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| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 2 | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding显示文摘 | Joseph L Kim Kurt A Morgenstern James P Griffith Maureen D Dwyer John A Thomson Mark A Murcko Chao Lin Paul R Caron | 1998 | Structure1998，，1： | 1 |
| 3 | From bronchiolitis guideline to practice: A critical care perspective显示文摘Acute viral bronchiolitis is a leading cause of admission to pediatric intensive care units, but research on the care of these critically ill infants has been limited. Pathology of viral bronchiolitis revealed respiratory obstruction due to intraluminal debris and edema of the airways and vasculature. This and clinical evidence suggest that airway clearance interventions such as hypertonic saline nebulizers and pulmonary toilet devices may be of benefit, particularly in situations of atelectasis associated with bronchiolitis. Research to distinguish an underlying asthma predisposition in wheezing infants with viral bronchiolitis may one day lead to guidance on when to trial bronchodilator therapy. Considering the paucity of critical care research in pediatric viral bronchiolitis, intensive care practitioners must substantially rely on individualization of therapies based on bedside clinical assessments. However, with the introduction of new diagnostic and respiratory technologies, our ability to support critically ill infants with acute viral bronchiolitis will continue to advance. | James A Lin Andranik Madikians | 2015 | World Journal of Critical Care Medicine2015，4，3： | 1 |
| 4 | Unit root tests in panel data: Asymptotic and finite - sample properties 显示文摘 | Levin A Lin C F James Chu C S | 2002 | Journal of Econometrics2002，108，1： | 1 |
| 5 | Characterization of Sol-gel-derived cobalt oxide xero- gels as electrochemical capacitors 显示文摘 | Lin Chuan Ritterand James A Popov Branko N | 1998 | J Electrochem Soc1998，145，12： | 1 |
| 6 | Unit Root Tests in Panel Data: Asymp-totic and Finite-sample Properties 显示文摘 | Levin A Lin C F James Chu C S | 2002 | JoumaI of econometrics2002，108，1： | 1 |
| 7 | Agency Costs and Ownership Structure显示文摘 | James SAng Rebel A Cole James Wuh Lin | 2000 | The Journal of Fi~ance2000，55，1： | 1 |
| 8 | Maize opaque5 encodes monogalaetosyldiacylglycerol synthase and specifically affects galactolipids necessary for amyloplast and chloroplast function 显示文摘 | MYERS A M JAMES M G LIN Q | 2011 | Plant Cell2011，23，6： | 1 |
| 9 | Unit root tests in panel data:asymptotic and finite-sample properties显示文摘 | Levin A Lin CF James CCS | | 0，，01： | 1 |
| 10 | Characteri-zation of sol-gel derived cobalt oxide xesgels as electrochemical capacitors显示文摘 | Chuan Lin James A Ritter Branko N Popov | 1998 | J Electrochem Soc1998，145，12： | 1 |
| 11 | Agency Cost and Ownership Stucture 显示文摘 | James S Rebel A Lin W | 2000 | Joumal of Finance2000，55，1： | 1 |
| 12 | Characterization of sol-gelderived cobalt oxide xerogels as electrochemical capacitors显示文摘 | LIN C JAMES R A BRANKO P N | 1998 | J Electrochem Soc1998，145，12： | 1 |
| 13 | Elucidating strategic network dynamics through computational modeling 显示文摘 | ZHIANG (JOHN) LIN JAMES A KITTS HARBIN YANG | 2008 | Computational & Mathematical Organization Theory2008，14，3： | 1 |
| 14 | Agency Cost and Owner- ship Stucture 显示文摘 | James S Rebel A Lin W | 2000 | Journal of Finance2000，55，1： | 1 |
| 15 | Elucidating strategic network dynamics through computational modeling显示文摘 | LIN Z L JAMES A K YANG H B | 2008 | Comput Math Organ Theory2008，，14： | 1 |
| 16 | Comparison of techniques for determing the fractal dimensions of clay minerals显示文摘 | KALUMBU MALCKANI JAMES A RICE JAR- SHYONG LIN | 1996 | Clays and Clay Minerals1996，44，5： | 1 |
| 17 | Clinical characteristics and outcomes associated with nasal intermittent mandatory ventilation in acute pediatric respiratory failure显示文摘AIM To characterize the clinical course and outcomes of nasal intermittent mandatory ventilation(NIMV) use in acute pediatric respiratory failure.METHODS We identified all patients treated with NIMV in the pediatric intensive care unit(PICU) or inpatient general pediatrics between January 2013 and December 2015 at two academic centers.Patients who utilized NIMV with other modes of noninvasive ventilation during the same admission were included.Data included demographics,vital signs on admission and prior to initiation of NIMV,pediatric risk of mortality Ⅲ(PRIsM-Ⅲ) scores,complications,respiratory support characteristics,PICU and hospital length of stays,duration of respiratory support,and complications.Patients who did not require escalation to mechanical ventilation were defined as NIMV responders;those who required escalation to mechanical ventilation(MV) were defined as NIMV nonresponders.NIMV responders were compared to NIMV non-responders.RESULTS Forty-two patients met study criteria.six(14%) failed treatment and required MV.The majority of the patients(74%) had a primary diagnosis of bronchiolitis.The median age of these 42 patients was 4 mo(range 0.5-28.1 mo,IQR 7,P = 0.69).No significant difference was measured in other baseline demographics and vitals on initiation of NIMV;these included age,temperature,respiratory rate,O2 saturation,heart rate,systolic blood pressure,diastolic blood pressure,and PRIsM-Ⅲ scores.The duration of NIMV was shorter in the NIMV nonresponder vs NIMV responder group(6.5 h vs 65 h,P < 0.0005).Otherwise,NIMV failure was not associated with significant differences in PICU length of stay(LOs),hospital LOs,or total duration of respiratory support.No patients had aspiration pneumonia,pneumothorax,or skin breakdown.CONCLUSION Most of our patients responded to NIMV.NIMV failure is not associated with differences in hospital LOs,PICU LOs,or duration of respiratory support. | Billy C Wang Theodore Pei Cheryl B Lin Rong Guo David Elashoff James A Lin Carol Pineda | 2018 | World Journal of Critical Care Medicine2018，7，4： | 1 |
| 18 | Unit root tests in panel data: asymptotic and finite -sam- ple properties 显示文摘 | Levin A Lin C F James Chu C S | 2002 | Journal of econometrics2002，108，1： | 1 |
| 19 | Effect of thermal treatment on the nanostructure of SiO2-Al2O3 xerogels显示文摘 | Lin Chuan James A R Michael D | 1997 | Journal of Non-Crystalline Solids1997，，215： | 1 |
| 20 | Elucidating Strategic Network Dynamics through Computational Modeling 显示文摘 | Lin Zhiang Kitts James A | 2008 | Computational & Mathematical Organization Theory2008，14，3： | 1 |
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