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| 1 | 大气环境卫星温室气体和气溶胶协同观测综述显示文摘人类排放的温室气体和气溶胶是造成全球气候变暖和大气环境恶化的主要因素,也是大气环境卫星遥感的核心探测目标。与传统的单一探测目标卫星相比,实现同平台的大气温室气体和气溶胶协同监测,对于提高温室气体卫星反演精度、改善“自上而下”碳源汇估算、提升温室气体和气溶胶的人为/自然源区分能力具有重要意义,也是各国航天机构积极发展的空间探测手段。本文对欧、日、中、美等具备温室气体和气溶胶协同监测能力的卫星进行系统的介绍,包括卫星平台、传感器、处理算法和质控验证。按照卫星监测任务和传感器用途,将其分为大气综合探测卫星和温室气体监测卫星两大类,并从碳中和行动和大气环境综合治理等需求出发,提出温室气体和气溶胶协同观测星座(GACOC)的概念及其发展方向,包括主被动卫星组网观测、温室气体和气溶胶高精度联合反演算法、人为排放源识别和定量监测等应用。 | 李正强 谢一凇 石玉胜 厉青 Cohen Jason 张羽中 韩颖慧 熊伟 刘毅 | 2022 | 遥感学报2022，26，5： | 8 |
| 2 | 基于涡动及走航观测的晋东南煤矿区甲烷分布特征显示文摘甲烷是仅次于二氧化碳的全球第二大温室气体,在大气中的寿命仅为10 a左右,但其全球增温潜势却是CO_(2)的几十倍。大气中的甲烷体积分数可以更加迅速地对温室减排活动做出响应,相较于CO_(2)减排,控制和减少甲烷排放是短期内应对气候变化的最有效手段之一。煤炭开采行业是我国甲烷的最主要排放源之一。在碳达峰和碳中和的国家战略需求下,控制和利用煤炭活动产生的甲烷排放,必将成为“十四五”期间我国甲烷排放控制行动的重点,厘清煤矿行业的甲烷排放特征具有重要意义。煤炭开采活动产生的甲烷排放受到地质赋存、开采方式、利用情况等众多因素影响,传统的“自下而上”排放因子清单方法不确定性较大,基于大气甲烷体积分数观测数据的“自上而下”技术正成为监测核算甲烷排放的重要方法。2021年秋冬季,采用“固定+走航”相结合的观测手段,以我国典型的甲烷高排放区(晋东南煤矿区)为实验区域,获取一手观测数据,分析并揭示近地面甲烷体积分数特征及其潜在的排放源信息。结果表明:(1)甲烷体积分数的时空变化性强,煤矿区本底甲烷体积分数值是清洁本底的近1.7倍,极端高值可达本底值的40~50倍;(2)甲烷体积分数在1 d内的变化与煤炭生产活动密切相关,逐日变化受气象扩散条件影响较大;(3)绝大多数甲烷体积分数高值位于煤矿生产相关区域,但由于扩散作用的影响,煤炭生产对甲烷体积分数时空分布影响存在一定的空间偏离性和时间滞后性。地面“固定+走航观测”手段可以提供精细化的甲烷排放特征信息,研究结论可为基于观测“自上而下”地构建煤炭行业甲烷排放清单奠定一定基础。 | 刘艳秋 秦凯 COHEN Blake Jason 康涵书 胡玮 鹿凡 武晓晖 杨成立 | 2022 | 煤炭学报2022，47，12： | 2 |
| 3 | The use of a standardized Chinese herbal formula in patients with advanced lung cancer:a feasibility study显示文摘Objective: Increasing numbers of cancer patients are using Chinese herbs(CHs). However, differences among prior studies make it difficult to draw firm conclusions about the clinical usefulness of any specific CH formula. The primary objective of this study was to establish the acceptability of taking a standardized CH formula for patients with advanced lung cancer. The secondary objective was to identify any toxicities attributable to this CH formula and to measure changes in quality of life.Methods: A single-arm, prospective study of a 6-week intervention with a selected CH formula in15 patients with stage 4 nonsmall-cell lung cancer(NSCLC, Seventh American Joint Committee on Cancer TNM staging system).Results: Patients with advanced lung cancer were interested in using the CH formula. Completion(93%)and adherence(98%) levels were very high and most patients perceived the CH treatment as easy to take and were willing to take the CHs used in the study again if it was available. About half of the patients reported adverse events, all of which were mild(Grade 1 or 2) and only a small minority(8%) were potentially related to CHs. No biochemical or hematological evidence of toxicity was observed. Overall, there were improvement in quality of life, and reduced feelings of tiredness and sleepiness.Conclusion: This study provides preliminary evidence that short-term use of a carefully selected and prepared CH formula in patients with stage 4 NSCLC is acceptable and safe. | Goulnar Kasymjanova Anh-Thi Tran Victor Cohen Carmela Pepe Lama Sakr David Small Jason Scott Agulnik Robert Thomas Jagoe | 2018 | Journal of Integrative Medicine2018，16，6： | 2 |
| 4 | Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors显示文摘 | Masayuki Fukata Anli Chen Arunan S. Vamadevan Jason Cohen Keith Breglio Suneeta Krishnareddy David Hsu Ruliang Xu Noam Harpaz Andrew J. Dannenberg Kotha Subbaramaiah Harry S. Cooper Steven H. Itzkowitz Maria T. Abreu | 2007 | Gastroenterology2007，，6： | 1 |
| 5 | Implanted adipose progenitor cells as physicochemical regulators of breast cancer显示文摘 | Emily M. Chandler Bo Ri Seo Joseph P. Califano Roberto C. Andresen Eguiluz Jason S. Lee Christine J. Yoon David T. Tims James X. Wang Le Cheng Sunish Mohanan Mark R. Buckley Itai Cohen Alexander Yu Nikitin Rebecca M. Williams Delphine Gourdon Cynthia A. R | 2012 | Proceedings of the National Academy of Sciences2012，，25： | 1 |
