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| 1 | Gastric cancer surgery in cirrhotic patients: Result of gastrectomy with D2 lymph node dissection显示文摘AIM: To explore the feasibility of performing gastrectomy with D2 lymphadenectomy in gastric cancer patients with liver cirrhosis.METHODS: A total of 7 178 patients were admitted with a diagnosis of liver cirrhosis from January 1993 to December 2003. We reviewed the records of 142 patients who were diagnosed with liver cirrhosis and gastric adenocarcinoma during the same period. Gastrectomy with D2 lymph node dissection for carcinoma of the stomach was performed in 94 patients with histologically proven hepatic cirrhosis.RESULTS: All but 12 patients were classified as Child's class A. Only 35 patients (37.2%) were diagnosed with cirrhosis before operation. Seventy-three patients underwent a subtotal gastrectomy (77.7%) and 21 patients (22.3%)underwent a total gastrectomy, each with D2 or more lymph node dissection. Two patients (3.8%) who had prophylactic intra-operative drain placement, died of postoperative complications from hepatorenal failure with intractable ascites. Thirty-seven patients (39.4%) experienced postoperative complications. The extent of gastric resection did not influence the morbidity whereas serum aspartate aminotransferase level (P = 0.011) and transfusion did (P= 0.008). The most common postoperative complication was ascites (13.9%) followed by wound infection (10.6%).CONCLUSION: We concluded that the presence of compensated cirrhosis, i.e. Child class A, is not a contraindication against gastrectomy with D2 or more lymph node dissection, when curative resection for gastric cancer is possible. Hepatic reserve and meticulous hemostasis are the likely determinants of operative prognosis. | Jun Ho Lee Junuk Kim Jae Ho Cheong Woo Jin Hyung Seung Ho Choi Sung Hoon Noh | 2005 | World Journal of Gastroenterology2005，11，30： | 25 |
| 2 | 进展期胃癌的外科治疗显示文摘全球每年约有800000例胃癌新发病例,居于最常见的恶性肿瘤第4位,肿瘤相关死亡原因第2位。虽然胃癌发病率在西方国家持续下降,但是在亚洲、拉丁美洲和东欧依旧保持较高水平。据报道,全球大约42%的胃癌患者在中国。随着手术技术的改进、综合治疗方法的进步以及早期诊断能力的提高,最近几十年胃癌的总体生存率得到逐步提升。 | Kyung Min Kim 胡彦锋 Ji Yeong An Hyoung LI Kim Jae Ho Cheong Woo Jin Hyung Sung Hoon Noh | 2011 | 中华消化外科杂志2011，10，6： | 18 |
| 3 | Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway显示文摘 | Hyo Sang Go Ki Chan Kim Chang Soon Choi Se Jin Jeon Kyung Ja Kwon Seol-Heui Han Jongmin Lee Jae Hoon Cheong Jong Hoon Ryu Chong-Hyun Kim Kwang Ho Ko Chan Young Shin | 2012 | Neuropharmacology2012，，6： | 1 |
| 4 | Can we apply the same indication of endoscopic submucosal dissection for primary gastric cancer to remnant gastric cancer?显示文摘 | Yoon Young Choi In Gyu Kwon Sang Kil Lee Hyun Ki Kim Ji Yeong An Hyoung Il Kim Jae Ho Cheong Richard Thomas Mliwa Sung Kwan Shin Yong Chan Lee Woo Jin Hyung Sung Hoon Noh | 2014 | Gastric Cancer2014，，2： | 1 |
| 5 | Signet ring cell mixed histology may show more aggressive behavior than other histologies in early gastric cancer显示文摘 | Cheal Wung Huh Da Hyun Jung Jie‐Hyun Kim Yong Chan Lee Hyunki Kim Hoguen Kim Sun Och Yoon Young Hoon Youn Hyojin Park Sang In Lee Seung Ho Choi Jae‐Ho Cheong Sung Hoon Noh | 2012 | Oncol2012，，2： | 1 |
| 6 | A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma显示文摘 | Hyun Young Woo Si Hyun Bae Jun Yong Park Kwang Hyub Han Ho Jong Chun Byung Gil Choi Hyeon U. Im Jong Young Choi Seung Kew Yoon Jae Youn Cheong Sung Won Cho Byoung Kuk Jang Jae Seok Hwang Sang Gyune Kim Young Seok Kim Yeon Seok Seo Hyung Joon Yim Soon Ho U | 2010 | Cancer Chemotherapy and Pharmacology2010，，2： | 1 |
| 7 | Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma显示文摘 | Choong-Kyun Noh Soon Sun Kim Dong-Kyu Kim Hyun-Young Lee Hyo Jung Cho So Young Yoon Gil Ho Lee Sun A Hyun Yu Jeong Kim Ho Joong Kim Joo An Hwang Seun Joo Ahn Sung Jae Shin Kee Myung Lee Byung Moo Yoo Sung Won Cho Jae Youn Cheong | 2014 | Clinical Biochemistry2014，，： | 1 |
| 8 | Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer显示文摘 | Taeil Son Woo Jin Hyung Joong Ho Lee Yoo Min Kim Hyoung‐Il Kim Ji Yeong An Jae‐Ho Cheong Sung Hoon Noh | 2012 | Cancer2012，，19： | 1 |
| 9 | Survival benefit of metastasectomy for Krukenberg tumors from gastric cancer显示文摘 | Jae Ho Cheong Woo Jin Hyung Jian Chen Junuk Kim Seung Ho Choi Sung Hoon Noh | 2004 | Gynecologic Oncology2004，，： | 1 |
