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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Free-breathing radial volumetric interpolated breathhold examination vs breath-hold cartesian volumetric interpolated breath-hold examination magnetic resonance imaging of the liver at 1.5T显示文摘AIM: To compare breath-hold cartesian volumetric interpolated breath-hold examination(cVIBE) and freebreathing radial VIBE(rVIBE) and determine whether rVIBE could replace cVIBE in routine liver magnetic resonance imaging(MRI).METHODS: In this prospective study, 15 consecutive patients scheduled for routine MRI of the abdomen underwent pre- and post-contrast breath-hold cVIBE imaging(19 s acquisition time) and free-breathing rVIBE imaging(111 s acquisition time) on a 1.5T Siemens scanner. Three radiologists with 2, 4, and 8 years post-fellowship experience in abdominal imaging evaluated all images. The radiologists were blinded to the sequence types, which were presented in a random order for each patient. For each sequence, the radiologists scored the cVIBE and rVIBE images for liver edge sharpness, hepatic vessel clarity, presence of artifacts, lesion conspicuity, fat saturation, and overall image quality using a five-point scale. RESULTS: Compared to rVIBE, cVIBE yielded significantly(P < 0.001) higher scores for liver edge sharpness(mean score, 3.87 vs 3.37), hepatic-vessel clarity(3.71 vs 3.18), artifacts(3.74 vs 3.06), lesion conspicuity(3.81 vs 3.2), and overall image quality(3.91 vs 3.24). cVIBE and rVIBE did not significantly differ in quality of fat saturation(4.12 vs 4.03, P = 0.17). The inter-observer variability with respect to differences between rVIBE and cVIBE scores was close to zero compared to random error and inter-patient variation. Quality of rVIBE images was rated as acceptable for all parameters. CONCLUSION: rVIBE cannot replace cVIBE in routine liver MRI. At 1.5T, free-breathing rVIBE yields acceptable, although slightly inferior image quality compared to breath-hold cVIBE. | Sireesha Yedururi HyunSeon C Kang Wei Wei Nicolaus A Wagner-Bartak Leonardo P Marcal R Jason Stafford Brandy J Willis Janio Szklaruk | 2016 | World Journal of Radiology2016，8，7： | 9 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 5 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 6 | Solvent-resistant photocurable“liquid teflon”for microfluidic device fabrication显示文摘 | Jason P Rolland R Michael Van Dam Derek A Schorzman | 2004 | Journal of the American Chemical Society2004，126，8： | 1 |
| 7 | Chronic fatigue syndrome,chronic fatigue,and psychiatric disorders: pre- dictors of functional status in a national nursing sample 显示文摘 | Wagner L I Jason L A Ferrari J R | 1999 | J Occup Health Psychol1999，4，1： | 1 |
| 8 | Emeishan large igneous province,SW China显示文摘 | Jason R A Thompson G M Zhou Meifu | 2005 | Lithos2005，79，： | 1 |
| 9 | Ipilimumab forpatients with advanced mucosal melanoma 显示文摘 | Michael A P Jason J L Ma r k J B | 2013 | Oncologist2013，18，6： | 1 |
| 10 | Arthroscopic debridement for the treatment of osteoarthritis of knee:2 and 5 year results显示文摘 | Jason F Dennis R Sohail A | 2002 | Arthroscopy2002，18，8： | 1 |
| 11 | Chem Mater显示文摘 | OarMichael A Serin Jason M Dichtel William R and FréchetJean M J | 2005 | 17:2267-22752005，17，： | 1 |
| 12 | A role for the adenomatous polyposis coil protein in chromosome segregation 显示文摘 | KENNETH B K AURORA A B JASON R S | 2001 | Nat Cell Biol2001，3，4： | 1 |
| 13 | Toxic activity from cultures of Karlodinium micrum (Gyrodinium galatheanum ) (Dinophyceae)-a dinoflagellate associated with fish mortalities in an estuarine aquaculture facility显示文摘 | Jonathan R D Daniel E T Jason E A | 2002 | Harmful Algae2002，1，： | 1 |
| 14 | Fatigue rating scales: an empirical comparison 显示文摘 | Taylor R Jason L Torres A | 2000 | Psychol Med2000，30，4： | 1 |
| 15 | Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/ lpr mice显示文摘 | Knight Jason S Subramanian Venkataraman O’Dell Alexander A Yalavarthi Srilakshmi Zhao Wenpu Smith Carolyne K Hodgin Jeffrey B Thompson Paul R Kaplan Mariana J | 2015 | Annals of the Rheumatic Diseases2015，，： | 1 |
| 16 | Chronic fatigue syndrome,chronic fatigue,and psychiatric disorders:predictors of functional status in a national nursing sample显示文摘 | WAGNER-RAPHAEL L I JASON L A FERRARI J R | | 0，，01： | 1 |
| 17 | X-Ray Absorp-tion Fine Structure Characterization of the Local Structure ofFe in Fe-ZSM-5 显示文摘 | Sun H C Benjamin R W Jason A R | 2003 | J Phys Chem B2003，107，11： | 1 |
| 18 | SCR catalyst performance in flue gases derived from subbituminous and lignite coals 显示文摘 | STEVEN A B JASON D L CHARLENE R C | 2005 | Fuel Processing Technology2005，86，： | 1 |
| 19 | Retained surgical sponge simulating a pancreatic mass 显示文摘 | Jason R S Chisolm A Lubetsky H W | 1979 | J Natl Med Assoc1979，71，5： | 1 |
| 20 | Autonomous mobile robot global motion planning and geometric beacon collection using transversability vectors显示文摘 | Janet Jason A R C Luo M G Kay | 1997 | IEEE Transactions on Robotics and Automation1997，13，1： | 1 |
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