| 6 | Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions显示文摘Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. Comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/mL and flow rate of 1.0μL/min had the best recovery. A concentration of 5.0μg/mL and flow rate of 1.0μL/min yielded maximal recovery for vancomycin. Large molecular size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. Low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations. | Jayesh A.Dhanani Suzanne L.Parker Jeffrey Lipman Steven C.Wallis Jeremy Cohen John Fraser Adrian Barnett Michelle Chew Jason A.Roberts | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 1 |
| 7 | Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function显示文摘 | Pavan Atluri Jordan S. Miller Robert J. Emery George Hung Alen Trubelja Jeffrey E. Cohen Kelsey Lloyd Jason Han Ann C. Gaffey John W. MacArthur Christopher S. Chen Y. Joseph Woo | 2014 | The Journal of Thoracic and Cardiovascular Surgery2014，，3： | 1 |
| 8 | Training guideline for use of propofol in gastrointestinal endoscopy显示文摘 | Robynne Chutkan Jonathan Cohen Mahmood Abedi Marcia Cruz-Correa Jason Dominitz Keith Gersin David Greenwald Sergey Kantsevoy Kris Kowdley Michelle Nguyen Roy Soetikno Jennifer Telford John Vargo | 2004 | Gastrointestinal Endoscopy2004，，2： | 1 |
| 9 | Vegetation-related dry deposition of global PM_(2.5) from satellite observations显示文摘Vegetation plays an important role in the dry deposition of particles with significant spatial variability,but the magnitude remains unclear at the global scale.With the aid of satellite products,this study estimated the vegetation-related dry deposition of fine particulate matter(PM_(2.5)).Methodologically,dry deposition was first calculated using an empirical algorithm.Then,deposition on the leaf surface was estimated to evaluate the influence of vegetation.Our results showed that the mean deposition velocity(V_(d))of global PM_(2.5)was 0.91×10^(-3)μg·m^(-2)·s^(-1),with high velocities observed in sparsely vegetated regions because of the high friction velocity.Under the combined effect of the PM_(2.5)mass concentration and deposition velocity,the global mean dry deposition reached 0.47 g·m-^(2)·yr^(-1).Global vegetation absorbed 0.26 g·m-^(2)·yr^(-1)from PM_(2.5)pollution sources,contributing 54.98%of the total dry deposition.Spatially,vegetation-related dry deposition was high in the Amazon,Central Africa and East China due to dense vegetation coverage or serious pollution.Temporally,the increasing trends were mainly in Central Africa and India because of worsening air pollution.The results of this study helped to clarify the impact of vegetation on air pollution,which supported related land management and planning for air quality improvement. | FENG Huihui DING Ying ZOU Bin COHEN Jason Blake YE Shuchao YANG Zhuolin QIN Kai LIU Lei GU Xiaodong | 2022 | Journal of Geographical Sciences2022，32，4： | 1 |
| 10 | Satellite remote sensing of atmospheric particulate matter mass concentration:Advances,challenges,and perspectives显示文摘Mapping the mass concentration of near-surface atmospheric particulate matter(PM)using satellite observations has become a popular research niche,leading to the development of a variety of instruments,algorithms,and datasets over the past two decades.In this study,we conducted a holistic review of the major advances and challenges in quantifying PM,with a specific focus on instruments,algorithms,datasets,and modeling methods that have been developed over the past 20 years.The aim of this study is to provide a general guide for future satellite-based PM concentration mapping