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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Differential expression of the MAD2 ,BUB1 and HSP27 genes in Barrett's oesophagus-their association with aneuploidy and neoplastic progression 显示文摘 | Doak SH Jenkins GJS Parry EM | 2004 | Mutat Res2004，547，12： | 1 |
| 3 | Science显示文摘 | Murphy C J Arkin M R Jenkins Y Ghatlia N D Bossmann SH Turro N J Barton J K | 1993 | 262:10251993，262，： | 1 |
| 4 | Differences in food hoarding among six species of heteromyid rodents显示文摘 | Jenkins SH Breck SW | | 0，，04： | 1 |
| 5 | Deoxycholic acid at neutral and acid pH,is genotoxic to oesophageal cells through the induction of ROS: The potential role of antioxidants in Barretts oesophagus显示文摘 | JenKins GJ D Souza FR Suzen SH | 2007 | Carcinogenesis2007，28，1： | 1 |
| 6 | Characterisation of p53 status at the gene,chromosomal and protein levels in oesophageal adenocarcinoma显示文摘 | Doak SH Jenkins GJ Parry EM | 2003 | Br J Cancer2003，89，： | 1 |
| 7 | Differential expression of the MAD2,BUB1 and HSP27 genes in Barret's oesophagus-their association with an euploidy and neoplastic progression显示文摘 | Doak SH Jenkins GJ Parry EM | 2004 | Mutat Res2004，547，12： | 1 |
| 8 | Effect of subgingival scaling during supportive therapy 显示文摘 | Jenkins WMM Said SH Radvar M | 2000 | J Clin Periodontol2000，27，： | 1 |
| 9 | Quantitation of plasma apolipoprotein J显示文摘 | Jenkins SH Stuart WD Bottoms LA | 1996 | Methods Enzymol1996，263，： | 1 |
| 10 | Effect of subgingival scaling during supportive therapy 显示文摘 | J Jenkins WM Said SH Radvar M | 2000 | Journal of Clinical Periodontology2000，27，： | 1 |
| 11 | Reciprocal pilferage and the evolution of food-hoarding behavior显示文摘 | Vander Wall SB Jenkins SH | | 0，，05： | 1 |
| 12 | Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus-their association with aneuploidy and neoplastic progression 显示文摘 | Doak SH Jenkins GJ Parry EM | 2004 | Mutat Res2004，547，12： | 1 |
| 13 | The bile acid deoxy- cholic acid (DCA) at neutral pH activates NF-kappaB and in- duces IL-$ expression in oesophageal cells in vitro 显示文摘 | Jenkins G J Harries K Doak SH | 2004 | Carcino- genesis2004，25，3： | 1 |
| 14 | The bile acid deoxycholic acid (DCA) at neutral pH activates NF- kappaB and induces IL-8 expression in oesophageal cells in vitro显示文摘 | Jenkins GJ Harres K Doak SH | 2004 | Carcinogenesis2004，25，3： | 1 |
| 15 | Activation of mitochondrial calcium-independent phospholipase A27 (iPLA27) by divalent cations mediating arachi- donate release and production of downstream eico- sanoids 显示文摘 | Moon SH Jenkins CM Liu X | 2012 | J Biol Chem2012，287，14： | 1 |
| 16 | Effect of subgingival scaling during supportive therapy显示文摘 | Jenkins WM Said SH Radvar M | 2000 | J Clin Periodontol2000，27，8： | 1 |
| 17 | Effect of subgingival scaling during supportive therapy显示文摘 | Jenkins WM Said SH Radvar M | 2000 | Clin Periodontol2000，27，8： | 1 |
| 18 | Deoxycholic acid at neutral and acid pH is genotoxic to oesoptiageal cells through the induction of ROS, The potential role of antioxidants in Barrett's oesophagus 显示文摘 | Jenkins GJ Souza FR Suzen SH | 2007 | Carcinogenesis2007，28，1： | 1 |
| 19 | Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: the potential role of anti-oxidants in Barrett' soesophagus显示文摘 | Jenkins GJ D' Souza FR Suzen SH | 2007 | Carcinogenesis2007，28，1： | 1 |
| 20 | Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer 显示文摘 | Doak SH Jenkins SA Hurle RA | 2007 | Cancer Genet Cytogenet2007，176，2： | 1 |
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