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| 1 | Circulating extracellular RNAs,myocardial remodeling,and heart failure in patients with acute coronary syndrome显示文摘Background:Given high on-treatment mortality in heart failure(HF),identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues.Circulating extracellular RNAs(ex-RNAs)regulate important biological processes and are emerging as biomarkers of disease,but less is known about their role in the acute setting,particularly in the setting of HF.Methods:We examined the ex-RNA profiles of 296 acute coronary syndrome(ACS)survivors enrolled in the Transitions,Risks,and Actions in Coronary Events Center for Outcomes Research and Education Cohort.We measured 374 ex-RNAs selected a priori,based on previous findings from a large population study.We employed a two-step,mechanism-driven approach to identify ex-RNAs associated with echocardiographic phenotypes(left ventricular[LV]ejection fraction,LV mass,LV end-diastolic volume,left atrial[LA]dimension,and LA volume index)then tested relations of these ex-RNAs with prevalent HF(N=31,10.5%).We performed further bioinformatics analysis of microRNA(miRNAs)predicted targets’genes ontology categories and molecular pathways.Results:We identified 44 ex-RNAs associated with at least one echocardiographic phenotype associated with HF.Of these 44 exRNAs,miR-29-3p,miR-584-5p,and miR-1247-5p were also associated with prevalent HF.The three microRNAs were implicated in the regulation p53 and transforming growth factor-βsignaling pathways and predicted to be involved in cardiac fibrosis and cell death;miRNA predicted targets were enriched in gene ontology categories including several involving the extracellular matrix and cellular differentiation.Conclusions:Among ACS survivors,we observed that miR-29-3p,miR-584-5p,and miR-1247-5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF.Relevance for Patients:miR-29c-3p,miR-584-5p,and miR-1247-5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. | Khanh-Van Tran Kahraman Tanriverdi Gerard P.Aurigemma Darleen Lessard Mayank Sardana Matthew Parker Amir Shaikh Matthew Gottbrecht Zachary Milstone Selim Tanriverdi Olga Vitseva John F.Keaney Catarina I.Kiefe David D.McManus Jane E.Freedman | 2019 | Journal of Clinical & Translational Research2019，5，1： | 7 |
| 2 | Potato aphid Macrosiphum euphorbiae performance is determined by aphid genotype and not mycorrhizal fungi or water availability显示文摘 | Alison Jane Karley Matthew Emslie-Smith Alison Elizabeth Bennett | 2017 | Insect Science2017，24，6： | 4 |
| 3 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 4 | Early surgery in Crohn's disease a benefit in selected cases显示文摘AIM: To compare the outcomes of a cohort of Crohn's disease(CD) patients undergoing early surgery(ES) to those undergoing initial medical therapy(IMT).METHODS: We performed a review of a prospective database CD patients managed at a single tertiary institution. Inclusion criteria were all patients with ileal or ileocolonic CD between 1995-2014. Patients with incomplete data, isolated colonic or perianal CD were excluded. Primary endpoints included the need for, and time to subsequent surgery. Secondary endpoints included the number and duration of hospital admissions, and medical therapy. RESULTS: Forty-two patients underwent ES and 115 underwent IMT. The operative intervention rate at 5 years in the ES group was 14.2% vs IMT 31.3%(HR = 0.41, 95%CI: 0.23-0.72, P = 0.041). The ES group had fewer hospital admissions per patient [median 1 vs 3(P = 0.012)] and fewer patients required anti-TNF therapy than IMT(33.3% vs 57%, P = 0.003). A subgroup analysis of 62 IMT patients who had undergone surgery were compared to ES patients, and showed similar 5 year(from index surgery) re-operation rates 16.1% vs 14.3%. In this subset, a significant difference was still found in median number of hospital admissions favouring ES, 1 vs 2(P = 0.002).CONCLUSION: Our data supports other recent studies suggesting that patients with ileocolonic CD may have a more benign disease course if undergoing early surgical intervention, with fewer admissions to hospital and atrend to reduced overall operation rates. | Vinna An Lauren Cohen Matthew Lawrence Michelle Thomas Jane Andrews James Moore | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 5 | Impact and clinical usefulness of genetic data in the surgical management of colorectal cancer liver metastasis: a narrative review显示文摘Importance:In patients who undergo surgery for colorectal cancer liver metastases(CRLM),a number of somatic mutations have been associated with worse overall(OS)and recurrence-free survival(RFS).Although useful,an association with prognosis does not necessarily equate to an impact on surgical management.Objective:The aim of this review was to investigate whether the best-studied somatic mutations impact surgical management of CRLM by informing:(I)post-hepatectomy surveillance;(II)selection of surgical technique;(III)selection of optimal margin width;and(IV)selection of patients for surgery.Lastly,we discuss the refinement of genetic data from overall mutation status to specific variants,as well as lesser studied somatic mutations.Evidence Review:We conducted a computerized search using PubMed and