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| 1 | 短暂性脑缺血发作的定义和评价:美国心脏协会/美国卒中协会卒中委员会、心血管外科和麻醉委员会、心血管放射学和介入委员会、心血管护理委员会和外周血管病跨学科委员会对医疗卫生专业人员发布的科学声明:美国神经病学学会确认该声明作为神经科医生继续教育工具的价值显示文摘本科学声明面向为短暂性脑缺血发作(transient ischemic attacks,TIA)患者提供医疗诊治的临床医生和相关医疗卫生人员。采用正规的证据复习方法对1990-2007年7月期间Medline数据库进行系统的文献检索,并运用证据表、汇总分析和病例资料的合并分析,对数据进行综合处理。本文支持以下基于组织学的TIA定义:局灶性脑、脊髓或视网膜缺血引起的短暂性神经功能障碍发作,且无急性脑梗死。TIA患者的近期卒中风险较高,可根据临床量表、血管影像学和磁共振弥散加权成像进行风险分层。诊断推荐包括:TIA患者应在发病24h内接受神经影像学评价,最好是应用包括弥散序列在内的MRI;应进行无创性颈部血管成像检查,最好是无创性颅内血管成像;对于未能确定血管病因的患者,TIA发病后应尽快进行心电图检查,也应考虑持续心电监测和超声心动图检查;应进行常规血液化验;对于发病72h内就诊并且ABCD^2评分≥3分(提示近期复发风险较高)或在门诊不能迅速完成诊断评价的TIA患者,应收入院治疗。 | J. Donald Easton Jeffrey L. Saver Gregory W. Albers Mark J. Alberts Seemant Chaturvedi Edward Feldmann Thomas S. Hatsukami Randall T. Higashida S. Claibome Johnston Chelsea S. Kidwell Helmi L. Lutsep Elaine Miller Ralph L. Sacco 李海峰 高翔(译) | 2009 | 国际脑血管病杂志2009，，9： | 86 |
| 2 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南(续前)显示文摘7静脉溶栓
7.1静脉rtPA
急性卒中的静脉溶栓治疗现已得到普遍接受。美国FDA于1996年批准静脉应用rtPA,部分基于NINDSrtPA卒中试验结果。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，8： | 975 |
| 3 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南显示文摘背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定,代表各个领域的医疗专家。在形成共识的整个过程中,严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容,对卒中文献进行回顾,重点为前一版指南发表之后的文献,然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施,如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据,还迫切需要对急性缺血性卒中的治疗做进一步的研究。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，7： | 17 |
| 4 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 5 | 药物不良反应:定义、诊断与管理显示文摘我们将药物不良反应定义为'药物用于防治疾病而引起可以觉察到的有害的或不利的反应,这预示着继续给药会有危险,需要预防或特定治疗措施,或减少剂量,乃至停药',这样一些反应现今以世界卫生组织不良反应术语(WHO-ART)进行报告,后者终将成为国际疾病分类(ICD)的一个组成部分. | I Ralph Edwards Jeffrey K Aronson | 2001 | 药物不良反应杂志2001，3，2： | 14 |
| 6 | Does playing a sports active video game improve object control skills of children with autism spectrum disorder?显示文摘Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar age.Feasibility was a secondary aim.Methods: Actual(Test of Gross Motor Development) and perceived OC skills(Pictorial Scale of Perceived Movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was feasible.Conclusion: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities. | Jacqueline Edwards Sarah Jeffrey Tamara May Nicole J.Rinehart Lisa M.Barnett | 2017 | Journal of Sport and Health Science2017，6，1： | 12 |
| 7 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 8 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 9 | Compliance among infants exposed to hepatitis B virus in a post-vaccination serological testing program in four provinces in China显示文摘Background:Mother to child transmission of hepatitis B virus(HBV)remains the most common form of HBV infection in China.Prevention of HBV vertical transmission involves timely administration of the complete hepatitis B vaccine(HepB)series and hepatitis B immunoglobulin.Post-vaccination serological testing(PVST)is utilized to determine an infant's outcome after HBV exposure and completion of HepB series.We aim to determine the frequency of compliance with a PVST testing cascade for HBV infected mothers and analyze factors associated with infant lost to follow up(LTFU).Methods:We conducted a retrospeaive cohort review of previously collected data in Fujian,Jiangxi,Zhejiang and Chongqing provinces in China from 1 June 2016-31 December 2017.The study