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| 1 | Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma显示文摘AIM To explore factors associated with persistent hepatitis B virus(HBV) infection in a cohort of hepatocellular carcinoma(HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen(HBsA g)-positive relatives. METHODS We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structuredquestionnaire. Demographics, relationship to index case, HBs Ag status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation(P = 0.0076), index generation(P = 0.0044), mothers positive for HBs Ag(P = 0.0007), and HBs Ag-positive index cases(P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBs Ag-positive relatives. Parent generation(P = 0.0359) and sex(P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBs Ag-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46(58.7%) families. Male offspring of HBsA gpositive mothers(P = 0.024) and older siblings were associated with high viral load.CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations. | Ai-Ru Hsieh Cathy SJ Fann Chau-Ting Yeh Hung-Chun Lin Shy-Yi Wan Yi-Cheng Chen Chia-Lin Hsu Jennifer Tai Shi-Ming Lin Dar-In Tai | 2017 | World Journal of Gastroenterology2017，23，5： | 2 |
| 2 | Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families显示文摘BACKGROUND Genome-wide association studies from Asia indicate that HLA-DP and HLA-DQ loci are important in persistent hepatitis B virus(HBV)infections.One of the key elements for HBV-related carcinogenesis is persistent viral replication and inflammation.AIM To examine genetic and nongenetic factors with persistent HBV infection and viral load in families with hepatocellular carcinoma(HCC).METHODS The HCC families included 301 hepatitis B surface antigen(HBsAg)carriers and 424 noncarriers born before the nationwide vaccination program was initiated in 1984.Five HBV-related single nucleotide polymorphisms(SNPs)—rs477515,rs9272105,rs9276370,rs7756516,and rs9277535—were genotyped.Factors associated with persistent HBV infection and viral load were analyzed by a generalized estimating equation.RESULTS In the first-stage persistent HBV study,all SNPs except rs9272105 were associated with persistent infection.A significantly higher area under the reciprocal operating characteristic curve for nongenetic factors vs genetic factors(P<0.001)suggests that the former play a major role in persistent HBV infection.In the second-stage viral load study,we added 8 HBsAg carriers born after 1984.The 309 HBsAg carriers were divided into low(n=162)and high viral load(n=147)groups with an HBV DNA cutoff of 105 cps/mL.Sex,relationship to the index case,rs477515,rs9272105,and rs7756516 were associated with viral load.Based on the receiver operating characteristic curve analysis,genetic and nongenetic factors affected viral load equally in the HCC family cohort(P=0.3117).CONCLUSION In these east Asian adults,the mechanism of persistent HBV infection-related SNPs was a prolonged viral replication phase. | Ai-Ru Hsieh Cathy S J Fann Hung-Chun Lin Jennifer Tai Sen-Yung Hsieh Dar-In Tai | 2021 | World Journal of Gastroenterology2021，27，37： | 1 |
| 3 | Acoustic radiation force impulse predicts long-term outcomes in a large-scale cohort:High liver cancer,low comorbidity in hepatitis B virus显示文摘BACKGROUND Acoustic radiation force impulse(ARFI)is used to measure liver fibrosis and predict outcomes.The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus(HBV)than in other etiologies of chronic liver disease.AIM To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease.METHODS Consecutive patients who received an ARFI study between 2011 and 2018 were enrolled.After excluding dual infection,alcoholism,autoimmune hepatitis,and others with incomplete data,this retrospective cohort were divided into hepatitis B(HBV,n=1064),hepatitis C(HCV,n=507),and non-HBV,non-HCV(NBNC,n=391)groups.The indexed cases were linked to cancer registration(1987-2020)and national mortality databases.The differences in morbidity and mortality among the groups were analyzed.RESULTS At the enrollment,the HBV group showed more males(77.5%),a higher prevalence of prediagnosed hepatocellular carcinoma(HCC),and a lower prevalence of comorbidities than the other groups(P<0.001).The HCV group was older and had a lower platelet count and higher ARFI score than the other groups(P<0.001).The NBNC group showed a higher body mass index and platelet count,a higher prevalence of pre-diagnosed non-HCC cancers(P<0.001),especially breast cancer,and a lower prevalence of cirrhosis.Male gender,ARFI score,and HBV were independent predictors of HCC.The 5-year risk of HCC was 5.9%and 9.8%for those ARFI-graded with severe fibrosis and cirrhosis.ARFI alone had an area under the receiver operating characteristic curve(AUROC)of 0.742 for prediction of HCC in 5 years.AUROC increased to 0.828 after adding etiology,gender,age,and platelet score.No difference was found in mortality rate among the groups.CONCLUSION The HBV group showed a higher prevalence of HCC but lower comorbidity that made mortality similar among the groups.Those patients with ARFI-graded severe fibrosis or cirrhosis should receive regular surveillance. | Jennifer Tai Adam P Harrison Hui-Ming Chen Chiu-Yi Hsu Tse-Hwa Hsu Cheng-Jen Chen Wen-Juei Jeng Ming-Ling Chang Le Lu Dar-In Tai | 2023 | World Journal of Gastroenterology2023，29，14： | 1 |
| 4 | Virus vector for gene silencing in wheat 显示文摘 | Tai Y S Jennifer Bragg Michael C | 2005 | Bio Techiniques2005，39，： | 1 |
| 5 | The role of genetic factors in HBV-related HCC:perspectives from local genetic backgrounds and clinical epidemiology显示文摘Familial clustering of hepatitis B surface antigen carriers(HBsAg)and hepatocellular carcinoma(HCC)has led to the evaluation of the role of genetics in hepatitis B-related diseases.Consistent reports indicate that the HLA-DP and-DQ loci are associated with persistent hepatitis B virus(HBV)infection.However,for hepatocarcinogenesis,existing studies have low power and conflicting data.Global single nucleotide polymorphism(SNP)data was collected from the 1000 Genomes Project and correlated with local epidemiological information.Southeastern Asia has a higher prevalence of HBsAg than Northeastern Asia;this was used in the evaluation of persistent HBV infection.The higher incidence of HCC in West Africa compared with East Africa was used in the evaluation of hepatocarcinogenesis.The allele frequencies for SNPs were significantly different between East Asians and Africans.Therefore,SNPs that have been identified in persistent HBV infections in East Asia may not be completely applicable in Africa.SNPs in NTCP,CTF19,and the HLA-DQ and-DP loci showed North-to-South allele frequency changes in East Asia.These findings confirm the role of genetics in persistent HBV infection.Some of the SNPs in the HLA loci show a trend of West-to-East allele frequency changes in Africa,indicating they may participate in hepatocarcinogenesis.Among the non-HLA related SNPs,rs2596542 in MICA shows a strong trend of allele frequency changes and is correlated with HCC incidence in Africa.SNPs in KIF1,IL-1A,and STAT4 also show,albeit with low statistical power,allele frequency trends compatible with HCC incidence.Taken together,there are strong correlations between background genetics in HLA-DP and-DQ loci with persistent HBV infection and hepatocarcinogenesis.The correlations were weak-positive in non-HLA loci. | Dar-In Tai Jennifer Tai | 2020 | Hepatoma Research2020，6，11： | 0 |
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