| 10 | Gastric cancer surgery without drains: A prospective randomized trial显示文摘 | Junuk Kim M.D. Junho Lee M.D. Woo Jin Hyung M.D. Jae Ho Cheong M.D. Jian Chen M.D. Seung Ho Choi M.D. Sung Hoon Noh M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 11 | Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta‐analysis显示文摘 | Yoon Young Choi Jung Min Bae Ji Yeong An In Gyu Kwon In Cho Hyun Beak Shin Tanaka Eiji Mohammad Aburahmah Hyung‐Il Kim Jae‐Ho Cheong Woo Jin Hyung Sung Hoon Noh | 2014 | J. Surg. Oncol2014，，2： | 1 |
| 12 | Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice显示文摘 | Dong Hyun Kim Do Yoon Kim Young Choong Kim Ji Wook Jung Seungjoo Lee Byung Hoon Yoon Jae Hoon Cheong Yeong Shik Kim Sam Sik Kang Kwang Ho Ko Jong Hoon Ryu | 2007 | Life Sciences2007，，： | 1 |
| 13 | Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer显示文摘 | Taeil Son Woo Jin Hyung Joong Ho Lee Yoo Min Kim Hyoung‐Il Kim Ji Yeong An Jae‐Ho Cheong Sung Hoon Noh | 2012 | Cancer2012，，19： | 1 |
| 14 | A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma显示文摘 | Hyun Young Woo Si Hyun Bae Jun Yong Park Kwang Hyub Han Ho Jong Chun Byung Gil Choi Hyeon U. Im Jong Young Choi Seung Kew Yoon Jae Youn Cheong Sung Won Cho Byoung Kuk Jang Jae Seok Hwang Sang Gyune Kim Young Seok Kim Yeon Seok Seo Hyung Joon Yim Soon Ho U | 2010 | Cancer Chemotherapy and Pharmacology2010，，2： | 1 |
| 15 | Impact of guideline adherence on the prognosis of Barcelona clinic liver cancer stage B hepatocellular carcinoma显示文摘BACKGROUND Patients with Barcelona clinic liver cancer(BCLC)stage B hepatocellular carcinoma(HCC)are considerably heterogeneous in terms of tumor burden,liver function,and performance status.To improve the poor survival outcomes of these patients,treatment approaches other than transarterial chemoembolization(TACE),which is recommended by HCC guidelines,have been adopted in realworld clinical practice.We hypothesize that this non-adherence to treatment guidelines,particularly with respect to the use of liver resection,improves survival in patients with stage B HCC.AIM To assess guideline adherence in South Korean patients with stage B HCC and study its impact on survival.METHODS A retrospective analysis was conducted using data from 2008 to 2016 obtained from the Korea Central Cancer Registry.Patients with stage B HCC were categorized into three treatment groups,guideline-adherent,upward,and downward,based on HCC guidelines recommended by the Asian Pacific Association for the Study of the Liver(APASL),the European Association for the Study of the Liver(EASL),and the American Association for the Study of Liver Diseases(AASLD).The primary outcome was HCC-related deaths;tumor recurrence served as the secondary outcome.Survival among the groups was compared using the Kaplan-Meier method and the log-rank test.Predictors of survival outcomes were identified using multivariable Cox regression analysis.RESULTS In South Korea, over the study period from 2008 to 2016, a notable trend was observed in adherence to HCCguidelines. Adherence to the EASL guidelines started relatively high, ranging from 77% to 80% between 2008 and2012, but it gradually declined to 58.8% to 71.6% from 2013 to 2016. Adherence to the AASLD guidelines began at71.7% to 75.9% from 2008 to 2010, and then it fluctuated between 49.2% and 73.8% from 2011 to 2016. In contrast,adherence to the APASL guidelines remained consistently high, staying within the range of 90.14% to 94.5%throughout the entire study period. Upward treatment, for example with liver resection, liver transplantation, orradiofrequency ablation, significantly improved the survival of patients with BCLC stage B HCC compared to thatof patients treated in adherence to the guidelines (for patients analyzed according to the 2000 EASL guidelines, the5-year survival rates were 63.4% vs 27.2%, P < 0.001), although results varied depending on the guidelines.Progression-free survival rates were also significantly improved upon the use of upward treatments in certaingroups. Patients receiving upward treatments were typically < 70 years old, had platelet counts > 105/μL, andserum albumin levels ≥ 3.5 g/dL.CONCLUSIONAdherence to guidelines significantly influences survival in South Korean stage B HCC patients. Curativetreatments outperform TACE, but liver resection should be selected with caution due to disease heterogeneity. | Ji Eun Han Hyo Jung Cho Jae Youn Cheong Sun Gyo Lim Min Jae Yang Choong-Kyun Noh Gil Ho Lee Soon Sun Kim | 2023 | World Journal of Gastroenterology2023，29，47： | 0 |
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