Google Scholar for reports published so far,using mesh headings and keywords related to genetic data and CRLM.Findings:Genetic data may impact surgical management of CRLM in three ways.Firstly,KRAS mutations can predict lung recurrences.Secondly,KRAS mutations may help tailor margin width.Thirdly,KRAS mutations may help tailor surgical technique.Conclusions:Although genetic data may impact post-hepatectomy surveillance,selection of surgical technique and optimal margin width,their use to guide surgical selection remains elusive,as the data cannot support denying surgery to patients according to their somatic mutation profile. | Georgios Antonios Margonis Martin E.Kreis Jaeyun Jane Wang Carsten Kamphues Christopher L.Wolfgang Matthew J.Weiss | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 3 |
| 6 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 7 | Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.显示文摘 | Neil Woodford Matthew J. Ellington Juliana M. Coelho Jane F. Turton M. Elaina Ward Susan Brown Sebastian G.B. Amyes David M. Livermore | 2006 | International Journal of Antimicrobial Agents2006，，4： | 2 |
| 8 | Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Statement for Health Professionals From the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association显示文摘 | Jane W. Newburger Masato Takahashi Michael A. Gerber Michael H. Gewitz Lloyd Y. Tani Jane C. Burns Stanford T. Shulman Ann F. Bolger Patricia Ferrieri Robert S. Baltimore Walter R. Wilson Larry M. Baddour Matthew E. Levison Thomas J. Pallasch Donald A. Fa | 2004 | Circulation2004，，17： | 2 |
| 9 | Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease显示文摘 | Rajarshi Banerjee Michael Pavlides Elizabeth M. Tunnicliffe Stefan K. Piechnik Nikita Sarania Rachel Philips Jane D. Collier Jonathan C. Booth Jurgen E. Schneider Lai Mun Wang David W. Delaney Ken A. Fleming Matthew D. Robson Eleanor Barnes Stefan Neubaue | 2014 | Journal of Hepatology2014，，1： | 2 |
| 10 | The effectiveness of case-based learning in health professional education. A BEME systematic review: BEME Guide No. 23显示文摘 | Jill Elizabeth Thistlethwaite David Davies Samilia Ekeocha Jane M. Kidd Colin MacDougall Paul Matthews Judith Purkis Diane Clay | 2012 | Medical Teacher2012，，6： | 2 |
| 11 | Early Fluid Resuscitation Reduces Morbidity Among Patients With Acute Pancreatitis显示文摘 | Matthew G. Warndorf Jane T. Kurtzman Michael J. Bartel Mougnyan Cox Todd Mackenzie Sarah Robinson Paul R. Burchard Stuart R. Gordon Timothy B. Gardner | 2011 | Clinical Gastroenterology and Hepatology2011，，8： | 1 |
| 12 | Distribution of National Institutes of Health Stroke Scale in the Cincinnati/Northern Kentucky Stroke Study显示文摘 | Mathew Reeves Jane Khoury Kathleen Alwell Charles Moomaw Matthew Flaherty Daniel Woo Pooja Khatri Opeolu Adeoye Simona Ferioli Brett Kissela Dawn Kleindorfer | 2013 | Stroke2013，，11： | 1 |
| 13 | E-waste:an opportunity显示文摘 | Matthew J Realff Michele Raymond Jane C Ammons | 2004 | Materials Today2004，，1： | 1 |
| 14 | Teaching motivational interviewing to first - year medical students to improve counseling skills in health behavior change显示文摘 | Maria K Matthew MC Jane HC | 2004 | Mayo Clinic Proceedings2004，79，3： | 1 |
| 15 | Evidence for Microvascular Dysfunction in Hypertrophic Cardiomyopathy: New Insights From Multiparametric Magnetic Resonance Imaging显示文摘 | Steffen E. Petersen Michael Jerosch-Herold Lucy E. Hudsmith Matthew D. Robson Jane M. Francis Helen A. Doll Joseph B. Selvanayagam Stefan Neubauer Hugh Watkins | 2007 | Circulation2007，，18： | 1 |
| 16 | Risk Factors for Progression of Low-Grade Dysplasia in Patients With Barrett’s Esophagus显示文摘 | Sachin Wani Gary W. Falk Jane Post Lisa Yerian Matthew Hall Amy Wang Neil Gupta Srinivas Gaddam Mandeep Singh Vikas Singh Keng–Yu Chuang Vikram Boolchand Hemanth Gavini John Kuczynski Priti Sud Ajay Bansal Amit Rastogi Sharad C. Mathur Patrick Young Brook | 2011 | Gastroenterology2011，，4： | 1 |
| 17 | E-waste : an opportunity显示文摘 | Matthew JR Miehele R Jane CA | 2004 | Materials · today2004，7，： | 1 |
| 18 | A new approach to textile bleaching显示文摘 | Jane Matthews | 1999 | Journal of the Society of Dyers and Colourists1999，115，56： | 1 |
| 19 | Teaching motivational in- terviewing to first year medical students to improve counseling skills in health behavior change显示文摘 | Mariak Matthew MC Jane HC | 2004 | Mayo Clinic Proceedings2004，79，3： | 1 |
| 20 | A simple model for fitting mild, severe, and known cases during an epidemic with an application to the current SARSCoV- 2 pandemic显示文摘One of the major difficulties with modelling an ongoing epidemic is that often data is limited or incomplete,making it hard to estimate key epidemic parameters and outcomes(e.g.attack rate,peak time,reporting rate,reproduction number).In the current study,we present a model for data-fitting limited infection case data which provides estimates for important epidemiological parameters and outcomes.The model can also provide reasonable short-term(one month)projections.We apply the model to the current and ongoing COVID-19 outbreak in Canada both at the national and provincial/territorial level. | Matthew I.Betti Jane M.Heffernan | 2021 | Infectious Disease Modelling2021，6，1： | 1 |
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