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| 1 | High incidence of postoperative bowel obstruction in newborns and infants显示文摘 | Janet YY Daniel SK Christopher SM | | 0，，06： | 1 |
| 2 | Endoscopic submucosal dissection vs laparoscopic colorectal resection for early colorectal epithelial neoplasia显示文摘AIM: To compare the short term outcome of endoscopic submucosal dissection(ESD) with that of laparoscopic colorectal resection(LC) for the treatment of early colorectal epithelial neoplasms that are not amenable to conventional endoscopic removal. METHODS: This was a retrospective cohort study. The clinical data of all consecutive patients who underwent ESD for endoscopically assessed benign lesions that were larger than 2 cm in diameter from 2009 to 2013 were collected. These patients were compared with a cohort of controls who underwent LC from 2005 to 2013. Lesions that were proven to be malignant by initial endoscopic biopsies were excluded. Mid and lower rectal lesions were not included because total mesorectal excision, which bears a more complicated postoperative course, is not indicated for lesions without histological proof of malignancy. Both ESD and LC were performed by the same surgical unit with a standardized technique. The patients were managed according to a standard protocol, and they were closely monitored for complications after the procedures. All hospital records were reviewed, and the following data were compared between the ESD and LC groups: patient demographics, size and location of the lesions, procedure time, shortterm clinical outcomes and pathology results. RESULTS: From 2005 to 2013, 65 patients who underwent ESD and 55 patients who underwent LC were included in this study. The two groups were similar in terms of sex(P = 0.41) and American Society of Anesthesiologist class(P = 0.58), although patients in the ESD group were slightly older(68.6 ± 9.4 vs 64.6 ± 9.9, P = 0.03). ESD could be accomplished with a shorter procedure time(113 ± 66 min vs 153 ± 43 min, P < 0.01) for lesions of comparable size(3.0 ± 1.2 cm vs 3.4 ± 1.4 cm, P = 0.22) and location(colon/rectum:59/6 vs colon/rectum: 52/3, P = 0.43). ESD appeared to be associated with a lower short-term complication rate, but the difference did not reach statistical significance(10.8% vs 23.6%, P = 0.06). In the LC arm, a total of 22 complications occurred in 13 patients. A total of 7 complications occurred in the ESD arm, including 5 perforations and 2 episodes of bleeding. All perforations were observed during the procedure and were successfully managed by endoscopic clipping without emergency surgical intervention. Patients in the ESD arm had a faster recovery than patients in the LC arm, which included shorter time to resume normal diet(2 d vs 4 d, P = 0.01) and a shorter hospital stay(3 d vs 6 d, P < 0.01). CONCLUSION: ESD showed better short-term clinical outcomes in this study. Further prospective randomized studies will be required to evaluate the efficacy and superiority of colorectal ESD over LC. | Sophie SF Hon Simon SM Ng Tiffany CL Wong Philip WY Chiu Tony WC Mak WW Leung Janet FY Lee | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 1 |
| 3 | Regional metabolic effects of fluoxetine in major depression: serial changes and relation -ship to clinical response 显示文摘 | Steven KB Janet LT | 2000 | Biol Psychiatry2000，48，： | 1 |
| 4 | Step Test scores are related to measures of activity and participation in the first 6 months after stroke 显示文摘 | Vicki SM Janet KF Chang SH | 2009 | Physical Therapy2009，89，10： | 1 |
| 5 | Quantitative Magnetic Resonance Imaging of Fuyu Persimmon Fruit During Development and Ripening显示文摘 | Christopher JC Janet SM | 2003 | Magnetic Resonance Imaging2003，21，： | 1 |
| 6 | Magnetic Resonance Imaging of Persimmon Fruit during Storage at low Temperature and under Modified Atmosphere显示文摘 | Christopher JC Janet SM | 1996 | Postharvest Biology and Technology1996，28，： | 1 |
| 7 | Sta bility of cef-tazidime(with arginine) st ored in plastie syringes at shree tem-pe ratures显示文摘 | Milap CN Richard SM Janet LF | 1992 | Am J Hosp Phatm1992，49，12： | 1 |
| 8 | Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial显示文摘 | Ka Lau Leung Samuel PY Kwok Steve CW Lam Janet FY Lee Raymond YC Yiu Simon SM Ng Paul BS Lai Wan Yee Lau | 2004 | 2004 (9416)2004，，9416： | 1 |
| 9 | Acupuncture transcutaneous electrical nerve stimulation reduces discomfort associated with barostat-induced rectal distension:A randomized-controlled study显示文摘AIM:To explore the effectiveness of acupuncture transcutaneous electrical nerve stimulation(Acu-TENS), a non-invasive modality in reduction of rectal discomfort during barostat-induced rectal distension. METHODS:Forty healthy subjects were randomized to receive 45 min of either Acu-TENS or placebo-TENS(no electrical output)over acupuncture points Hegu(largeintestine 4),Neiguan(pericardium 6)and Zusanli(stomach 36).A balloon catheter attached to a dual-drive barostat machine was then inserted into the subjects'rectum.A step-wise(4 mmHg)increase in balloon pressure was induced until maximal tolerable or 48 mmHg.Visual analogue scale and a 5-point subjective discomfort scale(no perception,first per-ception of distension,urge to defecate,discomfort/ pain and extreme pain)were used to assess rectal discomfort at each distension pressure.Blood beta-endorphin levels were measured before,immediately after intervention,at 24 mmHg and at maximal toler- able distension pressure. RESULTS:There was no difference in the demographic data and baseline plasma beta-endorphin levels between the two groups.Perception threshold levels were higher in the Acu-TENS group when compared to the placebo group,but the difference reached statistical significance only at the sensations'urge to defecate'and'pain'.The distension pressures recorded at the'urge to defecate'sensation for the Acu-TENS and placebo-TENS groups were 28.0±4.5 mmHg and 24.6±5.7 mmHg,respectively(P=0.043);and the pressures recorded for the'pain'sensation for these two groups were 36.0±4.2 mmHg and 30.5± 4.3 mmHg respectively(P=0.002).Compared to the placebo group,a higher number of participants in the Acu-TENS group tolerated higher distension pressures (>40 mmHg)(65%in Acu-TENS vs 25%in placebo, P=0.02).The plasma beta-endorphin levels of the Acu-TENS group were significantly higher than that of the placebo group at barostat inflation pressure of 24 mmHg(1.31±0.40 ng/mL vs 1.04±0.43 ng/mL,P= 0.044)and at maximal inflation pressure(1.46±0.53 ng/mL vs 0.95±0.38 ng/mL,P=0.003). CONCLUSION:Acu-TENS reduced rectal discomfort during barostat-induced rectal distension and concur-rently associated with a rise in beta-endorphin level. | Wing-Wa Leung Alice YM Jones Simon SM Ng Cherry YN Wong Janet FY Lee | 2013 | World Journal of Gastroenterology2013，19，3： | 0 |
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