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| 1 | FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation显示文摘Tyrosine kinase inhibitors(TKIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other drugs.We investigated the combination of FLT3 TKIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia cells.The combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML samples.Venetoclax also re-sensitized FLT3 TKI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPK pathway inhibition.Gilteritinib treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to BCL-2.Venetoclax treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from BCL-2.Treatment with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased apoptosis.These findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TKI mainly through the dissociation of BIM and BCL-2 and also decreased BIM expression.This study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TKI therapy in FLT3/ITD AML treatment. | Ruiqi Zhu Li Li Bao Nguyen Jaesung Seo Min Wu Tessa Seale Mark Levis Amy Duffield Yu Hu Donald Small | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 2 | Current status and future advances for wind speed and power forecasting显示文摘 | Jaesung Jung Robert P. Broadwater | 2014 | Renewable and Sustainable Energy Reviews2014，，： | 2 |
| 3 | Efficacy of neutral electrolyzed water for sanitization of cutting boards used in the preparation of foods显示文摘 | Abigail Monnin Jaesung Lee Melvin A. Pascall | 2012 | Journal of Food Engineering2012，，4： | 2 |
| 4 | Efficacy of neutral electrolyzed water for sanitization of cutting boards used in the preparation of foods显示文摘 | Abigail M Jaesung L Melvin A P | 2012 | Journal of Food Engineering2012，10，4： | 1 |
| 5 | Ambipolar memory devices based on reduced graphene oxide and nanoparticles显示文摘 | Sung M Jaesung P Hyungwoo L | 2010 | Adv Mater2010，22，18： | 1 |
| 6 | A minimally invasive registration method using Surface Template-Assisted Marker Positioning (STAMP) for ima-ge-guided otologic surgery显示文摘 | Nozomu Matsumoto Jaesung Hong Makoto Hashizume | 2009 | Otolaryngology-Head and Neck Surgery2009，140，1： | 1 |
| 7 | Oncolysis of human gastric cancers by an E1B 55kDa-deleted YKL-1 adenovirus显示文摘 | Boyoung L Jene C Jaesung K | 2002 | Cancer Letters2002，185，2： | 1 |
| 8 | A Fast Quantitative Analysis and Performance Estimation Method of SoC Bus Architectures显示文摘Various multi-layered bus architectures are now being used in the So C industry. Reckless use of bus layers may result in low utilization of communication resource and waste silicon area. This paper introduces a quantitative analysis at the initial stage of So C design.The time complexity is examined and it is found that their scale is the order of n to the power of n, or combinatorial,and thus the problem is NP-complete. The paper proposes some heuristic methods through in-depth investigation and applies them to each step of the exploration to reduce the time complexity. The exploration processes and the proposed methods are implemented as a software program and several experiments are performed. From the results, the performance of SNP turns out to be significantly enhanced and achieves 25% enhancement in comparison with a defacto standard bus, AXI. For time complexity, the reduction ratio goes down to 3.7 × 10-6. | Jaesung Lee | 2014 | Chinese Journal of Electronics2014，23，4： | 1 |
| 9 | Ambipolar memory devices based on reduced graphene oxide and nanoparticles显示文摘 | Sung M Jaesung P Hyungwoo L etal | 2010 | Adv Mater2010，22，18： | 1 |
| 10 | Waterdispersible magnetite-reduced graphene oxide composites forarsenic removal显示文摘 | Vimlesh Chandra Jaesung Park Young Chun | 2010 | ACS Nano2010，4，7： | 1 |
| 11 | Ex- tracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary in?ammation induced by lipopolysaccharide in rats显示文摘 | Jang Beomsu Kim Jongchun Bae Jaesung | 2004 | Biotechnology Letters2004，26，： | 1 |
| 12 | ADSP Architecture for high-speed FFT in OFDM systems显示文摘 | LEE Jaesung MOH Sangan | 2002 | ETRI2002，，12： | 1 |
| 13 | Development of 10-kW preferential oxidation system for fuel cell vehicles显示文摘 | Seong Ho Lee Jaesung Han Kwan Young Lee | 2002 | J Power Sources2002，109，： | 1 |
| 14 | Convenient Synthesis of Phenyl Sulfides by a Borohydride Exchange Resin-Phenyl Disulfide System in Methanol显示文摘 | Nung M Y Jaesung C Jin H A | 1994 | J Org Chem1994，59，： | 1 |
| 15 | A Parallel Transmission Scheme for Allto-All Broadcast in Underwater Sensor Networks显示文摘 | Soonchul P Jaesung L I M | 2010 | IEICE transactions on communications2010，93，9： | 1 |
| 16 | The American Customer Satisfaction Index : Nature, Purpose, and Findings显示文摘 | Claes Fornell Michael D Johnson Eugene W Anderson Jaesung Cha Barbara Everitt Bryant | 1996 | Journal of Marketing1996，，10： | 1 |
| 17 | Determination of the PDE-5 inhibitors and their analogues by GC-MS and TMS derivat?ization显示文摘 | JAESUNG P HEESANG L YUJIN P | 2012 | Mass Spectrometry Letters2012，3，1： | 1 |
| 18 | Dye distribution in the dyeing of mixed denier polyester fabrics 显示文摘 | Jaesung Shin Martin Bide | 2000 | JSDC2000，116，10： | 1 |
| 19 | A Co- operative TDMA MAC Protocol Using Dynamic Slot Assignment Seheme显示文摘 | JongKwan Lee HongJun Noh Jaesung Lim | 2013 | IEEE ICOIN2013，5，13： | 1 |
| 20 | Medical navigation system for otologic surgery based on hybrid registration and virtual intraoperative computed tomography 显示文摘 | Jaesung H Matsumoto N Ouchida R | 2009 | Biomedical Engineering IEEE Transactions on2009，56，2： | 1 |
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