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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 3 | Digital simulation of random process and its application 显示文摘 | Shinozuka M Jan C M | 1972 | Journal of Sound and Vibration1972，25，1： | 1 |
| 4 | Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia 显示文摘 | Chao MP Alizadeh AA Tang C Jan M Weissman-Tsukamoto R Zhao F | 2011 | Cancer Res2011，71，4： | 1 |
| 5 | Digital simulation of random processes and its applications显示文摘 | Shinozuka M Jan C M | 1972 | Journal of Sound and Vibration1972，25，1： | 1 |
| 6 | Energy Aware Routing for Low Energy AdHoc Sensor Networks 显示文摘 | Rahul C Shah Jan M Rabaey | 2002 | Proe IEEE Wireless Communications and Networking Con-ference ( WCNC) March2002，1，3： | 1 |
| 7 | Contribution of water content and bulk density to field soil penetration resistance as measured by a combined cone penetrometer-TDR probe显示文摘 | Vaz M P C Bassoi H L Hopmans W Jan | 2001 | Soil and Tillage Research2001，60，12： | 1 |
| 8 | Morphogenesis of HHV8 in primary human dermal microvascular endothelium and primary effusion显示文摘 | Jan M O Dolores M C | 2000 | Ultrastruct Pathol2000，24，： | 1 |
| 9 | Robust PID control design for per- manent magnet synchronous motor:a genetic approach 显示文摘 | JAN R M TSENG C S LIU RJ | 2008 | Electric Power Systems Research2008，78，7： | 1 |
| 10 | Digital Simulation of Random Processes and Its Applications 显示文摘 | Shinozuka M Jan C M | 1972 | Sound and Vibration1972，25，1： | 1 |
| 11 | Digital simulation of random processes and Its applications 显示文摘 | Shinozuka M Jan C M | 1972 | Journal of Sound and Vibration1972，25，1： | 1 |
| 12 | Optimism as a predictor of health-related qualityof life in psoriatics显示文摘 | Joanna M Jan C Alicja O | 2013 | Postep Derm A-lergol2013，，2： | 1 |
| 13 | Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘 | Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John | 1999 | Gastroenterology1999，，4： | 1 |
| 14 | Balance equations for molecular distillation显示文摘 | Miroslav M Juraj L Jan C | 1997 | Separation Science and Technology1997，32，18： | 1 |
| 15 | Digital simulation of random processes and its applications显示文摘 | Shinozuka M Jan C M | 1972 | J Sound and Vibration1972，25，1： | 1 |
| 16 | Digital Simulation of Ran-dom Processes and Its Applications 显示文摘 | Shinozuka M Jan C M | 1972 | Journal ofSound and Vibration1972，25，1： | 1 |
| 17 | Digital simulation of random processes and its applications显示文摘 | Shinozuka M Jan C M | 1972 | Journal of Sound and Vibration1972，25，1： | 1 |
| 18 | Digital simulation of random processes and its applications 显示文摘 | SHINOZUKA M JAN C M | 1972 | Journal of Sound and Vibration1972，25，1： | 1 |
| 19 | Application of artificial neural networks in typhoon surge forecasting显示文摘 | Tseng C M Jan C D Wang J S | 2007 | Ocean Engineering2007，34，1112： | 1 |
| 20 | Comparison of upper airway respiratory resistance measurements with the esophageal pressure/airflow relationship during sleep 显示文摘 | Morgenstem C Schwaibold M Randerath W Bolz A Jan e R | 2011 | ConfProc IEEE EngMedBiolSoc2011，，： | 1 |
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