population included all HBV-exposed infants and their mothers.SAS software was used for statistical analyses.Bivariate and multivariate regression analyses(presented in odds ratio[OR]with 95%confidence intervals[CI])were used to compare the proportional differences of factors associated with PVST not being completed.Results:Among enrolled 8474 target infants,40%of them transferred out of the study provinces without further information and 4988 were eligible for PVST.We found 20%(994)of infants were not compliant with the testing cascade:55%of LTFU occurred because parents refused venous blood sample collection or failure of sample collection in the field,16%transferred out after 6 months of age,and 10%of families chose to have independent,confidential PVST completed without reporting results.High PVST noncompliance rates were more likely to be from Fujian(aOR=17.0,95%CI:9.7-29.9),Zhejiang(aOR=5.7,95%Cl:3.2-10.1)and Jiangxi(aOR=1.9,95%CI:1.0-3.4),and from HBV e antigen positive mother(aOR=1.2,95%CI:1.1-1.4).Conclusions:This study found that the LTFU rate reached 20%in PVST program,which was a significant problem.We recommend implementing a national elearonic information system for tracking HBV at risk mother-infant pairs;encourage further research in developing a less invasive means of completing PVST,and take effective measures nationally to reduce HBV stigma.Without reducing the loss to follow up rate among infants eligible for PVST,elimination of vertical HBV transmission will be impossible. | Hui Zheng Guo-Min Zhang Po-Lin Chan Fu-Zhen Wang Lance Everett Rodewald Ning Miao Xiao-Jin Sun Zun-Dong Yin Jeffrey Edwards Hua-Qing Wang | 2019 | Infectious Diseases of Poverty2019，8，4： | 5 |
| 10 | Change patterns of oncomelanid snail burden in areas within the Yangtze River drainage after the three gorges dam operated显示文摘Background:An'integrated control'strategy has been implemented within seven provinces at highest risk for schistosomiasis along Yangtze River in Peoples'Republic of China(P.R.China)since 2004.Since O ncom elania hupensis is the only intermediate host of the blood fluke(Schistosom a japonicum),controlling the distribution of snails is considered an essential and effeaive way to reduce the risk of schistosomiasis infection.The study aimed to determine the snail area burden and annual trend among provinces with potential risk for schistosomiasis along the Yangtze River,above and below the Three Gorges Dam(TGD).Methods:This retrospective study utilized data previously collected from the National Parasitic Diseases Control Information Management System(NPDCIMS)on annual snail surveys from 2009 to 2017.Descriptive statistics were performed for analyzing the snail burden by provinces,counties,type of environmental location and year,and mapping was conducted to present the snails distribution.Results:From 2009 to 2017,the total snail infested area decreased by 4.22%,from 372253 hm^2 to 356553 hm^2 within the seven high risk provinces.The majority of snails were found in the marshland and lake regions,outside of control embankments.The total snail burden trend remained relatively stable in upstream regions above the TGD from 2010 to 2015,while the trend decreased within downstream regions during this period.In 2016 and 2017,the total snail burden trend increased in both upstream and downstream provinces,however,upstream saw a larger increase.From 2009 to 2017,there were