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3篇 您的检索式:作者名="Jayaveera KN"
    题名 作者 年代 出处 被引量
1Antioxidant and antipyretic properties of methanolic extract of Amaranthus spinosus leaves显示文摘Objective:Methanolic extract of Amaranthus spinosus(A.spinosus) leaves was screened for antioxidant and antipyretic activities.Methods:Antioxidant activity was measured by l,l-diphenyl-2-picryl-hydrazile(DPPH) free radical scavenging,superoxide anion radical scavenging,hydroxyl free radical scavenging,nitric oxide radical scavenging,2,2 -azinobis-3- ethylbenzothiazole-6-sulfonic acid(ABTS) radical scavenging assays and total phenolic content was also determined.Antipyretic activity of methanolic extract of A.spinosus was measured by yeast induced pyrexia method at concentration of 200 and 400 mg/kg using paracetamol as standard drug.Results:Methanolic extract of A.spinosus showed potent antioxidant activity.The IC50 value was(87.50±3.52)μg/mL,(98.80±1.40)μg/mL,(106.25±0.20)μg/mL,(88.70±0.62)μg/mL and(147.50±2.61)μg/mL for DPPH,superoxide,hydroxyl,nitric oxide and ABTS radical scavenging activities.Methanolic extract of A spinosus showed significant(P<0.01) antipyretic activity.Bagepalli Srinivas Ashok Kumar Kuruba Lakshman Jayaveera KN Devangam Sheshadri Shekar Avalakondarayappa Arun Kumar Bachappa Manoj 2010Asian Pacific Journal of Tropical Medicine2010,3,9:15
2Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae显示文摘Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(A.caudatus) and Amaranthus spinosus(A.spinosus).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for mice.Results:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of A.viridis,A.caudatus and A.spinosus show potent analgesic activities,and this study provides the scientific proof for their traditional claims.Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM 2010Asian Pacific Journal of Tropical Medicine2010,3,7:2
3Quantification of ibuprofen in human plasma by using high throughput liquid chromatography-tandem mass spectrometric method and its applications in pharmacokinetics显示文摘Raghunadha RS Sarath chandiran I Jayaveera KN 0,,03:1
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