partial thrombus in pancreas allograft was 41.18%in the TEG and 25.50%in the CCT group(P=0.23,Fisher’s exact test).All recipients with partial thrombi detected in computed tomography(CT)scan had an anticoagulation dose escalation.The thrombus resolution rates in subsequent scan were 85.71%and 63.64%in the TEG group vs the CCT group(P=0.59,Fisher’s exact test).The TEG group had reduced blood product usage{10 packed red blood cell(PRBC)and 2 fresh frozen plasma(FFP)}compared to the CCT group(71 PRBC/10 FFP/2 cryoprecipitate and 2 platelets).The proportion of patients requiring transfusion in the TEG group was 17.65%vs 39.25%in the CCT group(P=0.14,Fisher’s exact test).The median length of hospital stay was 18 days in the TEG group vs 31 days in the CCT group(P=0.03,Mann Whitney test).The 1-year pancreas graft survival was 100%in the TEG group vs 82.35%in the CCT group(P=0.07,log rank test)and,the 1-year kidney graft survival was 100%in the TEG group vs 92.15%in the CCT group(P=0.23,log tank test).CONCLUSION TEG is a promising tool in guiding judicious use of anticoagulation with concomitant prevention of graft loss due to thrombosis,and reduces the length of hospital stay. | Jeevan Prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois Anand SR Muthusamy | 2020 | World Journal of Transplantation2020，10，7： | 2 |
| 4 | Magnetic manipulation of copper-tin nanowires capped with nickel ends显示文摘 | ANNE K B JEREMY S T ARTHUR B E WENDY C C | 2004 | Nano Letters2004，4，3： | 1 |
| 5 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 6 | Nitrite-induced deamination and hypo- chlorite-induced oxidation of DNA in intact human respiratory tract epithelial ceils 显示文摘 | Jeremy P Spencer E Whtteman M | 2000 | J Free Radical Biology & Medicine2000，28，7： | 1 |
| 7 | Viscoelastic properties of polystyrene and poly ( methyl methacrylate ) dispersions sterically stabilized by hydrophobically modified inulin ( polyfructose ) polymeric surfactant显示文摘 | Jeremie N Marc O Jordi E | 2008 | Journal of Colloid and Interface Science2008，，1： | 1 |
| 8 | Hemispheric Cognitive Style:A Comparison of Three Instruments显示文摘 | | 2005 | The Journal of Genetic Psychology2005，166，4： | 1 |
| 9 | The interactions of flavonoids withinneuronal signalling pathways 显示文摘 | Jeremy P E Spencer | 2008 | Genes & Nutrition2008，2，3： | 1 |
| 10 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 11 | A novel approach to improving the mechanical properties in recycled vulcanized natural rubber and its mechanism显示文摘 | Amiya R Tripathy Jeremy E Morin Drew E Williams | 2002 | Macromolecules2002，35，12： | 1 |
| 12 | Seasonal and Inter-Annual Relationships Between Vegetation and Climate in Central New Mexico, USA显示文摘 | JEREMY L W DAVIDS S G JULIA E A | 2004 | Journal of Arid Environments2004，57，4： | 1 |
| 13 | Fibroblast growth fhctor receptor signaling is dictated by specific heparan sulphate saccharides显示文摘 | Scott E Guimond Jeremy E Turnbull | 1999 | Current Biology1999，9，： | 1 |
| 14 | A critical analysis of the reported association between vasectomy and frontotemporal dementia显示文摘 | Tobias S K6hler Jeremy T Choy Anees A Fazili Joel F Koenig Robert E Brannigan | 2012 | Asian Journal of Andrology2012，14，6： | 1 |
| 15 | Synthesis of nanoscale NbSe2 materials from molecular precursors 显示文摘 | Perumal S Eric C G Jeremy E | 2005 | J Am Chem Sog2005，127，： | 1 |
| 16 | Sustainable Development and Environment : a Renewed Effort in the OECD Environment 显示文摘 | Jeremy E | 1999 | Development and Sustainability1999，1，： | 1 |
| 17 | Avifauna of the Gaoligong Shan Mountains of western China: a hotspot of avian species diversity显示文摘 | John P D Jeremy M Maureen E | 2010 | Or- nithological Monographs2010，70，： | 1 |
| 18 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 19 | Flavonoids:antioxidants or signaling molecule显示文摘 | ROBERT J W JEREMY P E CATHERINE R E | 2004 | Free Radical Biology andMedicine2004，36，7： | 1 |
| 20 | Ownership concentration and share valuation 显示文摘 | Jeremy E Weichenrieder A J | 2004 | German Economic Review2004，5，2： | 1 |
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