a total of 5990 hm^2 of newly developed snail areas in the seven study provinces and the majority were concentrated in regions below the TGD,accounting for 5610 hm^2(93.70%).Conclusions:There has been a decline in total snail counts from 2009 to 2017.Meanwhile,new snail breeding areas were formed mainly within provinces downstream the TGD due to spread of snails,indicated that the oncomelanid snail would be difficult to completely eliminate.We suggest that the national schistosomiasis integrated control strategy,including mollusciding and environmental modification,will need to be enhanced significantly going forward to achieve a greater reduaion in snail burden and ultimately to achieve elimination. | Si-Min Dai Jeffrey Edwards Zhou Guan Shan Lv Shi-Zhu Li Li-Juan Zhang Jun Feng Ning Feng Xiao-Nong Zhou Jing Xu | 2019 | Infectious Diseases of Poverty2019，8，3： | 4 |
| 11 | A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers显示文摘 | Katsuhiko Nosho Shoko Kure Natsumi Irahara Kaori Shima Yoshifumi Baba Donna Spiegelman Jeffrey A. Meyerhardt Edward L. Giovannucci Charles S. Fuchs Shuji Ogino | 2009 | Gastroenterology2009，，5： | 4 |
| 12 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 13 | 美国国家卒中协会对短暂性脑缺血发作诊治体系的推荐意见显示文摘短暂性脑缺血发作(transient ischemic attack,TIA)很常见,预示短期卒中风险很高。有关TIA患者紧急评价和治疗的循证推荐意见已经发表。然而,这些推荐意见的可靠和一致的执行需要对现有TIA诊治体系做出相应的改变。美国国家卒中协会召集了一个多学科专家小组,提出了医院内TIA诊治体系主要内容的推荐意见,以提高对TIA患者的诊疗质量。专家小组推荐医院制定标准化方案,以确保对TIA患者实施快速和完整的评价和处理,特别关注对卒中高危患者进行紧急而密切的观察。 | S. Claibome Johnston Gregory W. Albers Philip B. Gorelick Ethan Cumbler Jeffrey Klingman Michael A. Ross Meg Brisgs Jean Carlton Edward P. Sloan Uzma Vaince 李海峰(译) 洪宇(译) 王琦(译) | 2011 | 国际脑血管病杂志2011，19，9： | 3 |
| 14 | Rescheduling Manufacturing Systems: A Framework of Strategies, Policies, and Methods显示文摘 | Guilherme E. Vieira Jeffrey W. Herrmann Edward Lin | 2003 | Journal of Scheduling2003，，1： | 2 |
| 15 | <ce:link locator='fx1'/> Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation显示文摘 | Edward J. Gane Peter W. Angus Simone Strasser Darrell H.G. Crawford John Ring Gary P. Jeffrey Geoffrey W. McCaughan | 2007 | Gastroenterology2007，，3： | 2 |
| 16 | Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor显示文摘 | Edward J. Filardo Jeffrey A. Quinn Edmond Sabo | 2008 | Steroids2008，，9： | 2 |
| 17 | Discovery of the butenyl-spinosyn insecticides: Novel macrolides from the new bacterial strain Saccharopolyspora pogona显示文摘 | Paul Lewer Donald R. Hahn Laura L. Karr Dennis O. Duebelbeis Jeffrey R. Gilbert Gary D. Crouse Thomas Worden Thomas C. Sparks Pat McKamey Rex Edwards Paul R. Graupner | 2009 | Bioorganic & Medicinal Chemistry2009，，12： | 1 |
| 18 | Trends in Hypertension Prevalence, Awareness, Treatment, and Control Rates in United States Adults Between 1988–1994 and 1999–2004显示文摘 | Jeffrey A. Cutler Paul D. Sorlie Michael Wolz Thomas Thom Larry E. Fields Edward J. Roccella | 2008 | Hypertension2008，，5： | 1 |
| 19 | Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation显示文摘 | Edward J. Gane Peter W. Angus Simone Strasser Darrell H.G. Crawford John Ring Gary P. Jeffrey Geoffrey W. McCaughan | 2007 | Gastroenterology2007，，3： | 1 |
| 20 | Work and Family Stress and Well-Being: An Examination of Person-Environment Fit in the Work and Family Domains显示文摘 | Jeffrey R Edwards Nancy P Rothbard | 1999 | Organizational Behavior and Human Decision Processes1999，，2： | 1 |
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