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| 1 | Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism显示文摘Background:Parkinson’s disease characterized by oxidative stress and mitochondrial damage in the pars compacta of substantia nigra remains a challenge to manage with an added disadvantage of side effects of L-levo dopa,the standard drug used for therapy.Thus,an alternative approach of utilizing natural components would be beneficial in the management of the disease.The present study was aimed to investigate the potential role of asiaticoside(As),a trisaccaride triterpene against1–methyl 4–phenyl 1,2,3,6 tetrahydropyridine(MPTP)-induced neurotoxicity in experimental mice.Methods:Mice were divided into 4 groups:Group I received vehicle saline,group II was treated with 20 mg/kg of body weight of MPTP(2 doses with 2 h intervals),group III received MPTP along with 50 mg/kg body weight of As for the 21 consecutive days starting from the day of MPTP intoxication.Group IV received 50 mg/kg body weight of asiaticoside for the same period serving as drug control.Animals were sacrificed at the end of experimental period and the striatum and midbrain samples were analyzed for enzyme assays,transmission electron microscopic(TEM)analysis.Immunofluorescent assay was performed to study the expression of GFAP to detect astrocyte,which are activated due to neuronal damage.Imunohistochemical studies were carried out to quantify the expression of Bax and Bcl2,the molecular signatures that would provide clues of the extent of neurodegeneration.Results:The activities of enzymes were increased on As administration when compared with those of group II animals.Expressions of Bax and Bcl2 along with GFAP did show significant variations(p<0.05)on MPTP treatment when compared to control animals and the changes were found to be reversed significantly(p<0.05)after treatment with asiaticoside.TEM analysis also showed attenuated degenerative architecture on As administration.The mice which received As alone(drug control IV)did not show significant variation from that of the control mice.Conclusion:The observations suggest that asiaticoside may be efficacious in protecting neurons from the oxidative damage caused by the insult of MPTP. | Uvarajan Sampath Vanisree Arambakkam Janardhanam | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 2 | Determination of rhodium in water samples using cloud pointextraction coupled with flame atomic absorption spectrometry 显示文摘 | SUVARDHAN K SURESH K REKHA D SUBRAHMANYAM P KIRAN K JAYARAJ B RAMANAIAH S JANARDHANAM K CHIRANJEEVI P | 2007 | Microchim Acta2007，157，34： | 1 |
| 3 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid,rifampicin and pyrazinamide显示文摘 | Parthasarathy R Sarma GR Janardhanam B | 1986 | Tubercle1986，67，2： | 1 |
| 4 | Speciation determination of chromium(Ⅲ) and (Ⅵ) using preconcentration cloud point extraction with flame atomic absorption spectrometry (FAAS)显示文摘 | KIRAN K KUMAR K S PRASAD B SUVARDHAN K LEKKALA R B JANARDHANAM K | 2008 | J Hazard Mater2008，150，3： | 1 |
| 5 | A controlled study of the influence of segregation of tuberculous patients for one year on the attack rate of tuberculosis in a 5-year period of close family contacts in south India 显示文摘 | Kamat SR Dawson JJ Devadatta S Fox W Janardhanam B Radhakrishna S Ramakrishnan CV Somasundaram PR Stott H Velu S | 1966 | Bull World Health Organ1966，34，4： | 1 |
| 6 | Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization-an in vitro study using scanning electron microscope and DIAGNOdent显示文摘 | Jayarajan J Janardhanam P Jayakumar P | 2011 | Indian J Dent Res2011，22，1： | 1 |
| 7 | Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization-An in vitro study using scanning electron microscope and DIAGNOdent显示文摘 | Jayarajan J Janardhanam P Jayakumar P | 2011 | Indian J Dent Res2011，22，1： | 1 |
| 8 | Preconeentration and solid phase extraction method for the determination of Co,Cu,Ni, Zn and Cd in environmental and biological samples using activated carbon by FAAS显示文摘 | Kiran K Kumar K S Suvm'dhan K Janardhanam K | 2007 | Journal of Hazardous Material2007，147，12： | 1 |
| 9 | Hepatic toxicity in South Indian patients during treatment oftuberculosis with short course regimens containing isoniazid,ri- fampicin and pyrazinamide显示文摘 | PARTHASARATHY R SARMA GR JANARDHANAM B | 1986 | Tuberculosis1986，67，2： | 1 |
| 10 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide显示文摘 | Parthasarathy R Sarma GR Janardhanam B | 1986 | Tubercle1986，67，2： | 1 |
| 11 | Naringenin, a flavanone alters the tumorigenic features of C6 glioma cells显示文摘 | Devan Sabarinathan Arambakkam Janardhanam Vanisree | 2011 | Biomedicine & Preventive Nutrition2011，，1： | 1 |
| 12 | Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization-an in vitro study using scanning electron microscope and DIAGNOdent显示文摘 | Jayarajan J Janardhanam P Jayakumar P | 2011 | Indian J Dent Res2011，22，1： | 1 |
| 13 | Efficacy of CPP- ACP and CPP-ACPF on enamel remineralization-an in vitro study using scanning electron microscope and DIAGNOdent显示文摘 | Jayarajan J Janardhanam P Jayakumar P | 2011 | Indian J Dent Res2011，22，1： | 1 |
| 14 | Judd-Ofelt parameterization and radiative transitions analysis of Tm3+ doped alkali chloroborophosphate glasses显示文摘 | MOORTHY RAO T S JANARDHANAM J | 1999 | Optical Materials1999，12，： | 1 |
| 15 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid,rifampiein and pyrazinamide显示文摘 | Parthasarathy R Sarma G R Janardhanam B | 1986 | Tubercle1986，67，： | 1 |
| 16 | Development of a constitutive law for an atificial soil显示文摘 | Sture S Desai C S Janardhanam R | 1979 | Numerical Methods in Geotechnics1979，1，： | 1 |
| 17 | Process optimization for the treatment of pharmaceutical wastewater catalyzed by poly sulpha sponge显示文摘 | Sekar Karthikeyan Madhava Anil Kumar Pounsamy Maharaja Thamodaran Partheeban Janardhanam Sridevi Ganesan Sekaran | 2014 | Journal of the Taiwan Institute of Chemical Engineers2014，，： | 1 |
| 18 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short course regimens containing isoniazid,rifampicin and pyrazinamide显示文摘 | Parthasarathy R Sarma GR Janardhanam B | | 0，，02： | 1 |
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