practices and to better support air quality monitoring and management of environmental health.Specifically,we review the evolution of satellite platforms,sensors,inversion algorithms,and datasets that can be used for monitoring aerosol properties.We then compare various practical methods and techniques that have been used to estimate PM mass concentrations and group them into four primary categories:(1)univariate regression,(2)chemical transport models(CTM),(3)multivariate regression,and(4)empirical physical approaches.Considering the main challenges encountered in PM mapping practices,for example,data gaps and discontinuity,a hybrid method is proposed with the aim of generating PM concentration maps that are both spatially continuous and have high precision. | Ying Zhang Zhengqiang Li Kaixu Bai Yuanyuan Wei Yisong Xie Yuanxun Zhang Yang Ou Jason Cohen Yuhuan Zhang Zongren Peng Xingying Zhang Cheng Chen Jin Hong Hua Xu Jie Guang Yang Lv Kaitao Li Donghui Li | 2021 | Fundamental Research2021，1，3： | 0 |
| 11 | 体质量稳定及肠外营养特征与结直肠癌患者预后的相关性显示文摘背景:代谢紊乱及肠外营养(PN)特征对接受肠外营养的癌症患者生存的影响,目前所知有限。本研究旨在评估临床方法:研究纳入美国MD Anderson癌症中心2008-2013年接受肠外营养支持的572例结直肠癌患者。记录病例特征、体质指数、体质量、药物/手术治疗史、PN适应证、PN相关数据及生存情况。分析临床及PN特征与患者生存的相关性。结果:437例患者纳入最终分析,平均年龄57岁,81%为进展期结直肠癌。经多因素校正后,PN开始前体质量不稳定(变化≥2.5%)与生存负相关(HR=1.41,P=0.023)。肠梗阻作为PN适应证者较无肠梗者预后更差(HR=1.75,P=0.017)。PN配方中每千克理想体质量的氨基酸含量(g/kg)更高者,其生存时间更长(HR=0.59,P=0.029);而非PN配方中的静脉卡路里摄入量更高者,其生存时间更短(HR=1.04,P=0.011)。结论:体质指数和体质量稳定可能是预测接受PN支持的结直肠癌患者预后的有效营养学指标。制定PN计划时应考虑到非PN卡路里的摄入量,从而获得最佳的能量支持和能量平衡。进一步研究需明确PN配方中最优的氨基酸需求量和能量平衡。 | Wenli Liu Aiham Qdaisat Eric Lee Jason Yeung Khanh Vu Jun-Zhong Lin Todd Canada Shouhao Zhou Lorenzo Cohen Eduardo Bruera Sai-Ching J.Yeung | 2019 | Gastroenterology Report2019，7，6： | 0 |
| 12 | Dramatic decline of observed atmospheric CO_(2) and CH_(4) during the COVID-19 lockdown over the Yangtze River Delta of China显示文摘The temporal variation of greenhouse gas concentrations in China during the COVID-19 lockdown in China is analyzed in this work using high resolution measurements of near surface ΔCO_(2),ΔCH_(4) andΔCO concentrations above the background conditions at Lin’an station(LAN),a regional background station in the Yangtze River Delta region.During the pre-lockdown observational period(IOP-1),bothΔCO_(2) andΔCH_(4) exhibited a significant increasing trend relative to the 2011-2019 climatological mean.The reduction ofΔCO_(2),ΔCH_(4) andΔCO during the lockdown observational period(IOP-2)(which also coincided with the Chinese New Year Holiday)reached up to 15.0 ppm,14.2 ppb and 146.8 ppb,respectively,and a reduction ofΔCO_(2)/ΔCO probably due to a dramatic reduction from industrial emissions.ΔCO_(2),ΔCH_(4) and ΔCO were observed to keep declining during the post-lockdown easing phase(IOP-3),which is the synthetic result of lower than normal CO_(2) emissions from rural regions around LAN coupled with strong uptake of the terrestrial ecosystem.Interestingly,the trend reversed to gradual increase for all species during the later easing phase(IOP-4),with ΔCO_(2)/ΔCO constantly increasing from IOP-2 to IOP-3 and finally IOP-4,consistent with recovery in industrial emissions associated with the staged resumption of economic activity.On average,ΔCO_(2) declined sharply throughout the days during IOP-2 but increased gradually throughout the days during IOP-4.The findings showcase the significant role of emission reduction in accounting for the dramatic changes in measured atmosphericΔCO_(2) and ΔCH_(4) associated with the COVID-19 lockdown and recovery. | Miao Liang Yong Zhang Qianli Ma Dajiang Yu Xiaojian Chen Jason Blake Cohen | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
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