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| 1 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 2 | Optimization and implementation of periodic cruise for a hypersonic vehicle 显示文摘 | Chen Robert H Williamson Walton R Speyer Jason L | 2006 | Journal of Guidance Control and Dynamics2006，29，5： | 1 |
| 3 | Combing new technologies for determination of phytoplankton community structure in the northern gulf of Mexico显示文摘 | JASON H S LISA C TAMMI L R | 2005 | Journal Plankton2005，41，： | 1 |
| 4 | Osteomyelitis in Long Boneb显示文摘 | Lazzarini L Mader JT Jason H | 2004 | Bone Jont Surg2004，86，： | 1 |
| 5 | Loss of INI 1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma显示文摘 | Jason H L Paola D C Christopher F D M | 2009 | Am J Surg Pathol2009，33，4： | 1 |
| 6 | Cytoreductive Surgery with Intraperitoneal Hyperthermic Chemotherapy for advanced Cancer显示文摘 | Jason J H Brian W L Parry S | 2004 | The Society for Surgery of the Alimentary Tract2004，8，4： | 1 |
| 7 | Homing missile guidance and estimation under agile target acceleration 显示文摘 | CHEN R H JASON L S | 2007 | Journal of Guidance Control and Dynamic2007，30，6： | 1 |
| 8 | Osteoporotie pertroehanterie hip fractures managenrnent and current controversies 显示文摘 | DEAN G L DAVID S G JASON H N | 2004 | J Bone Joint Surg(Am)2004，2，： | 1 |
| 9 | The importance of preoperative Hemoglobin Evaluation in large volume liposuction 显示文摘 | Umar H C Petr H Jason L | 2008 | Ann Plast Surg2008，61，3： | 1 |
| 10 | Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons显示文摘 | HOA H L EMILY M C JASON P C | 2008 | Toxicology Letters2008，176，2： | 1 |
| 11 | Role of disinfectant concentration and pH in the inactivation kinetics of Cryptosporidium parvum oocysts with ozone and monochloramlne 显示文摘 | Jason L R Jae H K Benito C V | 2001 | Environmental Science and Technology2001，35，13： | 1 |
| 12 | High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson's disease显示文摘 | Dominik H Purnat TD Jason L | 2007 | J Biol Chem2007，282，： | 1 |
| 13 | Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy显示文摘Background The number of mobile stroke programmes has increased with evidence,showing they expedite intravenous thrombolysis.Outstanding questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical outcomes.Objective Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October 2018.We reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical outcomes.Results Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(p<0.001).Seven MSU patients(12%)received tPA from 3.5 hours to 4.5 hours since last known well and would likely have been outside the window with EMS care.Endovascular thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(ET)at 133.0 min(±37.0)(p=0.0002).There was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal variable.Conclusions Mobile stroke care expedited both intravenous thrombolysis and endovascular thrombectomy.There is an ongoing need to show improved functional outcomes with MSU care. | Matthew T Bender Thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy T Cushman Webster H Pilcher Curtis G Benesch Adam G Kelly Tarun Bhalla | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 14 | Optimal Gaussian entanglement swapping显示文摘 | Jason H O Peter V L | 2011 | Physical Review A2011，83，01： | 1 |
| 15 | Rural drinking water at supply and household levels: Quality and management显示文摘 | Bilqis A Kelly H Jason L | 2006 | International Journal of Hygiene and EnvironmentalHealth2006，209，5： | 1 |
| 16 | Solid-supported cyclohexane-1,3-dione (CHD):A' capture and release'reagent for thesynthesis of amides and novel scavenger resin显示文摘 | Cara E H Morag A M E Jason P T et a l | 2003 | Org Lett2003，5，6： | 1 |
| 17 | On robust stabilization of uncertain stochastic time - delay systems: an LMI - based approach 显示文摘 | Chienyu L Tejen S Jason S H T | 2005 | J Franklin Institute2005，342，5： | 1 |
| 18 | A Vehicle Health Monitoring System Evaluated Experimentally on a Passenger Vehicle 显示文摘 | HOK K NG ROBERT H CHEN JASON L SPEYER | 2006 | IEEE Trans Control Systems Technology2006，14，5： | 1 |
| 19 | Peanuts, peanut oil, and fat free peanut flour reduced cardiovascular disease risk factors and the development of atherosclerosis in syrian golden hamsters 显示文摘 | Amanda M Stephens Lisa L Dean Jack P Davis Jason A Osborne Timothy H Sanders | 2010 | Journal of Food Science2010，75，4： | 1 |
| 20 | Gastrointestinal stromal tumours: from KIT to succinate dehydrogenase显示文摘 | Leona A D Jason L H | 2014 | Histopathology2014，64，1： | 1 |
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