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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Identifi- cation and subtyping of Francisella by pyrosequencing and signature matching of 16S rDNA fragments 显示文摘 | Jacob D Wahab T Edvinsson B Peterzon A Boskani T Farhadi L Barduhn A Grunow R Sandstrom G | 2011 | Lett Appl Microbiol2011，53，6： | 1 |
| 3 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 4 | The role of ClC-3 in volume-activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition显示文摘 | Wang L Chen L Jacob T J | 2000 | J Physiol2000，524，： | 1 |
| 5 | Phylogeneticsof Panicoideae (Poaceae) based on chloroplast and nuclear DNAsequences 显示文摘 | Teerawatananon A Jacobs S W L Hodkinson T R | 2011 | Telopea2011，13，11： | 1 |
| 6 | Multiple elements in Typha angustifolia rhizosphere and plants : wetland versus dryland 显示文摘 | Kissoon L T T Jacob D L Otte M L | 2011 | Environmen- tal and Experimental Botany2011，72，2： | 1 |
| 7 | Eradication of invasive mucormycosis-effectiveness of the Echinocandin FK463 显示文摘 | JACOBS P WOOD L DU T | 2003 | Hematology2003，8，2： | 1 |
| 8 | Probabilistic environmental risk of hazardous materials 显示文摘 | Jacobs T L Vesilind P A | 1992 | Journal of Environmental Engineering1992，118，6： | 1 |
| 9 | Construction of one-and two-dimensional coordination polymers using ditopic imidazole ligands 显示文摘 | Dobrzanska L Lloyd G O Jacobs T | 2006 | J Mol Struct2006，796，123： | 1 |
| 10 | Randomised phase II study of cisplatin and 5-fluorouracil (5-FU) versus cisplatin alone in advanced squamous cell oesophageal cancer显示文摘 | H Bleiberg T Conroy B Paillot A.J Lacave G Blijham J.H Jacob L Bedenne M Namer P De Besi F Gay L Collette T Sahmoud | 1997 | European Journal of Cancer1997，，8： | 1 |
| 11 | Type IV secretion system is not involved in infection process in citrus 显示文摘 | Jacob T R Laia M L Moreira L M | 2014 | International Journal of Microbiology2014，，： | 1 |
| 12 | Carcinogen exposure during short-term switching from regular to ' light' cigarettes 显示文摘 | BENOWITZ N L JACOB P 3RD BERNERT J T | 2005 | Cancer Epidemiol Biomarkers Prey2005，14，6： | 1 |
| 13 | Roles of volumeactivatedCl- currents and regulatory volume decrease in thecell cycle and proliferation in nasopharyngeal carcinoma cells显示文摘 | Chen L X Zhu L Y Jacob T J | 2007 | Cell Prolif2007，40，2： | 1 |
| 14 | Both carboxy- and amino-ter- minal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model显示文摘 | Bran& T A Jacobs B L | 2001 | J Virol2001，75，： | 1 |
| 15 | Probabilistic Envionmental Risk of Hazardous Matcrials显示文摘 | Jacobs T L Vesilind P A | 1992 | Journal of Envirormlental Engineering1992，118，6： | 1 |
| 16 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 17 | Effect of MMSE channel estimation on BER performance of orthogonal spaced-time block codes in rayleigh fading channels显示文摘 | JACOBS L T MOENECLAEY M | 2009 | IEEE Trans on Communications2009，57，5： | 1 |
| 18 | Carbohydrates, dietary fiber, and incident type 2 diabetes in older women 显示文摘 | Meyer K A Kushi L H Jacobs D R J Slavin J Sellers T A Folsom A R | 2000 | The American Journal of Clinical Nutrition2000，71，4： | 1 |
| 19 | Bladder cancer in 2010:how far have we come显示文摘 | Jacobs B L Lee C T Montie J g | 2010 | CA Cancer J Clin2010，60，： | 1 |
| 20 | The contribution of PDA in theneonate with severe RDS 显示文摘 | Jacob J Gluck L DiSessa T | 1980 | J Pediatr1980，96，1： | 1 |
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