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| 1 | Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice显示文摘Background:Neuroinflammation and accumulation ofβ-amyloid(Aβ)play a significant role in the onset and progression of Alzheimer’s disease(AD).Our previous study demonstrated that signal transducer and activator of transcription-3(STAT3)plays a major role in neuroinflammation and amyloidogenesis.Methods:In the present study,we investigated the inhibitory effect of bee venom phospholipase A2(bvPLA2)on memory deficiency in Tg2576 mice,which demonstrate genetic characteristics of AD and the mechanism of its action at the cellular and animal level.For in vivo study,we examined the effect of bvPLA2 on improving memory by conducting several behavioral tests with the administration of bvPLA2(1 mg/kg)to Tg2576 mice.For in vitro study,we examined the effect of bvPLA2 on amyloidogenesis and neuroinflammation by treating bvPLA2 on LPSactivated BV2 cells.Results:We found that bvPLA2 alleviated memory impairment in Tg2576 mice,as demonstrated in the behavioral tests assessing memory.In the bvPLA2-treated group,Aβ,amyloid precursor protein(APP),and β-secretase 1(BACE1)levels and β-secretase activity were significantly decreased.Expression of pro-inflammatory cytokines and inflammation-related proteins decreased in the brain of bvPLA2-treated group,whereas anti-inflammatory cytokines increased.In addition,bvPLA2 reduced STAT3 phosphorylation in the brains of the bvPLA2-treated group.At the cellular level,bvPLA2 inhibits production of nitric oxide,pro-inflammatory cytokines,and inflammation-related proteins including p-STAT3.Additionally,bvPLA2 inhibits the production of Aβin cultured BV-2 cells.Results from the docking experiment,pull-down assay,and the luciferase assay show that bvPLA2 directly binds STAT3 and,thus,regulates gene expression levels.Moreover,when the STAT3 inhibitor and bvPLA2 were administered together,the anti-amyloidogenic and anti-inflammatory effects were further enhanced than when they were administered alone.Conclusion:These results suggest that bvPLA2 could restore memory by inhibiting the accumulation of Aβ and inflammatory responses via blockage of STAT3 activity. | Hyeon Joo Ham Sang-Bae Han Jaesuk Yun In Jun Yeo Young Wan Ham Se Hyun Kim Pil-Hoon Park Dong-Young Choi Jin Tae Hong | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 2 | Improvement on reactivity of cementitious waste mate- rials by mechano - chemical activation 显示文摘 | Jaesuk Ryou | 2003 | Materials Letter2003，58，： | 1 |
| 3 | Improvement on reactivity of cementitious waste materials by mechano-chemical activation显示文摘 | Jaesuk R | 2003 | Materials Letter2003，58，： | 1 |
| 4 | Porous silicon nanowires for lithium rechargeable batteries显示文摘 | Jung-Keun Yoo Jongsoon Kim Hojun Lee Jaesuk Choi Min-Jae Choi Dong Min Sim Yeon Sik Jung Kisuk Kang | 2013 | Nanotechnology2013，，42： | 1 |
| 5 | Improvement on reactivity of cementitious waste materi- als by mechano-chemical activation 显示文摘 | Jaesuk R | 2003 | Materials Letter2003，58，： | 1 |
| 6 | Corrosion Resistance of Functionally Graded Coatings on Plain Steel Rebars 显示文摘 | RYOU JAESUK Voigt THOMAS | 2005 | Advanced Concrete Technology2005，，2： | 1 |
| 7 | Corrosion resistance of functionally graded coatings on plain steel rebars 显示文摘 | Jaesuk R Thomas V Maria S | 2005 | Journal of Advanced Concrete Technology2005，3，1： | 1 |
| 8 | Desalination properties of a novel composite membrane with a lamination method显示文摘 | Kim YoungJea Jeong MyungHwan Lee JaeSuk | 2010 | Desalination and Water Treatment2010，15，19： | 1 |
| 9 | Improvement on reactivity of cementitious waste materials by mechano-chemical activation显示文摘 | | 2003 | Materials Letter2003，58，： | 1 |
| 10 | Improvement on reactivity of cementitious waste materialls by mechano-chemieal activation 显示文摘 | Jaesuk Ryou | 2003 | Materials Letter2003，58，： | 1 |
| 11 | Message from Editors显示文摘CURRENTLY,4th Industrial Revolution and Industry 4.0 have been the biggest move in the world from several years ago.Electrical vehicle and other electrical mobility system such as ship and aircraft,Smart factory and manufacturing have become the main issues of global industry market.Conventional power drive systems using internal combustion engine has been replaced by electric motor drive systems having high performance and ecofriendly features. | Taeuk JUNG Donghee Lee Dokwan Hong Seonhwan Hwang Jaesuk Lee | 2021 | CES Transactions on Electrical Machines and Systems2021，5，1： | 0 |
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